The research group aims to study the bioactivity of food in the gastrointestinal tract, ie to assess how different components of our diet can adversely or beneficially affect our gut, and how this interaction can influence the health. of the rest of the body. Within our lines of study, we emphasize the characterization at the molecular level of the interaction of components of the diet with the enteroendocrine system, the ability of these compounds to modify the integrity of the intestinal barrier and its immunomodulatory effect, as well as the study of alterations of the intestinal microbiota caused by certain foods, the analysis of the epigenetic effects of different bioactive compounds in situations of metabolic stress such as obesity or aging and the study of the effect of sources alternatives of high nutritional quality and more environmentally sustainable proteins.

  • Dra. Montse Pinent Grau

  • Presentation
  • Research lines
  • Group members
  • Projects
  • Publications
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Our reseach group is composed of PhDs, PhD students and technicians. We are focused on the description and understanding how food bioactives modulate metabolism and health through enterendocrine signals, and their effects on appetite and anti-inflammatory activity, working mainly at the gastrointestinal tract level.

  • Study of signaling mechanisms in endocrine and inflammatory cells.
  • Bioactivity of food in cultured cell lines and historic systems that mimic the gastrointestinal barrier (enterocyte and hepatocyte co-culture systems, beta cells and endothelial cells).
  • Gastrointestinal wall functioning studies: Using Chambers, ex vivo systems.
  • Toxicity tests of dietary components.
  • Work on animal models (rat) of obesity, diabetes and inflammation. Molecular-level studies using enzymatic activity assays, gene expression (qPCR), protein expression and quantification (ELISA and immunoblotting), and Omic techniques.

  • 2017-2019: 2017 SGR 289. Molecular Bioactivity of Food. Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR).

  • 2018-2021: Preventive long-lasting effects of food bioactives on gastrointestinal tract under metabolic homeostatic challenges: obesogenic diet and aging. AGL2017-83477-R. MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD

  • Envejecimineto Saludable y Sostenible amb Proteïna de Insecto (ESSARPI) Funding entity: Diputación de Tarragona Duration:  2020 – 2021 Principal Investigator: Maria Teresa Blay Olivé


    Modulation of Food Intake by Differential TAS2R Stimulation in Rat

    Grau-Bové C, Miguéns-Gómez A, Gonzalez-Quilen, C, Fernández-López JA, Remesar X, Torres-Fuentes C, Ávila-Román J, Rodríguez-Gallego E, Beltrán-Debón R, Blay M, Terra X, Ardévol A, Pinent M. Nutrients. 2020;12(12):E3784. PMID: 33260866 Free article


    Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term.

    Grau-Bové C, Sierra-Cruz M, Miguéns-Gómez A, Rodríguez-Gallego E, Beltrán-Debón R, Blay M, Terra X, Pinent M, Ardévol A. Nutrients. 2020 Nov 27;12(12):E3647. PMID: 33260866 Free article.

    doi: 10.3390/nu12123647.

    Gastrointestinally Digested Protein from the Insect Alphitobius diaperinus Stimulates a Different Intestinal Secretome than Beef or Almond, Producing a Differential Response in Food Intake in Rats.

    Miguéns-Gómez A, Grau-Bové C, Sierra-Cruz M, Jorba-Martín R, Caro A, Rodríguez-Gallego E, Beltrán-Debón R, Blay MT, Terra X, Ardévol A, Pinent M. Nutrients. 2020 Aug 7;12(8):2366. PMID: 32784756 Free PMC article.

    doi: 10.3390/nu12082366.

    Long Term Exposure to a Grape Seed Proanthocyanidin Extract Enhances L-Cell Differentiation in Intestinal Organoids.

    Casanova-Marti, A.; Gonzalez-Abuin, N.; Serrano, J.; Blay, M. Teresa; Terra, X.; Frost, G.; Pinent, M.; Ardevol, A.
    Molecular nutrition & food research Pages: ‏e2000303 Published: 2020-Jul-01 (Epub 2020 Jul 01)

    DOI: 10.1002/mnfr.202000303

    Effects of Flavanols on Enteroendocrine Secretion.

    Grau-Bove, C.; Gonzalez-Quilen, C.; Terra, X.; Blay, M Teresa; Beltran-Debon, R.; Jorba-Martin, R.; Espina, B.; Pinent, M.; Ardevol, A. Biomolecules Volume: ‏ 10 Issue: ‏ 6 Published: ‏ 2020 Jun 01

    DOI: 10.3390/biom10060844

    Protective properties of grape-seed proanthocyanidins in human ex vivo acute colonic dysfunction induced by dextran sodium sulfate

    Gonzalez-Quilen, C; Grau-Bove, C; Jorba-Martin, R; Caro-Tarrago, A; Pinent, M; Ardevol, A; Beltran-Debon, R ; Terra, X; Blay, MT

    DOI: 10.1007/s00394-020-02222-3

    Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction.

    González-Quilen C, Rodríguez-Gallego E, Beltrán-Debón R, Pinent M, Ardévol A, Blay MT, Terra X.
    Nutrients. 2020 Jan 2;12(1). pii: E130.

    DOI: 10.3390/nu12010130 Review.

    Long-Lasting Effects of GSPE on Ileal GLP-1R Gene Expression Are Associated with a Hypomethylation of the GLP-1R Promoter in Female Wistar Rats

    Ginés I, Gil-Cardoso K, D’Addario C, Falconi A, Bellia F, Blay MT, Terra X, Ardévol A, Pinent M, Beltrán-Debón R.
    Biomolecules. 2019 Dec 12;9(12). pii: E865.

    DOI: 10.3390/biom9120865

    Proanthocyanidins Limit Adipose Accrual Induced by a Cafeteria Diet, Several Weeks after the End of the Treatment

    Ginés I, Gil-Cardoso K, Serrano J, Casanova-Marti À, Lobato M, Terra X, Blay MT, Ardévol A, Pinent M
    Genes (Basel). 2019 Aug 8;10(8). pii: E598.

    DOI: 10.3390/genes10080598

    Mining large databases to find new leads with low similarity to known actives: application to find new DPP-IV inhibitors

    Ojeda-Montes MJ, Casanova-Martí À, Gimeno A, Tomás-Hernández S, Cereto-Massagué A, Wolber G, Beltrán-Debón R, Valls C, Mulero M, Pinent M, Pujadas G, Garcia-Vallvé S.

    Future Med Chem. 2019 Jun;11(12):1387-1401. Epub 2019 Jul 12.

    DOI: 10.4155/fmc-2018-0597

    Antihyperglycemic effect of a chicken feet hydrolysate via the incretin system: DPP-IV-inhibitory activity and GLP-1 release stimulation

    Casanova-Martí À, Bravo FI, Serrano J, Ardévol A, Pinent M, Muguerza B.
    Food Funct. 2019 Jun 21.

    DOI: 10.1039/c9fo00695h [Epub ahead of print]

    Grape-Seed Proanthocyanidins are Able to Reverse Intestinal Dysfunction and Metabolic Endotoxemia Induced by a Cafeteria Diet in Wistar Rats

    González-Quilen C, Gil-Cardoso K, Ginés I, Beltrán-Debón R, Pinent M, Ardévol A, Terra X, Blay MT.
    Nutrients. 2019 Apr 29;11(5). pii: E979.

    DOI: 10.3390/nu11050979

    Grape Seed Proanthocyanidins Target the Enteroendocrine System in Cafeteria-Diet-Fed Rats

    Ginés I, Gil-Cardoso K, Terra X, Blay M, Pérez-Vendrell AM, Pinent M, Ardévol A.
    Mol Nutr Food Res. 2019 Apr 12:e1800912. [Epub ahead of print]

    DOI: 10.1002/mnfr.201800912

    Protective Effect of Proanthocyanidins in a Rat Model of Mild Intestinal Inflammation and Impaired Intestinal Permeability Induced by LPS

    Gil-Cardoso K, Comitato R, Ginés I, Ardévol A, Pinent M, Virgili F, Terra X, Blay M. Mol Nutr Food Res. 2019 Jan 17:e1800720. [Epub ahead of print]

    DOI: 10.1002/mnfr.201800720 

    The co-administration of proanthocyanidins and an obesogenic diet prevents the increase in intestinal permeability and metabolic endotoxemia derived to the diet.

    Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Blay M, Terra X.
    J Nutr Biochem. 2018 Dec;62:35-42. Epub 2018 Aug 30

    DOI: 10.1016/j.jnutbio.2018.07.012 

    A novel ex vivo experimental setup to investigate how food components stimulate the enteroendocrine secretions of different intestinal segments

    Ginés I, Gil-Cardoso K, Robles P, Arola L, Terra X, Blay M, Ardévol A, Pinent M.
    J Agric Food Chem. 2018 Aug 27. [Epub ahead of print]

    DOI: 10.1021/acs.jafc.8b03046.

    Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis

    Olona A, Terra X, Ko JH, Grau-Bové C, Pinent M, Ardevol A, Diaz AG, Moreno-Moral A, Edin M, Bishop-Bailey D, Zeldin DC, Aitman TJ, Petretto E, Blay M, Behmoaras J. Mol Metab. 2018 May;11:18-32. Epub 2018 Mar 9

    DOI: 10.1016/j.molmet.2018.03.003.

    Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rat

    Ginés I, Gil-Cardoso K, Serrano J, Casanova-Martí À, Blay MT, Pinent M, Ardévol A, Terra X
    Nutrients 2018, 10(3), 315;

    DOI: 10.3390/nu10030315 (registering DOI)

    Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female rats

    Casanova-Martí À, Serrano J, Portune KJ, Sanz Y, Blay MT, Terra X, Ardévol A, Pinent M.
    Food Funct. 2018 Feb 23. [Epub ahead of print]

    DOI: 10.1039/c7fo02028g.

Team Members

  • Group leader

    • Dra. Montse Pinent Grau
  • Senior researcher

    • Esther Rodríguez Gallego
    • Raúl Beltran Debón
    • Ximena Terra Barbadora
    • Anna Ardévol
    • Maria Teresa Blay Olivé