The Diabetes and Associated Metabolic Diseases Research Group (DIAMET) is a multidisciplinary and dynamic research group focused on the study of metabolic disorders associated with diabetes mellitus morbidity and obesity. The research group is led by Dr. Sonia Fernandez-Veledo and Dr. Joan Vendrell and is comprised of clinical and basic researchers, technicians and administrative support staff.
Dra. Sonia Fernández-Veledo
Dr. Joan Josep Vendrell Ortega
The group belongs to the Pere Virgili Research Institute (IISPV) and the Joan XXIII University Hospital of Tarragona (HJ23) and is part of a national diabetes study network CIBERdem, started in 2008 by the Institut de Hello Carlos III. The group has also been recognized since 2009 as a group consolidated by the Agency for the Management of University and Research Grants (AGAUR) of the Generalitat de Catalunya – Universitat Rovira i Virgili.
DIAMET has extensive experience in the training of undergraduate, postgraduate and postdoctoral students in both clinical and basic sciences. The group integrates researchers from different prestigious competitive programs such as Miguel Servet and Ramón i Cajal, junior postdoctoral grants (Sara Borrell and Juan de la Cierva) and specialized training contracts in Río Hortega health. In addition, the group has established scholarship training programs in foreign laboratories of prestigious research groups in Europe and the USA.
Title: Metabolitos como nuevos sensores energeticos. Efectos beneficiosos sobre la salud metabólica en la obesidad, comparando restricción calórica diaria vs ayuno intermitente. Estudio Randomiado-Cruzado. PI20/00338
Funding entity: Instituto de Salud Carlos III.
Duration: 2020-2023
Principal Investigator: Joan Vendrell Ortega, MD, Phd.
Title: Succinate/SUCNR1 axis: a novel target for anti-obesity therapies (METASUCC).
Funding entity: Obra Social Fundació La Caixa (Proyectos Investigación en Salud 2020).
Duration: 2020 – 2023
Principal Investigator: Sonia Fernández-Veledo, Phd
Title: RTI2018-093919. Succinate as a new extracellular signalling metabolite govern in glucose homeostasis: SUCNR1, a molecular drug target in obesity and related diseases (SUC-HOM)
Funding entity: Ministerio de Economía y Competitividad.
Duration: 2019 – 2021
Principal Investigator: Sonia Fernández-Veledo, Phd.
Title: Foo4Health
Funding entity: EIT Health and EIT Food
Duration: 2019
Principal Investigator: Joan Vendrell Ortega, MD, Phd.
Title: Papel de la vía del succinato en la inflamación de los injertos renales procedentes de donantes cadáver.
Funding entity: MXVI Convocatoria para la adjudicación de Ayudas a Proyectos de Investigación en salud 2019 de la Fundación Mutua Madrileña.
Duration: 2019 – 2021
Principal Investigator: Encarnación Díaz, MD, Phd (Fundació Puigvert).
Title: Eje Succinato/SUCNR1 en la diabetes gestacional: implicación de la inflamación en su function placentaria y su repercussion en el feto (PI18/00516).
Funding entity: Instituto de Salud Carlos III.
Duration: 2019 – 2021
Principal Investigator: Ana Megia, MD, PhD
Title: An integrative analysis of DNA methylation and RNA-Seq data in human adipose-stem cells of Crohn’s disease patients with different clinical activity.
Funding entity: European Crohn´s and Colitis Foundation.
Duration: 2019 – 2020
Principal Investigator: Carolina Serena, PhD.
Title: El tejido adiposo perilesional (creeping fat) como elemento inmunomodulador de la disbiosis intestinal en la enfermedad de Crohn (PI18/00037)
Funding entity: Instituto de Salud Carlos III.
Duration: 2019 – 2021
Principal Investigator: Carolina Serena, PhD.
Title: Microbiota tumor metabolic regulation as prognostic factors in HNSCC. (LABAE18025AVIL)
Funding entity: Asociación Española Contra el Cáncer (AEC).
Duration: 2019-2022
Principal Investigator: Francesc Xavier Avilés, MD, PhD.
Collaboration. co-IP: Sonia Fernández-Veledo, PhD.
Title: Variabilidad funcional de las células madre mesenquimales del tejido adiposo (ASCs) tras la pérdida de peso. Relación con metafactores vinculados a la microbiota intestinal (PI17/01503)
Funding entity: Instituto de Salud Carlos III
Duration: 2018 – 2020
Principal Investigator: Joan Vendrell Ortega, MD, PhD
Coordinated project. Coordinator: Joan Vendrell Ortega, MD, PhD.
Title: Analyses of the global kinase activities in adipose tissue to find molecular differences resulting from insulin resistance across different clinical phenotypes from lean to obese and type 2 diabetic patients. Discovery of new targets for therapy (86/C/2016).
Funding entity: Fundació La Marató TV3.
Duration: 2017 – 2019
Principal Investigator: Joan Vendrell Ortega, MD, PhD.
Coordinated project. Coordinator: Joan Vendrell Ortega, MD, PhD.
Title: Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: Identification of new regulators amenable for the development of innovative therapies (225/C/2016).
Funding entity: Fundació La Marató TV3.
Duration: 2017 – 2019
Principal Investigator: Sonia Fernández Veledo, PhD.
Coordinated project. Coordinator: Antonio Zorzano, PhD.
Title: New probiotic strategies for obesity-related disorders and development of the companion diagnostic kit. IU68-018623. 2019 INNOV 00008
Funding entity: AGAUR AJUT INNOVADORS
Duration: 2020– 2022
Principal Investigator: Sonia Fernández-Veledo
Title: Nuevas Estrategias probióticas para la obesidad y desarrollo de su kit diagnostico. IU68-017106
Funding entity: AGAUR AJUT PRODUCTE
Duration: 2020 – 2021
Principal Investigator: Sonia Fernández-Veledo
Title: Valorització d’una nova estratègia probiòtica pel tractament de la obesitat i el desenvolupament d’un kit auto usuari pel maneig diagnòstic/terapèutic. R2B2019/11
Funding entity: URV. Research bussiness
Duration: 2020
Principal Investigator: Sonia Fernández-Veledo
Title: Validació i estudi de valorització d’un nou mètode de selecció de cèl·lules mare mesenquimals (MSCs). R2B2018/07
Funding entity: URV Research bussiness
Duration: 2019
Principal Investigator: Sonia Fernández-Veledo
Title: A new probiotic strategy to improve metabolic and inflammatory profile in obese patients. SUCCIPRO.
Funding entity: Caixaimpulse. Fundación la Caixa.
Duration: 2019 – 2021
Principal Investigator: Isabel Huber
Title: DTS19/00040. New probiotic strategies for obesity-related disturbances and its companion diagnostic.
Funding entity:Instituto de salut Carlos III.
Duration: 2019 – 2021
Principal Investigator: Sonia Fernández Veledo
Title: Marato TV3: Mechanisms responsible for the defective differentiation capacity of adipose-derived stem cells in obesity: identification of new regulation amenable for the development of innovative therapies.
Funding entity: Fundació La Marató TV3.
Duration: 2017 – 2020
Principal Investigator: Sonia Fernández Veledo
Title: 2017 SGR 01440 Suport a Grups de Recerca (SGR) IISPV finançament – Grup de Recerca Emergent
Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca
Duration: 2017 – 2021
Principal Investigator: Sonia Fernández Veledo
Title: IU68-017106 Convocatoria dels ajuts d’industria del coneixements per a l’any 2019 (llavor i peoducte), susceptibles de ser confinçats, pel fons europeu de desenvolupament regional (FEDER) (REF.BDNS 458466).
Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca
Duration: 2020 – 2022
Principal Investigator: Sonia Fernández Veledo
Title: Ajuts per a projectes de valorització i transferència de coneixement desenvolupats per innovadors en estades en entitats del sistema de recerca i innovació de Catalunya (Innovadors 2019) AGAUR. PO FEDER CATALUNYA 2014 – 2020. Codi operació IU68-018623.
Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca
Duration: 2020 – 2022
Principal Investigator: Sonia Fernández Veledo
Title: HR20-00051 Research 2020 ‘Succinate / SUCNR1 Axis: A novel target for anti-obesity therapies’
Funding entity: Fundació Bancària Caixa d’Estalvis i Pensions de Barcelona
Duration: 2020 – 2023
Principal Investigator: Sonia Fernández Veledo
Title: 2017 SGR 01224 Suport a grups de recerca (SGR) URV – IISPV Finançament – Grup de recerca consolidat
Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca
Duration: 2017 – 2021
Principal Investigator: Joan Vendrell Ortega
Title: PI17/01503 Variabilidad Funcional de las Células madre Mesenquimales del tejido adiposo (ASCs) tras la pérdida de peso. Relación con metafactores vinculados a la microbiota intestinal.
Funding entity: Instituto Carlos III
Duration: 2018 – 2021
Principal Investigator: Joan Vendrell Ortega
Title: CI19-00055 New probiotic strategies for obesity-related disorders
Funding entity: Fundació Bancària Caixa d’Estalvis i Pensions de Barcelona
Duration: 2019 – 2021
Principal Investigator: Isabel Huber Ruano
Title: CB07/08/0012 CIBER
Funding entity: Instituto Carlos III
Duration: 2008 – 2025
Principal Investigator: Joan Vendrell Ortega
Title: Targeted interventions directed at reducing the levels of circulating succinate in a subject, and kits and method for determining effectiveness of said interventions.
Reference number: PCT/EP2019/051157.
Inventors: Sonia Fernández-Veledo; Joan Vendrell; Carolina Serena; Victoria Ceperuelo-Mallafré; Enrique Calvo.
Registration date: 2019
Title: Succinate as a biomarker for selecting a bariatric surgical procedure and for predicting type 2 diabetes mission after bariatric surgery.
Reference number: EP1938254.
Inventors:Sonia Fernández-Veledo; Joan Vendrell; Victoria Ceperuelo-Mallafré; Nuria Vilarrasa; Gemma Llauradó.
Registration date: 2019
Title: Targeted interventions directed at reducing the levels of circulating succinate ina a subject, and kits and method for determining effectiveness of said interventions.
Reference number: EP18382020.8.
Inventors:Sonia Fernández-Veledo; Joan Vendrell; Carolina serena; Victoria Ceperuelo-Mallafré
Registration date: 2018
Title: Methods for improving the cell therapy efficacy with mesenchymal stem cell populations España.
Reference number: EP17382615.7.
Inventors: Sonia Fernández-Veledo; Joan Vendrell; Carolina Serena; Antonio Zorzano.
Registration Date: 2017
Title: Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders.
Inventors: Mellitus SL (Joan Vendrell Ortega).
Registratiion Date: 2007
Title: Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease.
Inventors: Mellitus SL (Joan Vendrell Ortega).
Registration Date: 2005
Title: Use of soluble CD14 for treatment of diseases.
Inventors: Mellitus SL (Joan Vendrell Ortega).
Registration Date: 2004
Algaba-Chueca F, Maymó-Masip E, Ejarque M, Ballesteros M, Llauradó G, López C, Guarque A, Serena C, Martínez-Guasch L, Gutiérrez C, Bosch R, Vendrell J, Megía A, Fernández-Veledo S. Stem Cells Transl Med. 2020 Mar;9(3):351-363. Epub 2019 Dec 27. PMID: 31880859 Free PMC article.
Llauradó G, Amigó N, Cano A, Ballesta S, Albert L, Mazarico I, Fernández-Veledo S, Pedro-Botet J, Vendrell J, González-Clemente JM. J Clin Med. 2019 Nov 5;8(11):1875. PMID: 31694246 Free PMC article.
Guerrero-Pérez F, Casajoana A, Gómez-Vaquero C, Virgili N, López-Urdiales R, Hernández-Montoliu L, Pujol-Gebelli J, Osorio J, Alves C, Perez-Maraver M, Pellitero S, Vidal-Alabró A, Fernández-Veledo S, Vendrell J, Vilarrasa N. Obes Surg. 2020 Jan;30(1):180-188. PMID: 31420830 Clinical Trial.
Serena C, Millan M, Ejarque M, Saera-Vila A, Maymó-Masip E, Núñez-Roa C, Monfort-Ferré D, Terrón-Puig M, Bautista M, Menacho M, Martí M, Espin E, Vendrell J, Fernández-Veledo S. Clin Epigenetics. 2020 Apr 6;12(1):53. PMID: 32252817 Free PMC article.
Serena C, Queipo-Ortuño M, Millan M, Sanchez-Alcoholado L, Caro A, Espina B, Menacho M, Bautista M, Monfort-Ferré D, Terrón-Puig M, Núñez-Roa C, Maymó-Masip E, Rodriguez MM, Tinahones FJ, Espin E, Martí M, Fernández-Veledo S, Vendrell J. J Clin Med. 2020 Jul 31;9(8):2448. PMID: 32751800 Free PMC article.
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Ejarque M, Sabadell-Basallote J, Beiroa D, Calvo E, Keiran N, Nuñez-Roa C, Del Mar Rodríguez M, Sabench F, Del Castillo D, Jimenez V, Bosch F, Nogueiras R, Vendrell J, Fernández-Veledo S. Br J Pharmacol. 2020 Sep 28. Online ahead of print. PMID: 32986861
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López-Cano C, Gutiérrez-Carrasquilla L, Barbé F, Sánchez E, Hernández M, Martí R, Ceperuelo-Mallafre V, Dalmases M, Fernández-Veledo S, Vendrell J, Hernández C, Simó R, Lecube A. J Clin Med. 2020 Aug 13;9(8):2632. PMID: 32823749 Free PMC article.
doi: 10.3390/jcm9082632.
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Cano A, Llauradó G, Albert L, Mazarico I, Astiarraga B, González-Sastre M, Martínez L, Fernández-Veledo S, Simó R, Vendrell J, González-Clemente JM. J Clin Med. 2020 Jul 11;9(7):2192. PMID: 32664522 Free PMC article.
doi: 10.3390/jcm9072192.
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van de Wiele N, Neyra E, Firacative C, Gilgado F, Serena C, Bustamante B, Meyer W. Pathogens. 2020 Aug 18;9(8):665. Free PMC article.
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Torna la caminada solidària entre Perafort i els Garidells per contribuir a investigar la diabetis
L’empresa emergent catalana SUCCIPRO investiga nous fàrmacs per al Crohn, l’obesitat i la diabetis
Identifiquen una nova línia de probiòtics per tractar l’obesitat i la diabetis
Descobreixen noves vies per al tractament de malalties inflamatòries intestinals com el Crohn
Un estudi identifica noves vies que expliquen la relació entre la diabetis i el càncer
Responsable de Grup: Sonia Fernández-Veledo, PhD
A/e: sonia.fernandez@iispv.cat
Co- Responsable de grup: Joan Vendrell, MD, PhD
A/e: joan.vendrell@iispv.cat
Hospital Universitari de Tarragona Joan XXIII
Edifici Modular de Docència i Recerca, Planta 1
C/ Dr. Mallafré Guasch, 4
43007-Tarragona
Responsible: Dra. Rosa Mª Jorba Martín
Responsible: Dra. Mònica Bulló Bonet
Responsible: Dra. Rosa Solà Alberich
Responsible: Dra. Teresa Auguet Quintillà