Functional Nutrition, Oxidation and Cardiovascular Diseases (NFOC-HEALTH)


NFOC-SALUT works mainly in the field of health, lifestyle and cardiovascular diseases, from an experimental, clinical and applied approach to society in the academic and health promotion environment. Our research team is made up of professionals from multidisciplinary fields in Health Sciences: doctors, dietitians-nutritionists, biologists, food technologists and full-time pharmacists, postdoctoral researchers and doctoral students.

  • Dra. Rosa Solà Alberich

  • Presentation
  • Research lines
  • Group Members
  • Projects
  • Publications
  • Contact

The NFOC-health group is a group recognized by the Generalitat de Catalunya: 2017 SGR 00522 – Functional Nutrition, Oxidation and Cardiovascular Disease Research Group (NFOC-health). In recent years, our group has gained considerable experience in intervention studies, both in humans and animals, in the clinical field and also in the field of health promotion. As well as in the development of studies in cell cultures. In addition, the close collaboration of this group with the Nutrition and Health Unit of the Eurecat technology center is also noteworthy.

On the other hand, our group has been actively involved in research into the beneficial effects of different components of the diet on cardiovascular disease both in vivo and in vitro. In recent years, the research team has carried out various studies in the different areas in which it works.

In addition, we participate in different European competitive projects such as PREVENTOMICS (precision nutrition study), NESTORE (study to improve the health of the elderly), and MED4Youth (nutritional study to reduce obesity in adolescents) . We have also led the international competitive project CITRUS (effect of hesperidin on different markers of cardiovascular disease).

In the field of health promotion, he has participated in different European projects in teenagers (EYTO) and in catering (TURISTIC in FAMILY).

At the state level, we are currently leading the PID2019-105164RB-I00 project entitled FOOP-Sarc, (a nutritional study based on functional virgin olive oil enriched with phenolic compounds and yogurt enriched with probiotics to address sarcopenia). In addition, the group has led different competitive projects such as: PERIS SLT 002/016/155 (study on the effect of the Mediterranean Diet on lung function in smokers without previous respiratory pathology), AGL2017 AppleCor (cardiometabolic effects of anthocyanins of red apples), AGL2012 MEFOPC (Metabolism and bioactivity of phenolic compounds in olive oil in humans), AGL2009 VOHF (Extra virgin olive oil and HDL functionality), AGL2005 OLIPA (Enriched virgin olive oil with polyphenols) and AGL2009-12374-C03-02. 2010-2012 (Marine omega-3s, polyphenols and phagomine in the metabolic syndrome).

In the field of health promotion, he has led a national competitive project (EYTO-Kids) to promote health in schoolchildren to improve their lifestyles.

Beyond the experience in, the supervision of the advice of participants, preparation and maintenance of databases and advanced statistics, and in the handling of cell cultures, manipulation of animals, the group has acquired proven experience in the field of omics, in both proteomics, metabolomics, lipidomics, and metagenomics.

On the other hand, we teach the degree in Medicine, Human Nutrition and Dietetics, Physiotherapy, Nursing, Biomedical Engineering and the double degree in Biomedical and Systems Engineering. In addition, the master’s degree in Aging and Health and the master’s degree in Nutrition and Metabolism at Rovira i Virgili University.

  • Nutritional intervention studies in accordance with the criteria of nutritional and scientific quality CONSORT, STROBE, PRISMA, TIDIER, etc .; and the appropriate ethical norms, in healthy people and affections of diverse pathologies like the alterations of the lipids, the arterial hypertension, etc.
  • Nutritional intervention studies in healthy animal models and effects of various pathologies such as metabolic syndrome.
  • Studies of diagnostic markers, functionality and mechanisms of action: oxidative stress, inflammation, etc., both in in vitro cell cultures and in in vivo animal and human animal models.
  • Studies of markers of consumption and bioavailability in experimental animals and humans.
  • In vitro and in vivo toxicological studies.
  • Health education studies in healthy lifestyles (nutrition and physical activity) in primary and secondary schools, and in other areas of the community.

  • TurisTIC- Healthy meals (PECT TurísTIC in family. European Regional Development Fund (FEDER) of European Union, under the umbrella of FEDER Catalonia 2014-2020.GAH/815/2018. 2017-2020. IP: Rosa Solà..

  • Efecte de la Dieta Mediterrània sobre la funció pulmonar en fumadors sense patologia respiratòria prèvia: l’assaig clínic MEDIS (Mediterranean Diet and Smoking). PERIS: SLT 002/016/155. 2017-2019. IP: Dr. Francisco Martín Luján i Rosa Solà.

  • Suplementación de antocianinas a través de manzana de pulpa roja o extracto de antocianina: mecanismos de acción y efectos cardiometabolicos en sujetos hipercolesterolémicos cardiometabólico: un enfoque proteómico. AGL2016-76943-C2. 2017-2020. IP: Rosa Maria Solà Alberich.Cofinanciado por el Ministerio de Economía, Indústria y Competitividad (MINECO), la Agencia Estatal de Investigación (AEI) y Fondo Europeo de Desarrollo Regional (FEDER).

  • Application of the personalized nutrition based on metabotypes for the enhancement of the beneficial effects of a diet rich in flavonoids in hypertensive individuals. PRI2019-FLAVOTIP.   2019-2021. IP: Noemí Boqué. Eurecat, Centre Tecnològic de Catalunya. Convocatòria Pla de Recerca i Innovació.  

  • Aceites polares de origen marino como fuente de PUFA omega-3 y mediadores lipídicos para un envejecimiento saludable: regulación de la inflamación y desequilibrio oxidativo (MarPL-WellAging). RTI2018-095659-B100. 2019-2022. IP: Isabel Medina. Financiado por: Ministerio de Economía y Competitividad. Programa Estatal de Investigación, Desarrollo e Innovación orientada a los retos de la Sociedad.

  • Efecto funcional de iminoazúcares naturales en un modelo animal de prediabetes inducida por dieta. Del mecanismo de acción al diseño de alimentos. AGL2017-83599-R. IP: Josep Lluís Torres. Cofinanciado por el Ministerio de Economía, Indústria y Competitividad (MINECO), la Agencia Estatal de Investigación (AEI) y Fondo Europeo de Desarrollo Regional (FEDER).


    Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis

    Companys J, Pla-Pagà L, Calderón-Pérez L, Llauradó E, Solà R, Pedret A, Valls RM.
    Adv Nutr. 2020 Jul 1;11(4):834-863.

    DOI: 10.1093/advances/nmaa030

    Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo

    Cedó L, Fernández-Castillejo S, Rubió L, Metso J, Santos D, Muñoz-Aguayo D, Rivas-Urbina A, Tondo M, Méndez-Lara KA, Farràs M, Jauhiainen M, Motilva MJ, Fitó M, Blanco-Vaca F, Solà R, Escolà-Gil JC.
    Biomedicines. 2020 Aug 3;8(8):266.

    DOI: 10.3390/biomedicines8080266

    Response to: Comment About Statistical Analysis of a Cluster-Randomized Trial About Clustering and Nesting (DOI: 10.1089/chi.2019.0142)

    Aceves-Martins M, Llauradó E, Tarro L, Moriña D, Papell-Garcia I, Prades-Tena J, Kettner-Høeberg H, Puiggròs F, Arola L, Davies A, Giralt M, Solà R.
    Child Obes. 2020 Mar;16(2):67-69.

    DOI: 10.1089/chi.2019.0265

    Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal studies

    Sandoval-Ramírez BA, Catalán Ú, Pedret A, Valls RM, Motilva MJ, Rubió L, Solà R.
    2020 Oct 15 [Epub ahead of print].Clin Nutr.

    DOI: 10.1016/j.clnu.2020.09.027

    The effects and associations of whole-apple intake on diverse cardiovascular risk factors. A narrative review

    Sandoval-Ramírez BA, Catalán Ú, Calderón-Pérez L, Companys J, Pla-Pagà L, Ludwig IA, Romero MP, Solà R.
    Crit Rev Food Sci Nutr. 2020;60(22):3862-3875.

    DOI: 10.1080/10408398.2019.1709801

    Fermented dairy foods rich in probiotics and cardiometabolic risk factors: a narrative review from prospective cohort studies

    Companys J, Pedret A, Valls RM, Solà R, Pascual V.
    2020 May 21 [Epub ahead of print].Crit Rev Food Sci Nutr.

    DOI: 10.1080/10408398.2020.1768045

    Mobile Phone Apps for Food Allergies or Intolerances in App Stores: Systematic Search and Quality Assessment Using the Mobile App Rating Scale (MARS)

    Mandracchia F, Llauradó E, Tarro L, Valls RM, Solà R.
    JMIR Mhealth Uhealth. 2020 Sep 16;8(9):e18339.

    DOI: 10.2196/18339

    Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

    Pla-Pagà L, Guirro M, Gual-Grau A, Gibert-Ramos A, Foguet-Romero E, Catalán Ú, Mayneris-Perxachs J, Canela N, Valls RM, Arola L, Solà R, Pedret A.
    Mol Nutr Food Res. 2020 May;64(10):e1901063.

    DOI: 10.1002/mnfr.201901063

    Impact of Phenol-Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease

    Daimiel L, Micó V, Valls RM, Pedret A, Motilva MJ, Rubió L, Fitó M, Farrás M, Covas MI, Solá R, Ordovás JM.
    Mol Nutr Food Res. 2020 Aug;64(15):e2000049.

    DOI: 10.1002/mnfr.202000049

    Cyanidin-3-glucoside as a possible biomarker of anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials

    Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R.
    Nutr Rev. 2020 Jul 1;78(7):597-610.

    DOI: 10.1093/nutrit/nuz083

    Social and Economic Factors and Malnutrition or the Risk of Malnutrition in the Elderly: A Systematic Review and Meta-Analysis of Observational Studies

    Besora-Moreno M, Llauradó E, Tarro L, Solà R.
    Nutrients. 2020 Mar 11;12(3):737.

    DOI: 10.3390/nu12030737

    Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in Catalonia, Spain

    Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA.
    Radiother Oncol. 2020 Oct;151:200-205.

    DOI: 10.1016/j.radonc.2020.08.002

    Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study

    Calderón-Pérez L, Gosalbes MJ, Yuste S, Valls RM, Pedret A, Llauradó E, Jimenez-Hernandez N, Artacho A, Pla-Pagà L, Companys J, Ludwig I, Romero MP, Rubió L, Solà R.
    Sci Rep. 2020 Apr 15;10(1):6436.

    DOI: 10.1038/s41598-020-63475-w

    Effectiveness of Workplace Interventions for Improving Absenteeism, Productivity, and Work Ability of Employees: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Tarro L, Llauradó E, Ulldemolins G, Hermoso P, Solà R.
    Int J Environ Res Public Health. 2020 Mar 14;17(6):1901

    DOI: 10.3390/ijerph17061901

    Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial

    Calderón-Pérez L, Llauradó E, Companys J, Pla-Pagà L, Boqué N, Puiggrós F, Valls RM, Pedret A, Llabrés JM, Arola L, Solà R.
    2020 Jul 29 [Epub ahead of print].J Med Food.

    DOI: 10.1089/jmf.2020.0074

    Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis: A study protocol

    Soriano-Arandes A, Caylà JA, Gonçalves AQ, Orcau À, Noguera-Julian A, Padilla E, Solà-Segura E, Gordillo NR, Espiau M, García-Lerín MG, Rifà-Pujol MÀ, Jordi Gómez I Prat, Macia-Rieradevall E, Martin-Nalda A, Eril-Rius M, Santos Santiago J, Busquets-Poblet L, Martínez RM, Pérez-Porcuna TM.
    Medicine (Baltimore). 2020 Sep 4;99(36):e22015.

    DOI: 10.1097/MD.0000000000022015

    Aqueous StableGold Nanostar/ZIF-8 Nanocomposites for Light-Triggered Release of Active CargoInside Living Cells

    Carrillo-Carrión C, Martínez R, Navarro Poupard MF, Pelaz B, Polo E, Arenas-Vivo A, Olgiati A, Taboada P, Soliman MG, Catalán Ú, Fernández-Castillejo S, Solà R, Parak WJ, Horcajada P, Alvarez-Puebla RA, Del Pino P. Angew Chem Int Ed Engl.

    DOI: 10.1002/anie.201902817

    Endothelial Cells Deconjugate Resveratrol Metabolites to Free Resveratrol: A Possible Role inTissue Factor Modulation

    Mol Nutr Food Res

    DOI: 10.1002/mnfr.201800715

    Potential Use of Mobile Phone Applications forSelf-Monitoring and Increasing Daily Fruit and Vegetable Consumption: ASystematized Review

    Mandracchia F, Llauradó E, Tarro L, Del Bas JM, Valls RM, Pedret A, Radeva P, Arola L, Solà R, Boqué N. Nutrients.

    DOI: 10.3390/nu11030686

    Impact of a youth-led social marketing intervention run byadolescents to encourage healthy lifestyles among younger school peers (EYTO-Kidsproject): a parallel-cluster randomised controlled pilot study

    Tarro L, Llauradó E, Aceves-Martins M, Moriña D, Papell-Garcia I, Arola L, Giralt M, Solà R. J EpidemiolCommunity Health

    DOI: 10.1136/jech-2017-210163

    Effects of daily consumptionof the probiotic Bifidobacterium animalis subsp lactis CECT 8145 onanthropometric adiposity biomarkers in abdominally obese subjects: a randomizedcontrolled trial

    Pedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Pla-Pagà L, Moragas A, Martín-Luján F, Ortega Y, Giralt M, Caimari A, Chenoll E, Genovés S, Martorell P, Codoñer FM, Ramón D, Arola L, Solà R. Int J Obes (Lond)

    DOI: 10.1038/s41366-018-0220-0

    Cyanidin-3-glucoside as a possible biomarker of anthocyanin-rich berryintake in body fluids of healthy humans: a systematic review of clinical trials

    Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R. Nutr Rev.

    DOI: 10.1093/nutrit/nuz083

    A Functional Virgin Olive OilEnriched with Olive Oil and Thyme Phenolic Compounds Improves the Expression ofCholesterol Efflux-Related Genes: A Randomized, Crossover, Controlled Trial

    Farràs M, Arranz S, Carrión S, Subirana I, Muñoz-Aguayo D, Blanchart G, Kool M, Solà R, Motilva MJ, Escolà-Gil JC, Rubió L, Fernández-Castillejo S, Pedret A, Estruch R, Covas MI, Fitó M, Hernáez Á, Castañer O.

    DOI: 10.3390/nu11081732

    Dietary recommendations in the prevention of cardiovascular disease.

    Lewis B. Clin Investig Arterioscler.

    DOI: 10.1007/BF02024690

    Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetis risk factors in rats fed a high-fat diet.

    Hereu M, Ramos-Romero S, Busquets C, Atienza L, Amézqueta S, Miralles-Pérez B, Nogués MR, Méndez L, Medina I, Torres JL. Effects of combined D-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet. Sci Rep.

    DOI: 10.1038/s41598-019-52678-5

    Effects of hesperidin consumption on cardiovascular risk biomarkers: a systematic review of animal studies and human randomized clinical trials

    L Pla-Pagà, J Companys, L Calderón-Pérez, E Llauradó, R Solà, R M Valls, A Pedret, Nutr Rev

    DOI: 10.1093/nutrit/nuz036

    A clinical trial to evaluate the effect of theMediterranean diet on smokers lung function

    Martín-Luján, F., Catalin, RE., Salamanca-González, P. et al. A clinical trial to evaluate the effect of the Mediterranean diet on smokers lung function. npj Prim. Care Respir. Med. 29, 40 (2019)

    DOI: 10.1038/s41533-019-0153-7

    Involving young people in health promotion, research and policy-making: practical recommendations.

    Magaly Aceves-Martins, Aixa Y Aleman-Diaz, Montse Giralt, Rosa Solà Int J Qual Health Care

    DOI: 10.1093/intqhc/mzy113

Team Members

  • Group Leader

    • Dra. Rosa Solà Alberich
  • Senior Researcher

    • Marta Romeu Ferran
    • Maria Rosa Nogués Llort
    • Montserrat Giralt Batista
  • Postdoctoral Researcher

    • Anna Pedret Figuerola
    • Lucía Tarro Sánchez
    • Núria Taltavull Anglada
    • Elisabet Llauradó Ribé
    • Úrsula Catalán Santos
    • Rosa M. Valls Zamora
  • PhD Student

    • Bernat Miralles Pérez
    • Laura Pla Pagà
    • Berner Andrée, Sandoval Ramírez
    • Floriana Mandracchia
    • Patricia Salamanca Gonzalez
    • Judit Companys Alemany
    • Lorena Calderón Pérez
  • Technician

    • Vanessa Sánchez Martos