GEMMAIR has a long history in the study of the pathophysiology of obesity and associated diseases. Currently, the group mainly focuses its research on the study of nonalcoholic fatty liver disease and its comorbidities, such as obesity, type 2 diabetes mellitus and metabolic syndrome, in order to define new molecular mechanisms involved in the disease, and to find possible biomarkers and potential therapeutic targets.
Dra. Teresa Auguet Quintillà
The Study Group on Metabolic Diseases Associated with Insulin Resistance (in catalan GEMMAIR) is a clinical and basic research group formed by a multidisciplinary team. It is composed of medical and experimental research staff from the Hospital Universitari de Tarragona Joan XXIII and Hospital Universitari Sant Joan de Reus: internists, surgeons, pathologists, molecular biologists and laboratory technicians.
GEMMAIR has more than 25 years of experience in the study of chronic liver diseases and more than 15 years in the study of obesity and associated diseases. Also, GEMMAIR is accredited as a consolidated group by the Agency for Management of University and Research Grants (AGAUR) since 2009 and is a research group recognized by the Universitat Rovira i Virgili (URV).
GEMMAIR has carried out several collaborations at national and international level; in addition to having a strong link with the academic environment, since most of the members of the group are professors at the URV. A large number of doctoral theses and final degree and master’s projects have also been carried out, so GEMMAIR has experience in the training of junior research staff.
An open, multicentre, prospective, non-interventional study of the CE-marked medical device GlucoTab, according to intended use without additional invasive and stressful measures with a matched retrospective control group. Project Grant Agreement EIT Health. IP: Maria Teresa Auguet Quintillà. 2024-2025
Consumption of grapes with different (poly)phenol content in the adaptation to photoperiod. PROYECTOS DE GENERACIÓN DE CONOCIMIENTO 2023 PLAN ESTATAL. IP: Begoña Muguerza i Anna Arola Arnal. 2023-2027
Microplastics: Dietary intake, impact on gut and promotion on liver damage (MP-DiGuLi). PROYECTOS DE GENERACIÓN DE CONOCIMIENTO 2022 PLAN ESTATAL. IP: Martí Nadal i Joaquim Rovira. IISPV. 2024-2027. 252.250,00€
WASTEwater as a source of knowledge on SARS-CoV-2 and other potentially pandemic VIRuses: a One Health approach (VIRWASTE). AGAUR. 01/05/2021-31/12/2023. 316.000€.
Biomarcadores de pronóstico circulantes y celulares para la progresión de COVID19 enpacientes con infección por SARS-CoV-2 utilizando ciencia multiómica. AGAUR. FRANCISCO VIDAL MARSAL. (FUNDACIÓ PRIVADA IISPV). 30/03/2020-31/12/2020.
201.070,79 €.
PI16/00498, Papel de la disbiosis intestinal en la patogenia de la enfermedad del hígado graso no alcohólico a través de la regulación de la homeostasis lipídica hepática. Instituto de Salud Carlos III. Maria Teresa Auguet Quintillà. URV. 01/01/2017-31/12/2019. 71.500€.
2016PFR-URV-B2-72, Grup d’Estudi de Malalties Metabòliques associades a Insulin
Resistència (GEMMAIR) Universitat Rovira i Virgili. Cristobal Manuel Richart Jurado.
URV. 01/01/2017-30/06/2018. 6.572,17 €.
2016PFR-URV-B2-72, Programa de suport als grups de recerca reconeguts. Grup d’Estudi
de Malalties Metabòliques associades a Insulin Resistència (GEMMAIR) Universitat
Rovira i Virgili. Cristobal Manuel Richart Jurado. URV. 01/01/2017- 31/12/2017.
6.572,17 €.
2015PFR-URV-B2-72, Grup d’Estudi de Malalties Metabòliques associades a Insulin
Resistència (GEMMAIR) Universitat Rovira i Virgili. Cristobal Manuel Richart Jurado.URV.
01/01/2015-31/12/2017. 6.839 €.
2015PFR-URV-B2-72, Programa de suport als grups de recerca reconeguts. Grup d’Estudi
de Malalties Metabòliques associades a Insulin Resistència (GEMMAIR) Universitat
Rovira i Virgili. Cristobal Manuel Richart Jurado.URV. 01/01/2015- 31/12/2017. 6.839 €.
Arto, C., Rusu, E. C., Clavero-Mestres, H., Barrientos-Riosalido, A., Bertran, L., Mahmoudian, R., Aguilar, C., Riesco, D., Ugarte Chicote, J., Parada, D., Martínez, S., Sabench, F., Richart, C., & Auguet, T. (2024). Metabolic profiling of tryptophan pathways: Implications for obesity and metabolic dysfunction‐associated steatotic liver disease. Eur J Clin Invest. 2024;00:e14279. https://doi.org/10.1111/eci.14279
Rusu, E. C., Monfort-Lanzas, P., Bertran, L., Barrientos-Riosalido, A., Solé, E., Mahmoudian, R., Aguilar, C., Briansó, S., Mohamed, F., Garcia, S., Camaron, J., & Auguet, T. (2024). Towards understanding post-COVID-19 condition: A systematic meta-analysis of transcriptomic alterations with sex-specific insights. Computers in biology and medicine, 175, 108507. https://doi.org/10.1016/j.compbiomed.2024.108507
Duran-Bertran, J., Rusu, E. C., Barrientos-Riosalido, A., Bertran, L., Mahmoudian, R., Aguilar, C., Riesco, D., Martínez, S., Ugarte Chicote, J., Sabench, F., Richart, C., & Auguet, T. (2024). Platelet-associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity. European journal of clinical investigation, 54(3), e14123. https://doi.org/10.1111/eci.14123
Bertran, L., Capellades, J., Abelló, S., Aguilar, C., Auguet, T., & Richart, C. (2024). Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study. PloS one, 19(5), e0303569. https://doi.org/10.1371/journal.pone.0303569
Bertran, L.; Capellades, J.; Abelló, S.; Durán-Bertran, J.; Aguilar, C.; Martinez, S.; Sabench, F.; Correig, X.; Yanes, O.; Auguet, T.; Richart, C. LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity. Int. J. Mol. Sci. 2023, 24, 9789.
Auguet, T.; Bertran, L.; Capellades, J.; Abelló, S.; Aguilar, C.; Sabench, F.; del Castillo, D.; Correig, X.; Yanes, O.; Richart, C. LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2023, 24, 7761.
Barrientos-Riosalido, A.; Real, M.; Bertran, L.; Aguilar, C.; Martínez, S.; Parada, D.; Vives, M.; Sabench, F.; Riesco, D.; Castillo, D.D.; Richart, C.; Auguet, T. Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity. Int. J. Mol. Sci. 2023, 24, 1324.
Barrientos-Riosalido, A.; Bertran, L.; Vilaró-Blay, M.; Aguilar, C.; Martínez, S.; Paris, M.; Sabench, F.; Riesco, D.; Binetti, J.; Castillo, D.D.; Richart, C.; Auguet, T. The Role of Olfactomedin 2 in the Adipose Tissue–Liver Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2023, 24, 5221.
Bertran, L.; Adalid, L.; Vilaró-Blay, M.; Barrientos-Riosalido, A.; Aguilar, C.; Martínez, S.; Sabench, F.; del Castillo, D.; Porras, J.A.; Alibalic, A.; Richart, C.; Auguet, T. Expression of STING in Women with Morbid Obesity and Nonalcoholic Fatty Liver Disease. Metabolites 2023, 13, 496.
Matuozzo, D., Talouarn, E., Marchal, A., […] Auguet, T., et al. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Med 15, 22 (2023).
Roso-Llorach, Albert; Serra-Picamal, Xavier; Cos, Francesc X; et al; Paredes, Roger.
Auguet, Teresa (AC); López-Dupla, Miguel; Ramos, Jessica; et al; Richart, Cristóbal.
Reverté, Laia; Yeregui, Elena; Olona, Montserrat; et al; Auguet, Teresa; Study Group, COVIDOMICS.
Perpiñan, Carles; Bertran, Laia; Terra, Ximena; et al; Auguet, Teresa; behalf of COVID-19 Study Group.
Bikdeli, Behnood; Jiménez, David; Demelo-Rodriguez, Pablo; et al; the RIETE Investigators, for.
Bertran, L.; Eigbefoh-Addeh, A.; Portillo-Carrasquer, M.; Barrientos-Riosalido, A.; Binetti, J.; Aguilar, C.; Ugarte Chicote, J.; Bartra, H.; Artigas, L.; Coma, M.; Richart, C.; Auguet, T. Identification of the Potential Molecular Mechanisms Linking RUNX1 Activity with Nonalcoholic Fatty Liver Disease, by Means of Systems Biology. Biomedicines 2022, 10, 1315.
Sabench, F., Bertran, L., Vives, M. et al. NASH Presence is Associated with a Lower Weight Loss One and 2 Years After Bariatric Surgery in Women with Severe Obesity. OBES SURG 32, 3313–3323 (2022).
Bertran, L.; Jorba-Martin, R.; Barrientos-Riosalido, A.; Portillo-Carrasquer, M.; Aguilar, C.; Riesco, D.; Martínez, S.; Vives, M.; Sabench, F.; Castillo, D.D.; Richart, C.; Auguet, T. New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2022, 23, 7442.
Jérémy Manry, Paul Bastard, Adrian Gervais, […] Teresa Auguet, et al. The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies 2022; 119 (21) e2200413119
Auguet, T.; Bertran, L.; Barrientos-Riosalido, A.; Fabregat, B.; Villar, B.; Aguilar, C.; Sabench, F. Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease? Int. J. Environ. Res. Public Health 2022, 19, 13495.
Bertran, L.; Portillo-Carrasquer, M.; Barrientos-Riosalido, A.; Aguilar, C.; Riesco, D.; Martínez, S.; Culebradas, A.; Vives, M.; Sabench, F.; Castillo, D.D.; Richart, C.; Auguet, T. Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity. Int. J. Mol. Sci. 2022, 23, 9871.
Mostaza, Jose Maria; Suarez Carmen; et al; on behalf of the PERFILAR study investigators.
Asano, Takaki; Boisson, Bertrand; et al; Casanova Jean-Laurent.
Bertran L; Portillo-Carrasque M; Martinez S; et al; Auguet T.
Villar, B; Bertran L; Aguilar C; et al; Auguet T.
Bertran L; Portillo-Carrasquer M; Aguilar C; et al; Auguet T.
Bertran L; Pastor A; Portillo-Carrasquer M; et al; Auguet T.
Perpiñan C; Bertran L; Terra X; et al; Auguet T.
J Trujillo-Santos; P Beroiz; et al.
PR Sada; JJ López-Nuñez; A Samperiz; et al.
Binetti J; Bertran L; Riesco D; et al; Auguet T.
Bastard, Paul; Rosen, Lyndsay B; et al; Casanova Jean-Laurent.
Zhang, Qian; Bastard, Paul; et al; Casanova Jean-Laurent.
Auguet, Teresa; Bertran, Laia; Binetti, Jessica; et al; Richart, Cristóbal.
Alfredo Bardaji; Anna Carrasquer; Raul Sánchez-Giménez; et al; 2020.
Auguet, Teresa; Bertran, Laia; Binetti, Jessica; et al; Richart, Cristóbal.
Bastard, Paul; Rosen, Lyndsay B; et al; Casanova Jean-Laurent.
Zhang, Qian; Bastard, Paul; et al; Casanova Jean-Laurent.
Auguet, Teresa; Bertran, Laia; Binetti, Jessica; et al; Richart, Cristóbal.
Mastroiacovo D; Dentali F; di Micco P; et al. RIETE Investigators.
Aragonès, G.; Colom Pellicer, M.; Aguilar, C.; et al; Auguet, T.
O Avnery; M Martin; A Bura-Riviere; et al.
PR Sada; JJ López-Nuñez; A Samperiz; et al.
Aragonès, G.; Colom Pellicer, M.; Aguilar, C.; et al; Auguet, T.
Mastroiacovo D; Dentali F; di Micco P; et al. RIETE Investigators.
PR Sada; JJ López-Nuñez; A Samperiz; et al.
Gemma Aragonès; Sergio González-García; Carmen Aguilar; Cristóbal Richart; Teresa Auguet. 2019.
Auguet T; Aragonès G; Berlanga A; et al; Richart C. 2018.
Moustafa, Farès; Pesavento, Raffaele; di Micco, Pierpaolo; et al; RIETE Investigators, the.
Kuperman A; López-Reyes R; Bosco LJ; et al; RIETE Investigators.
Weinberg I; Giri J; Kolluri R; et al; RIETE Investigators. 2018.
Nieto JA; Vicente JA; Prieto LM; et al; RIETE Investigators.
Auguet T; Aragonès G; Colom M; Aguilar C; Martín-Paredero V; Canela N; Ruyra X; Richart C.
ara-Palomares, L.; Otero, R.; Jimenez, D.; et al; Mazzolai,L. 2017.