Succinate as a biomarker for selecting a bariatric surgical procedure and for predictin type 2 diabetis remission after bariatric surgery

MÉS INFORMACIÓ

Dades d'interès

  • Technology Readiness Level

    Current development status

  • Desired business relationship

    Looking for a partner interested in a license and/or a collaboration agreement to develop and exploit this asset.

  • Inventors

    Fernández Veledo, Sonia; Serena Perelló, Carolina; Vendrell Ortega, Joan Josep; Ceperuelo Mallafré, Victoria; Calvo Manso, Enrique

  • Priority Date

    02.07.2019

  • International Application No.

    EP19382564.3
    PCT/EP2020/068219

  • Contact

    isabel.huber@iispv.cat

Succinate as a biomarker for selecting a bariatric surgical procedure and for predictin type 2 diabetis remission after bariatric surgery

Abstract:

Bariatric surgery has emerged as an effective treatment for obesity, but there is limited evidence regarding the optimal candidate for each surgical procedure and remission rates of type 2 diabetes observed across published series vary. New tools are needed to better predict diabetes remission according to the surgical procedures in order to avoid unnecessarily aggressive surgeries and improve health outcomes.

  • Innovative Aspects

    The main innovate aspect of the method is that it is based on a single circulating metabolite that can be easily measured in blood. It is a single measurement that can be used independently of previously described pre-surgical factors and improves the current available scores to guide the decision on the type of bariatric surgery to achieve type 2 diabetes remission.

  • The Solution

    The technology DiaSuc provides a method for selecting a bariatric surgical procedure for a patient, as well as an informative biomarker for predicting, before bariatric surgery, type 2 diabetes remission after bariatric surgery in a patient suffering from type 2 diabetes.

  • Stage of Development

    The method has been described in a cohort of 45 subjects and confirmed in an independent validation cohort of 88 patients from a different centre.

  • Keywords

    Surgery, Medical Health related, Diagnostic, Therapeutic, Other therapeutic (including defibrillators), Clinical Medicine, Surgery and Anaesthesiology, obesity, bariàtric, non-invasive, diabetes