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Study Group on Metabolic Diseases Associated with Insulin-Resistance (GEMMAIR)

METABOLIC AND NUTRITION DISEASES
OBESITY PATHOGENY BIOMARKERS THERAPEUTIC TARGETS NONALCOHOLIC FATTY LIVER DISEASE
TARGETS

GEMMAIR has a long history in the study of the pathophysiology of obesity and associated diseases. Currently, the group mainly focuses its research on the study of nonalcoholic fatty liver disease and its comorbidities, such as obesity, type 2 diabetes mellitus and metabolic syndrome, in order to define new molecular mechanisms involved in the disease, and to find possible biomarkers and potential therapeutic targets.

RESPONSIBLE

  • Dra. Teresa Auguet Quintillà

  • PRESENTATION
  • RESEARCH LINES
  • GROUP MEMBERS
  • PROJECTS
  • TRANSFER
  • PUBLICATIONS
  • CONTACT

The Study Group on Metabolic Diseases Associated with Insulin Resistance (in catalan GEMMAIR) is a clinical and basic research group formed by a multidisciplinary team. It is composed of medical and experimental research staff from the Hospital Universitari de Tarragona Joan XXIII and Hospital Universitari Sant Joan de Reus: internists, surgeons, pathologists, molecular biologists and laboratory technicians.

GEMMAIR has more than 25 years of experience in the study of chronic liver diseases and more than 15 years in the study of obesity and associated diseases. Also, GEMMAIR is accredited as a consolidated group by the Agency for Management of University and Research Grants (AGAUR) since 2009 and is a research group recognized by the Universitat Rovira i Virgili (URV).

GEMMAIR has carried out several collaborations at national and international level; in addition to having a strong link with the academic environment, since most of the members of the group are professors at the URV. A large number of doctoral theses and final degree and master’s projects have also been carried out, so GEMMAIR has experience in the training of junior research staff.

  • Study of cytokines and adipocytokines in the pathophysiology of obesity, metabolic syndrome and non-alcoholic fetge fat malaltia (MFGNA).
  • Gene expression, transcriptional factors and epigenetics in MFGNA.
  • I studied the metabolites derived from the microbiota at the MFGNA.
  • Omic sciences (metabolomics, miromics and proteomics) in the non-invasive diagnosis of non-alcoholic steatohepatitis.
  • Chemical sciences (metabolomics and proteomics) in the study of arteriosclerotic arterial plaque.
  • Prognostic biomarkers of COVID-19 in patients with obesity and/or metabolic syndrome.
  • Venous thromboembolic malaltia.

  • WASTEwater as a source of knowledge on SARS-CoV-2 and other potentially pandemic VIRuses: a One Health approach (VIRWASTE). AGAUR. 01/05/2021-31/12/2023. 316.000€.

  • Biomarcadores de pronóstico circulantes y celulares para la progresión de COVID19 enpacientes con infección por SARS-CoV-2 utilizando ciencia multiómica. AGAUR. FRANCISCO VIDAL MARSAL. (FUNDACIÓ PRIVADA IISPV). 30/03/2020-31/12/2020.
    201.070,79 €.

  • PI16/00498, Papel de la disbiosis intestinal en la patogenia de la enfermedad del hígado graso no alcohólico a través de la regulación de la homeostasis lipídica hepática. Instituto de Salud Carlos III. Maria Teresa Auguet Quintillà. URV. 01/01/2017-31/12/2019. 71.500€.

  • 2016PFR-URV-B2-72, Grup d’Estudi de Malalties Metabòliques associades a Insulin
    Resistència (GEMMAIR) Universitat Rovira i Virgili. Cristobal Manuel Richart Jurado.
    URV. 01/01/2017-30/06/2018. 6.572,17 €.

  • 2016PFR-URV-B2-72, Programa de suport als grups de recerca reconeguts. Grup d’Estudi
    de Malalties Metabòliques associades a Insulin Resistència (GEMMAIR) Universitat
    Rovira i Virgili. Cristobal Manuel Richart Jurado. URV. 01/01/2017- 31/12/2017.
    6.572,17 €.

  • 2015PFR-URV-B2-72, Grup d’Estudi de Malalties Metabòliques associades a Insulin
    Resistència (GEMMAIR) Universitat Rovira i Virgili. Cristobal Manuel Richart Jurado.URV.
    01/01/2015-31/12/2017. 6.839 €.

  • 2015PFR-URV-B2-72, Programa de suport als grups de recerca reconeguts. Grup d’Estudi
    de Malalties Metabòliques associades a Insulin Resistència (GEMMAIR) Universitat
    Rovira i Virgili. Cristobal Manuel Richart Jurado.URV. 01/01/2015- 31/12/2017. 6.839 €.

    Clinical trials:

  • A Phase IIb/III Randomized, Double-blind,Placebo-controlled Study to Evaluate the
    Safety and Efficacy of Cotadutide in Participants with Non-cirrhotic Non-alcoholic
    Steatohepatitis with Fibrosis (D5671C00006). AstraZenecaAB. Desde 2022. IP: Dr. David
    Riesco
  • Phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study to
    evaluate the efficacy and safety of recombinant human plasma gelsolin (RHUPGSN)
    added to standard of care for treatment of subjects with severe covid-19 pneumonia.
    Lipopharma Therapeutics SL
    Desde 2020. IP: Dra. T. Auguet
  • Safety and efficacy of favipipravir in COVID-19 patients with pneumonia. A randomized,
    double blind, placebo controlled study (FAVID01-20-SP).
    Ferrer Internacional, S.A.
    Desde 2020. IP: Dra. T. Auguet

    Year

    LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity

    Bertran, L.; Capellades, J.; Abelló, S.; Durán-Bertran, J.; Aguilar, C.; Martinez, S.; Sabench, F.; Correig, X.; Yanes, O.; Auguet, T.; Richart, C. LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity. Int. J. Mol. Sci. 2023, 24, 9789.

    https://doi.org/10.3390/ijms24129789

    LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus

    Auguet, T.; Bertran, L.; Capellades, J.; Abelló, S.; Aguilar, C.; Sabench, F.; del Castillo, D.; Correig, X.; Yanes, O.; Richart, C. LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2023, 24, 7761.

    https://doi.org/10.3390/ijms24097761

    Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity

    Barrientos-Riosalido, A.; Real, M.; Bertran, L.; Aguilar, C.; Martínez, S.; Parada, D.; Vives, M.; Sabench, F.; Riesco, D.; Castillo, D.D.; Richart, C.; Auguet, T. Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity. Int. J. Mol. Sci. 2023, 24, 1324.

    https://doi.org/10.3390/ijms24021324

    The Role of Olfactomedin 2 in the Adipose Tissue–Liver Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease

    Barrientos-Riosalido, A.; Bertran, L.; Vilaró-Blay, M.; Aguilar, C.; Martínez, S.; Paris, M.; Sabench, F.; Riesco, D.; Binetti, J.; Castillo, D.D.; Richart, C.; Auguet, T. The Role of Olfactomedin 2 in the Adipose Tissue–Liver Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2023, 24, 5221.

    https://doi.org/10.3390/ijms24065221

    Expression of STING in Women with Morbid Obesity and Nonalcoholic Fatty Liver Disease

    Bertran, L.; Adalid, L.; Vilaró-Blay, M.; Barrientos-Riosalido, A.; Aguilar, C.; Martínez, S.; Sabench, F.; del Castillo, D.; Porras, J.A.; Alibalic, A.; Richart, C.; Auguet, T. Expression of STING in Women with Morbid Obesity and Nonalcoholic Fatty Liver Disease. Metabolites 2023, 13, 496.

    https://doi.org/10.3390/metabo13040496

    Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

    Matuozzo, D., Talouarn, E., Marchal, A., […] Auguet, T., et al. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Med 15, 22 (2023).

    https://doi.org/10.1186/s13073-023-01173-8

    Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain. Global epidemiology. 4.

    Roso-Llorach, Albert; Serra-Picamal, Xavier; Cos, Francesc X; et al; Paredes, Roger.

    https://doi.org/10.1016/j.gloepi.2022.100071

    Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes. Processes. 10.

    Auguet, Teresa (AC); López-Dupla, Miguel; Ramos, Jessica; et al; Richart, Cristóbal.

    https://doi.org/10.3390/pr10010143

    Fetuin-A, inter-α-trypsin inhibitor, glutamic acid and ChoE (18:0) are key biomarkers in a panel distinguishing mild from critical coronavirus disease 2019 outcomes. Clinical and Translational Medicine. 12-1, pp.e704-e704.

    Reverté, Laia; Yeregui, Elena; Olona, Montserrat; et al; Auguet, Teresa; Study Group, COVIDOMICS.

    https://doi.org/10.1002/ctm2.704

    Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome. Journal of Personalized Medicine. 12-3.

    Perpiñan, Carles; Bertran, Laia; Terra, Ximena; et al; Auguet, Teresa; behalf of COVID-19 Study Group.

    https://doi.org/10.3390/jpm12030391

    Venous Thrombosis within 30 Days after Vaccination against SARS-CoV-2 in a Multinational Venous Thromboembolism Registry Viruses. 14-2.

    Bikdeli, Behnood; Jiménez, David; Demelo-Rodriguez, Pablo; et al; the RIETE Investigators, for.

    https://doi.org/10.3390/v14020178

    Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology

    Bertran, L.; Eigbefoh-Addeh, A.; Portillo-Carrasquer, M.; Barrientos-Riosalido, A.; Binetti, J.; Aguilar, C.; Ugarte Chicote, J.; Bartra, H.; Artigas, L.; Coma, M.; Richart, C.; Auguet, T. Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology. Biomedicines 2022, 10, 1315.

    https://doi.org/10.3390/biomedicines10061315

    NASH Presence is Associated with a Lower Weight Loss One and 2 Years After Bariatric Surgery in Women with Severe Obesity

    Sabench, F., Bertran, L., Vives, M. et al. NASH Presence is Associated with a Lower Weight Loss One and 2 Years After Bariatric Surgery in Women with Severe Obesity. OBES SURG 32, 3313–3323 (2022).

    https://doi-org.sabidi.urv.cat/10.1007/s11695-022-06175-w

    New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease

    Bertran, L.; Jorba-Martin, R.; Barrientos-Riosalido, A.; Portillo-Carrasquer, M.; Aguilar, C.; Riesco, D.; Martínez, S.; Vives, M.; Sabench, F.; Castillo, D.D.; Richart, C.; Auguet, T. New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2022, 23, 7442.

    https://doi.org/10.3390/ijms23137442

    Teresa Auguet, et al. The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

    Jérémy Manry, Paul Bastard, Adrian Gervais, […] Teresa Auguet, et al. The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 2022; 119 (21) e2200413119

    https://doi.org/10.1073/pnas.2200413119

    Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?

    Auguet, T.; Bertran, L.; Barrientos-Riosalido, A.; Fabregat, B.; Villar, B.; Aguilar, C.; Sabench, F. Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease? Int. J. Environ. Res. Public Health 2022, 19, 13495.

    https://doi.org/10.3390/ijerph192013495

    Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity

    Bertran, L.; Portillo-Carrasquer, M.; Barrientos-Riosalido, A.; Aguilar, C.; Riesco, D.; Martínez, S.; Culebradas, A.; Vives, M.; Sabench, F.; Castillo, D.D.; Richart, C.; Auguet, T. Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity. Int. J. Mol. Sci. 2022, 23, 9871.

    https://doi.org/10.3390/ijms23179871

    Demographic, clinical, and functional determinants of antithrombotic treatment in patients with nonvalvular atrial fibrillation. BMC Cardiovascular Disorders.

    Mostaza, Jose Maria; Suarez Carmen; et al; on behalf of the PERFILAR study investigators.

    https://doi.org/10.1186/s12872-021-02019-0

    X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. SCIENCE IMMUNOLOGY. 2021. 6-62.

    Asano, Takaki; Boisson, Bertrand; et al; Casanova Jean-Laurent.

    https://doi.org/10.1126/sciimmunol.abl4348

    Expression of Jejunal Taste Receptors in Women with Morbid Obesity. NUTRIENTS.

    Bertran L; Portillo-Carrasque M; Martinez S; et al; Auguet T.

    https://doi.org/10.3390/nu13072437

    Circulating Levels of Pro-Neurotensin and Its Relationship with Nonalcoholic Steatohepatitis and Hepatic Lipid Metabolism Metabolites.

    Villar, B; Bertran L; Aguilar C; et al; Auguet T.

    https://doi.org/10.3390/metabo11060373

    Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity. International Journal of Molecular Sciences.

    Bertran L; Portillo-Carrasquer M; Aguilar C; et al; Auguet T.

    https://doi.org/10.3390/ijms22136895

    The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease. International Journal of Molecular Sciences.

    Bertran L; Pastor A; Portillo-Carrasquer M; et al; Auguet T.

    https://doi.org/10.3390/ijms22105239

    Predictive Biomarkers of COVID-19 Severity in SARS-CoV-2 Infected Patients with Obesity and Metabolic Syndrome. Journal of Personalized Medicine.

    Perpiñan C; Bertran L; Terra X; et al; Auguet T.

    https://doi.org/10.3390/jpm11030227

    Rivaroxaban or apixaban in fragile patients with acute venous thromboembolism Thrombosis Research. 193, pp.160-165.

    J Trujillo-Santos; P Beroiz; et al.

    https://doi.org/10.1016/j.thromres.2020.10.001

    Venous Thromboembolism in Patients with Autoimmune Disorders: Findings from the RIETE Registry Angiology. 71-2, pp.131- 138.

    PR Sada; JJ López-Nuñez; A Samperiz; et al.

    https://doi.org/10.1177/0003319719875895

    Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. LIFE.

    Binetti J; Bertran L; Riesco D; et al; Auguet T.

    https://doi.org/10.3390/life10100245

    Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE. 2020. pp.423.

    Bastard, Paul; Rosen, Lyndsay B; et al; Casanova Jean-Laurent.

    https://doi.org/10.1126/science.abd4585

    Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. SCIENCE. 2020. pp.422.

    Zhang, Qian; Bastard, Paul; et al; Casanova Jean-Laurent.

    https://doi.org/10.1126/ science.abd4570

    Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver. Obesity. 28-8, pp.1487-1493.

    Auguet, Teresa; Bertran, Laia; Binetti, Jessica; et al; Richart, Cristóbal.

    https://doi.org/10.1002/oby.22873

    Implicaciones pronósticas del daño miocárdico en pacientes con y sin diagnóstico confirmado de COVID-19 atendidos en un hospital universitario. Rev Esp Cardiol.

    Alfredo Bardaji; Anna Carrasquer; Raul Sánchez-Giménez; et al; 2020.

    https://doi.org/10.1016/j.recesp.2020.08.009

    Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis. International Journal of Molecular Sciences. 21-11.

    Auguet, Teresa; Bertran, Laia; Binetti, Jessica; et al; Richart, Cristóbal.

    https://doi.org/10.3390/ijms21114189

    Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. LIFE.
    Binetti J, Bertran L, Riesco D, Aguilar C, Martínez S, Sabench F, Porras JA, Camaron J, Castillo DD, Richart C, Auguet T. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Life (Basel). 2020 Oct 16;10(10):245. PMID: 33081272; PMCID: PMC7603041.
    doi: 10.3390/life10100245.
    Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE. 2020. pp.423.

    Bastard, Paul; Rosen, Lyndsay B; et al; Casanova Jean-Laurent.

    https://doi.org/10.1126/science.abd4585

    Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. SCIENCE. 2020. pp.422.

    Zhang, Qian; Bastard, Paul; et al; Casanova Jean-Laurent.

    https://doi.org/10.1126/ science.abd4570

    Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver

    Auguet, Teresa; Bertran, Laia; Binetti, Jessica; et al; Richart, Cristóbal.

    https://doi.org/10.1002/oby.22873

    Rate and duration of hospitalisation for acute pulmonary embolism in the real-world clinical practice of different countries: analysis from the RIETE registry. 903624 – European Respiratory Journal. 53-2.

    Mastroiacovo D; Dentali F; di Micco P; et al. RIETE Investigators.

    https://doi.org/10.1183/13993003.01677-2018

    Circulating microbiota-derived metabolites: a “liquid biopsy?. International journal of obesity.

    Aragonès, G.; Colom Pellicer, M.; Aguilar, C.; et al; Auguet, T.

    https://doi.org/10.1038/s41366-019-0430-0

    D-dimer levels and risk of recurrence following provoked venous thromboembolism: findings from the RIETE registry. J Intern Med.

    O Avnery; M Martin; A Bura-Riviere; et al.

    https://doi.org/10.1111/joim.12969

    Venous Thromboembolism in Patients with Autoimmune Disorders: Findings from the RIETE Registry. Angyology. SAGE. pp.1- 8.

    PR Sada; JJ López-Nuñez; A Samperiz; et al.

    https://doi.org/10.1177/0003319719875895

    Circulating microbiota-derived metabolites: a “liquid biopsy?. International journal of obesity.

    Aragonès, G.; Colom Pellicer, M.; Aguilar, C.; et al; Auguet, T.

    https://doi.org/10.1038/s41366-019-0430-0

    Rate and duration of hospitalisation for acute pulmonary embolism in the real-world clinical practice of different countries: analysis from the RIETE registry

    Mastroiacovo D; Dentali F; di Micco P; et al. RIETE Investigators.

    https://doi.org/10.1183/13993003.01677-2018

    Venous Thromboembolism in Patients with Autoimmune Disorders: Findings from the RIETE Registry. Angyology. SAGE. pp.1- 8.

    PR Sada; JJ López-Nuñez; A Samperiz; et al.

    https://doi.org/10.1177/0003319719875895

    Gut Microbiota-Derived Mediators as Potential Markers in Nonalcoholic Fatty Liver Disease. Biomed Research International.

    Gemma Aragonès; Sergio González-García; Carmen Aguilar; Cristóbal Richart; Teresa Auguet. 2019.

    https://doi.org/10.1155/2019/8507583

    Low circulating levels of neurotensin in women with non-alcoholic fatty liver disease associated to severe obesity. Obesity. 26-2, pp.274-278.

    Auguet T; Aragonès G; Berlanga A; et al; Richart C. 2018.

    https://doi.org/10.1002/oby.22058

    Real-life Use of Anticoagulants in Venous Thromboembolism with a Focus on Patients with Exclusion Criteria for Direct Oral Anticoagulants Clinical Pharmacology & Therapeutics. 103-4, pp.684-691.

    Moustafa, Farès; Pesavento, Raffaele; di Micco, Pierpaolo; et al; RIETE Investigators, the.

    https://doi.org/10.1002/cpt.781

    Anemia and bleeding in patients receiving anticoagulant therapy for venous thromboembolism

    Kuperman A; López-Reyes R; Bosco LJ; et al; RIETE Investigators.

    https://doi.org/10.1007/s11239-018-1610-9

    Characteristics, treatment patterns and outcomes of patients presenting with venous thromboembolic events after knee arthroscopy in the RIETE Registry.910696 Journal of Thrombosis and Thrombolysis. 46-4, pp.551-558.

    Weinberg I; Giri J; Kolluri R; et al; RIETE Investigators. 2018.

    https://doi.org/10.1007/s11239-018-1736-9

    Thirty-day outcomes in patients with acute pulmonary embolism who discontinued anticoagulant therapy before 90 days 900566 – American Heart Journal. 206, pp.1-10.

    Nieto JA; Vicente JA; Prieto LM; et al; RIETE Investigators.

    https://doi.org/10.1016/j.ahj.2018.08.014

    Targeted metabolomic approach in men with carotid plaque. Plos One. 13.

    Auguet T; Aragonès G; Colom M; Aguilar C; Martín-Paredero V; Canela N; Ruyra X; Richart C.

    https://doi.org/10.1371/journal.pone.0200547

    Development of a Risk Prediction Score for Occult Cancer in Patients With VTE. CHEST. 151-3, pp.564.

    ara-Palomares, L.; Otero, R.; Jimenez, D.; et al; Mazzolai,L. 2017.

    https://doi.org/10.1016/j.chest.2016.10.025

Team Members

  • Group responsible

    • Dra. Teresa Auguet Quintillà

  • Clinical Researchers

    • Marta París Sans
    • Margarida Vives Espelta
    • Fàtima Sabench Pereferrer
    • Dr. Daniel del Castillo Déjardin
    • José Antonio Porras Ledante
    • David Riesco Acevedo
    • Salomé Martínez González
    • Jessica Binetti
    • Ajla Alibalic

  • Emeritus Researcher

    • Cristóbal Manuel Richart Jurado

  • Post-doctoral researchers

    • Javier Ugarte Chicote
    • Laia Bertran Ramos

  • Pre-doctoral researchers

    • Razie Mahmoodian

  • Bioinformatics

    • Elena Cristina Rusu Hutu

  • Laboratory technicians

    • Carmen Aguilar Crespillo
    • Andrea Barrientos Riosalido

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