DIAMET. Diabetes and metabolic associated diseases research group

NUTRICIÓ I METABOLISME
OBJECTIUS

El grup de recerca en Diabetis i Malalties Metabòliques Associades (DIAMET) és un grup de recerca multidisciplinari i dinàmic centrat en l’estudi dels trastorns metabòlics associats a la morbiditat de la diabetis mellitus i l’obesitat. El grup de recerca està liderat per la doctora Sonia Fernandez-Veledo i el doctor Joan Vendrell i està integrat per investigadors clínics i bàsics, tècnics i personal de suport administratiu.

RESPONSABLES
  • Sonia Fernández-Veledo

  • Joan Josep Vendrell Ortega

  • Presentació
  • Línies
  • Membres del grup
  • Projectes
  • Transferència
  • Publicacions
  • RECLUTAMENT
  • Contacte

El grup pertany a l’Institut d’Investigació Pere Virgili (IISPV) i a l’Hospital Universitari de Tarragona Joan XXIII (HJ23) i està integrat en una xarxa nacional d’estudi de la diabetis CIBERdem, iniciada el 2008 per l’Institut de Salut Carlos III. Així mateix, el grup és reconegut des del 2009 com a grup consolidat per l’Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya – Universitat Rovira i Virgili.

DIAMET compta amb una àmplia experiència en la formació d’estudiants de grau, estudiants de postgrau i formació post doctoral, tant en ciències clíniques com bàsiques. El grup integra investigadors de diferents programes de prestigi competitius com ara Miguel Servet i Ramón i Cajal, ajuts post doctorals juniors (Sara Borrell i Juan de la Cierva) i contractes de formació especialitzada en salut de Río Hortega. A més, el grup ha establert programes de formació de beques en laboratoris estrangers de prestigiosos grups de recerca a Europa i EUA.

  • El paper de les cèl·lules mare derivades del teixit adipós (ASC) en la plasticitat del teixit adipós.
  • Teixit adipós com a nexe que uneix el metabolisme i la immunitat.
  • Inflamació i signatura microbiana del teixit adipós.
  • Trastorns metabòlics en la diabetis gestacional: implicacions per al metabolisme de la placenta i el maneig de nutrients.
  • Buscar nous enllaços moleculars entre l’obesitat i el càncer.

  • Title: Metabolitos como nuevos sensores energeticos. Efectos beneficiosos sobre la salud metabólica en la obesidad, comparando restricción calórica diaria vs ayuno intermitente. Estudio Randomiado-Cruzado. PI20/00338

    Funding entity: Instituto de Salud Carlos III.

    Duration: 2020-2023

    Principal Investigator: Joan Vendrell Ortega, MD, Phd.

  • Title: Succinate/SUCNR1 axis: a novel target for anti-obesity therapies (METASUCC).

    Funding entity: Obra Social Fundació La Caixa (Proyectos Investigación en Salud 2020).

    Duration: 2020 – 2023

    Principal Investigator: Sonia Fernández-Veledo, Phd

  • Title: RTI2018-093919. Succinate as a new extracellular signalling metabolite govern in glucose homeostasis: SUCNR1, a molecular drug target in obesity and related diseases (SUC-HOM)

    Funding entity: Ministerio de Economía y Competitividad.

    Duration: 2019 – 2021

    Principal Investigator: Sonia Fernández-Veledo, Phd.

  • Title: Foo4Health

    Funding entity: EIT Health and EIT Food

    Duration: 2019

    Principal Investigator: Joan Vendrell Ortega, MD, Phd.

  • Title: Papel de la vía del succinato en la inflamación de los injertos renales procedentes de donantes cadáver.

    Funding entity: MXVI Convocatoria para la adjudicación de Ayudas a Proyectos de Investigación en salud 2019 de la Fundación Mutua Madrileña.

    Duration: 2019 – 2021

    Principal Investigator: Encarnación Díaz, MD, Phd (Fundació Puigvert).

  • Title: Eje Succinato/SUCNR1 en la diabetes gestacional: implicación de la inflamación en su function placentaria y su repercussion en el feto (PI18/00516).

    Funding entity: Instituto de Salud Carlos III.

    Duration: 2019 – 2021

    Principal Investigator: Ana Megia, MD, PhD

  • Title: An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s disease patients with different clinical activity.

    Funding entity: European Crohn´s and Colitis Foundation.

    Duration: 2019 – 2020

    Principal Investigator: Carolina Serena, PhD.

  • Title: El tejido adiposo perilesional (creeping fat) como elemento inmunomodulador de la disbiosis  intestinal en la enfermedad de Crohn (PI18/00037)

    Funding entity: Instituto de Salud Carlos III.

    Duration: 2019 – 2021

    Principal Investigator: Carolina Serena, PhD.

  • Title: Microbiota tumor metabolic regulation as prognostic factors in HNSCC. (LABAE18025AVIL)

    Funding entity: Asociación Española Contra el Cáncer (AEC).

    Duration: 2019-2022

    Principal Investigator: Francesc Xavier Avilés, MD, PhD.

    Collaboration. co-IP: Sonia Fernández-Veledo, PhD.

  • Title: Variabilidad funcional de las células madre mesenquimales del tejido adiposo (ASCs) tras la pérdida de peso. Relación con metafactores vinculados a la microbiota intestinal (PI17/01503)

    Funding entity: Instituto de Salud Carlos III

    Duration: 2018 – 2020

    Principal Investigator: Joan Vendrell Ortega, MD, PhD

    Coordinated project. Coordinator: Joan Vendrell Ortega, MD, PhD.

  • Title: Analyses of the global kinase activities in adipose tissue to find molecular differences resulting from insulin resistance across different clinical phenotypes from lean to obese and type 2 diabetic patients. Discovery of new targets for therapy (86/C/2016).

    Funding entity: Fundació La Marató TV3.

    Duration: 2017 – 2019

    Principal Investigator: Joan Vendrell Ortega, MD, PhD.

    Coordinated project. Coordinator: Joan Vendrell Ortega, MD, PhD.

  • Title: Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: Identification of new regulators amenable for the development of innovative therapies (225/C/2016).

    Funding entity: Fundació La Marató TV3.

    Duration: 2017 – 2019

    Principal Investigator: Sonia Fernández Veledo, PhD.

    Coordinated project. Coordinator: Antonio Zorzano, PhD.

  • Title: New probiotic strategies for obesity-related disorders and development of the companion diagnostic kit. IU68-018623. 2019 INNOV 00008

    Funding entity: AGAUR AJUT INNOVADORS

    Duration: 2020– 2022

    Principal Investigator: Sonia Fernández-Veledo

  • Title: Nuevas Estrategias probióticas para la obesidad y desarrollo de su kit diagnostico. IU68-017106

    Funding entity: AGAUR AJUT PRODUCTE

    Duration: 2020 – 2021

    Principal Investigator: Sonia Fernández-Veledo

  • Title: Valorització d’una nova estratègia probiòtica pel tractament de la obesitat i el desenvolupament d’un kit auto usuari pel maneig diagnòstic/terapèutic. R2B2019/11

    Funding entity: URV. Research bussiness

    Duration: 2020

    Principal Investigator: Sonia Fernández-Veledo

  • Title: Validació i estudi de valorització d’un nou mètode de selecció de cèl·lules mare mesenquimals (MSCs). R2B2018/07

    Funding entity: URV Research bussiness

    Duration: 2019

    Principal Investigator: Sonia Fernández-Veledo

  • Title: A new probiotic strategy to improve metabolic and inflammatory profile in obese patients. SUCCIPRO.

    Funding entity: Caixaimpulse. Fundación la Caixa.

    Duration: 2019 – 2021

    Principal Investigator: Isabel Huber

  • Title: DTS19/00040. New probiotic strategies for obesity-related disturbances and its companion diagnostic.

    Funding entity:Instituto de salut Carlos III.

    Duration: 2019 – 2021

    Principal Investigator: Sonia Fernández Veledo

  • Title: Targeted interventions directed at reducing the levels of circulating succinate in a subject, and kits and method for determining effectiveness of said interventions.

    Reference number: PCT/EP2019/051157.

    Inventors: Sonia Fernández-Veledo; Joan Vendrell; Carolina Serena; Victoria Ceperuelo-Mallafré; Enrique Calvo.

    Registration date: 2019

  • Title: Succinate as a biomarker for selecting a bariatric surgical procedure and for predicting type 2 diabetes mission after bariatric surgery.

    Reference number: EP1938254. 

    Inventors:Sonia Fernández-Veledo; Joan Vendrell; Victoria Ceperuelo-Mallafré; Nuria Vilarrasa; Gemma Llauradó.

    Registration date: 2019

  • Title: Targeted interventions directed at reducing the levels of circulating succinate ina a subject, and kits and method for determining effectiveness of said interventions.

    Reference number: EP18382020.8.

    Inventors:Sonia Fernández-Veledo; Joan Vendrell; Carolina serena; Victoria Ceperuelo-Mallafré

    Registration date: 2018

  • Title: Methods for improving the cell therapy efficacy with mesenchymal stem cell populations España.

    Reference number: EP17382615.7.

    Inventors: Sonia Fernández-Veledo; Joan Vendrell; Carolina Serena; Antonio Zorzano.

    Registration Date: 2017

  • Title: Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders.

    Inventors: Mellitus SL (Joan Vendrell Ortega).

    Registratiion Date: 2007

  • Title: Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease.

    Inventors: Mellitus SL (Joan Vendrell Ortega).

    Registration Date: 2005

  • Title: Use of soluble CD14 for treatment of diseases.

    Inventors: Mellitus SL (Joan Vendrell Ortega).

    Registration Date: 2004

    Año

    Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring

    Algaba-Chueca F, Maymó-Masip E, Ejarque M, Ballesteros M, Llauradó G, López C, Guarque A, Serena C, Martínez-Guasch L, Gutiérrez C, Bosch R, Vendrell J, Megía A, Fernández-Veledo S. Stem Cells Transl Med. 2020 Mar;9(3):351-363. doi: 10.1002/sctm.19-0242. Epub 2019 Dec 27. PMID: 31880859 Free PMC article.

    Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study

    Llauradó G, Amigó N, Cano A, Ballesta S, Albert L, Mazarico I, Fernández-Veledo S, Pedro-Botet J, Vendrell J, González-Clemente JM. J Clin Med. 2019 Nov 5;8(11):1875. doi: 10.3390/jcm8111875. PMID: 31694246 Free PMC article.

    Changes in Bone Mineral Density in Patients with Type 2 Diabetes After Different Bariatric Surgery Procedures and the Role of Gastrointestinal Hormones

    Guerrero-Pérez F, Casajoana A, Gómez-Vaquero C, Virgili N, López-Urdiales R, Hernández-Montoliu L, Pujol-Gebelli J, Osorio J, Alves C, Perez-Maraver M, Pellitero S, Vidal-Alabró A, Fernández-Veledo S, Vendrell J, Vilarrasa N. Obes Surg. 2020 Jan;30(1):180-188. doi: 10.1007/s11695-019-04127-5. PMID: 31420830 Clinical Trial.

    Adipose stem cells from patients with Crohn's disease show a distinctive DNA methylation pattern

    Serena C, Millan M, Ejarque M, Saera-Vila A, Maymó-Masip E, Núñez-Roa C, Monfort-Ferré D, Terrón-Puig M, Bautista M, Menacho M, Martí M, Espin E, Vendrell J, Fernández-Veledo S. Clin Epigenetics. 2020 Apr 6;12(1):53. doi: 10.1186/s13148-020-00843-3. PMID: 32252817 Free PMC article.

    Microbial Signature in Adipose Tissue of Crohn's Disease Patients

    Serena C, Queipo-Ortuño M, Millan M, Sanchez-Alcoholado L, Caro A, Espina B, Menacho M, Bautista M, Monfort-Ferré D, Terrón-Puig M, Núñez-Roa C, Maymó-Masip E, Rodriguez MM, Tinahones FJ, Espin E, Martí M, Fernández-Veledo S, Vendrell J. J Clin Med. 2020 Jul 31;9(8):2448. doi: 10.3390/jcm9082448. PMID: 32751800 Free PMC article.

    Adipose tissue is a key organ for the beneficial effects of GLP-2 on glucose metabolism

    Ejarque M, Sabadell-Basallote J, Beiroa D, Calvo E, Keiran N, Nuñez-Roa C, Del Mar Rodríguez M, Sabench F, Del Castillo D, Jimenez V, Bosch F, Nogueiras R, Vendrell J, Fernández-Veledo S. Br J Pharmacol. 2020 Sep 28. doi: 10.1111/bph.15278. Online ahead of print. PMID: 32986861

    Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?

    López-Cano C, Gutiérrez-Carrasquilla L, Barbé F, Sánchez E, Hernández M, Martí R, Ceperuelo-Mallafre V, Dalmases M, Fernández-Veledo S, Vendrell J, Hernández C, Simó R, Lecube A. J Clin Med. 2020 Aug 13;9(8):2632. doi: 10.3390/jcm9082632. PMID: 32823749 Free PMC article.

     

    Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery

    Astiarraga B, Martínez L, Ceperuelo-Mallafré V, Llauradó G, Terrón-Puig M, Rodríguez MM, Casajoana A, Pellitero S, Megía A, Vilarrasa N, Vendrell J, Fernández-Veledo S. Diabetes Care. 2020 Oct;43(10):2581-2587. doi: 10.2337/dc20-0460. Epub 2020 Jul 31. PMID: 32737141 Free PMC article

    Utility of Insulin Resistance in Estimating Cardiovascular Risk in Subjects with Type 1 Diabetes According to the Scores of the Steno Type 1 Risk Engine

    Cano A, Llauradó G, Albert L, Mazarico I, Astiarraga B, González-Sastre M, Martínez L, Fernández-Veledo S, Simó R, Vendrell J, González-Clemente JM. J Clin Med. 2020 Jul 11;9(7):2192. doi: 10.3390/jcm9072192. PMID: 32664522 Free PMC article.

    Long-Term Effects in Bone Mineral Density after Different Bariatric Procedures in Patients with Type 2 Diabetes: Outcomes of a Randomized Clinical Trial

    Guerrero-Pérez F, Casajoana A, Gómez-Vaquero C, Virgili N, López-Urdiales R, Hernández-Montoliu L, Pujol-Gebelli J, Osorio J, Prats A, Vidal-Alabró A, Pérez-Maraver M, Fernández-Veledo S, Vendrell J, Vilarrasa N. J Clin Med. 2020 Jun 11;9(6):1830. doi: 10.3390/jcm9061830. PMID: 32545353 Free PMC article.

    Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study.

    Rojo-Martínez G, Valdés S, Soriguer F, Vendrell J, Urrutia I, Pérez V, Ortega E, Ocón P, Montanya E, Menéndez E, Lago-Sampedro A, González-Frutos T, Gomis R, Goday A, García-Serrano S, García-Escobar E, Galán-García JL, Castell C, Badía-Guillén R, Aguilera-Venegas G, Girbés J, Gaztambide S, Franch-Nadal J, Delgado E, Chaves FJ, Castaño L, Calle-Pascual A. Sci Rep. 2020 Feb 17;10(1):2765. doi: 10.1038/s41598-020-59643-7. PMID: 32066839

    Incidence and regression of metabolic syndrome in a representative sample of the Spanish population: results of the cohort di@bet.es study.

    Cuesta M, Fuentes M, Rubio M, Bordiu E, Barabash A, Garcia de la Torre N, Rojo-Martinez G, Valdes S, Soriguer F, Vendrell JJ, Urrutia IM, Ortega E, Montanya E, Menendez E, Lago-Sampedro A, Gomis R, Goday A, Castell C, Badia-Guillen R, Girbés J, Gaztambide S, Franch-Nadal J, Delgado Álvarez E, Chaves FJ, Castano L, Calle-Pascual AL. BMJ Open Diabetes Res Care. 2020 Oct;8(1):e001715. doi: 10.1136/bmjdrc-2020-001715. PMID: 33051280

    Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring

    Algaba-Chueca F., Maymó-Masip E. et Al.Stem Cells Transl. Med. 2019 Dec 27. doi: 10.1002/sctm.19-0242. [Epub ahead of print] PMID:31880859

    Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study

    Llauradó G. et Al.  J. Clin. Med. 2019 Nov 5;8(11). pii: E1875. doi: 10.3390/jcm8111875. PMID:31694246

    Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?

    Fernández-Veledo S, Vendrell J. Rev Endocr Metab Disord. 2019 Dec;20(4):439-447. doi: 10.1007/s11154-019-09513-z. Review. PMID:31654259

    Arterial stiffness is highly correlated with the scores obtained from the Steno Type 1 Risk Engine in subjects with T1DM

    Llauradó G, Cano A, et Al.  PLoS One. 2019 Sep 4;14(9):e0220206. doi: 10.1371/journal.pone.0220206. eCollection 2019. PMID:31483791

    Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery

    Ceperuelo-Mallafré V and Llauradó G et al.Diabetes Care. 2019 Aug 2. pii: dc190114. doi: 10.2337/dc19-0114. [Epub ahead of print] PMID:31375523

    Changes in Bone Mineral Density in Patients with Type 2 Diabetes After Different Bariatric Surgery Procedures and the Role of Gastrointestinal Hormones

    Guerrero-Pérez F et al Obes Surg. 2019 Aug 16. doi: 10.1007/s11695-019-04127-5. [Epub ahead of print] PMID:31420830

    Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

    Hernández-Alvarez MI et al. Cell. 2019 May 2;177(4):881-895.e17. doi: 10.1016/j.cell.2019.04.010. PMID: 31051106

    SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

    Keiran N and Ceperuelo-Mallafré V et al. Nat Immunol. 2019 Apr 8. doi: 10.1038/s41590-019-0372-7. [Epub ahead of print]

    Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes

    Ejarque M et al. Sci Rep. 2019 Apr 18;9(1):6274. doi: 10.1038/s41598-019-42770-1.PMID: 31000783

    Accuracy of new recommendations for adrenal incidentalomas in the evaluation of excessive cortisol secretion and follow-up

    Ruiz A, et al. Eur J Clin Invest. 2019 Feb;49(2):e13048. doi: 10.1111/eci.13048. Epub 2018 Dec 7. PMID: 30412278

Membres De L’equip

  • Responsable de grup

    • Sonia Fernández-Veledo
    • Joan Josep Vendrell Ortega
  • Assistencial

    • Laia Martínez Guasch
    • Esther Solano Fraile
    • Theodora Michalopoulou Alevras
    • Mónica Millán
    • Mónica Ballesteros
    • Carme Martí Mezcua
    • Albert Guarque Rus
    • Albert Pardo Balteiro
    • Cristina Díaz Perdigones
    • Adrià Rodríguez Castellano
  • Investigador/a sènior

    • Míriam Ejarque Carbó
    • Carolina Serena Perelló
    • Victoria Ceperuelo Mallafré
    • Ana Megía Colet
  • Investigador/a post-doctoral

    • Ana Paula da Silva Madeira
    • Enrique Calvo Manso
    • Brenno Domínguez Porfirio
    • Lídia Cedó Giné
  • Technology Transfer and Innovation Manager

    • Isabel Huber Ruano
  • Tècnic/a

    • Diandra Monforte
    • Catalina Núñez Roa
    • M. Mar Rodríguez Peña
    • Elsa Maymó Masip
  • Doctorant/da

    • Sergyi Klid
    • Joan Sabadell Basallote
    • Ester Benaiges Moragrega
    • Margarida Terrón Puig
    • Noelia Keiran Fernández