Unitat de nutrició humana: Prevenció i Epigenètica

NUTRICIÓ I METABOLISME
OBJECTIUS

El grup ha participat activament en la investigació dels efectes beneficiosos de la dieta mediterrània sobre les MCV. En els últims quinze anys, l’equip d’investigació ha portat a terme l’estudi PREDIMED, i l’estudi PREDIMED-PLUS, dos assajos clínics de prevenció primària de la MCV en més de 8000 participants en cada un d’ells. PREDIMED-Plus es coordinat pel nostre grup de recerca i hi participen 30 centres d’investigació d’arreu de l’Estat.
En els últims anys hem participat en diferents projectes Europeus en relació a la nutrició, la obesitat i la diabetis entre els que destaquen DEPLAN-CAT, SATIN, EAT2BENICE, STOP i PRIME. També hem estat co-investigadors principals de 2 projectes de metabolòmica del NIH dels EEUU en relació a la diabetis i MCVs, així com 2 projectes competitius internacionals en relació als fruits secs.
Més enllà de l’experiència en la supervisió de l’assessorament dels pacients, preparació i manteniment de bases de dades i estadístiques avançades, el grup ha adquirit experiència contrastada en el cam de les ómiques: metabolòmica, metagenòmica i transcriptòmica.

RESPONSABLES
  • Jordi SALAS-SALVADÓ

  • Línies
  • Membres del grup
  • Transferència
  • Publicació
  • Contactar
  • Dieta mediterrània i malaltia cardiovascular
  • Epidemiologia i salut pública en relació a la nutrició o les malalties de la nutrició.
  • Estudis d’intervenció per a conèixer l’efecte de la dieta o dels constituents de la dieta sobre la salut o la malaltia i els mecanismes Implicats.
  • Estudio de la relació entre l’obesitat, la inflamació i les diferents comorbilitats associades a l’obesitat.
  • Identificació de nous biomarcadors per a identificar estratègies de prevenció primària i secundària de malalties cròniques (obesitat, diabetis, malaltia cardiovascular).

  • Título: Cuestionario de valoración de regristro de bebidas

    Referència: I Depot 109483

    Autors: Salas Salvadó, Jordi;  Babio Sánchez, Nancy;  Serra-Majem, Luís;  Nissensohn, Mariela

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  • Julibert A, Bibiloni MDM, Bouzas C, Martínez-González MÁ, Salas-Salvadó J,Corella D, Zomeño MD, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J,Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X,Lopez-Miranda J, García-Molina L, Gaforio JJ, Matía-Martín P, Daimiel L,Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Toledo E, Becerra-Tomás N, Pórtoles O, Pérez-Vega KA, Fiol M, Torres-Collado L, Tojal-Sierra L, Carabaño-Moral R,Abete I, Sanchez-Villegas A, Casas R, Bernal-López MR, Santos-Lozano JM, GaleraA, Ugarriza L, Ruiz-Canela M, Babio N, Coltell O, Schröder H, Konieczna J,Orozco-Beltrán D, Sorto-Sánchez C, Eguaras S, Barrubés L, Fitó M, Tur JA;Predimed-Plus Investigators. Total and Subtypes of Dietary Fat Intake and ItsAssociation with Components of the Metabolic Syndrome in a MediterraneanPopulation at High Cardiovascular Risk. Nutrients. 2019 Jun 29;11(7). pii: E1493.doi: 10.3390/nu11071493. .PubMed PMID: 31261967; .PubMed Central PMCID: PMC6682917

  • Salas-Huetos A, Muralidharan J, Galiè S, Salas-Salvadó J, Bulló M. Effect of Nut Consumption on Erectile and Sexual Function in Healthy Males: A SecondaryOutcome Analysis of the FERTINUTS Randomized Controlled Trial. Nutrients. 2019Jun 19;11(6). pii: E1372. doi: 10.3390/nu11061372. .PubMed PMID: 31248067; .PubMed Central PMCID: PMC6627592

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  • Martínez-González MA, Buil-Cosiales P, Corella D, Bulló M, Fitó M, Vioque J, Romaguera D, Martínez JA, Wärnberg J, López-Miranda J, Estruch R,Bueno-Cavanillas A, Arós F, Tur JA, Tinahones F, Serra-Majem L, Martín V, LapetraJ, Vázquez C, Pintó X, Vidal J, Daimiel L, Delgado-Rodríguez M, Matía P, Ros E,Fernández-Aranda F, Botella C, Portillo MP, Lamuela-Raventós RM, Marcos A, SáezG, Gómez-Gracia E, Ruiz-Canela M, Toledo E, Alvarez-Alvarez I, Díez-Espino J,Sorlí JV, Basora J, Castañer O, Schröder H, Navarrete-Muñoz EM, Zulet MA,García-Rios A, Salas-Salvadó J; PREDIMED-Plus Study Investigators. CohortProfile: Design and methods of the PREDIMED-Plus randomized trial. Int JEpidemiol. 2019 Apr 1;48(2):387-388o. doi: 10.1093/ije/dyy225. .PubMed PMID:30476123

  • Guasch-Ferré M, Ruiz-Canela M, Li J, Zheng Y, Bulló M, Wang DD, Toledo E,Clish C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Lapetra J,Serra-Majem L, Liang L, Papandreou C, Dennis C, Martínez-González MA, Hu FB,Salas-Salvadó J. Plasma Acylcarnitines and Risk of Type 2 Diabetes in aMediterranean Population at High Cardiovascular Risk. J Clin Endocrinol Metab.2019 May 1;104(5):1508-1519. doi: 10.1210/jc.2018-01000. .PubMed PMID: 30423132;.PubMed Central PMCID: PMC6435097

  • Salas-Salvadó J, Díaz-López A, Ruiz-Canela M, Basora J, Fitó M, Corella D,Serra-Majem L, Wärnberg J, Romaguera D, Estruch R, Vidal J, Martínez JA, Arós F, Vázquez C, Ros E, Vioque J, López-Miranda J, Bueno-Cavanillas A, Tur JA,Tinahones FJ, Martín V, Lapetra J, Pintó X, Daimiel L, Delgado-Rodríguez M, MatíaP, Gómez-Gracia E, Díez-Espino J, Babio N, Castañer O, Sorlí JV, Fiol M, ZuletMÁ, Bulló M, Goday A, Martínez-González MÁ; PREDIMED-Plus investigators. Effectof a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet andExercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial. Diabetes Care. 2019 May;42(5):777-788. doi:10.2337/dc18-0836. Epub 2018 Nov 2. .PubMed PMID: 30389673

  • Álvarez-Álvarez I, Martínez-González MÁ, Sánchez-Tainta A, Corella D,Díaz-López A, Fitó M, Vioque J, Romaguera D, Martínez JA, Wärnberg J,López-Miranda J, Estruch R, Bueno-Cavanillas A, Arós F, Tur JA, Tinahones FJ,Serra-Majem L, Martín V, Lapetra J, Más Fontao S, Pintó X, Vidal J, Daimiel L,Gaforio JJ, Matía P, Ros E, Ruiz-Canela M, Sorlí JV, Becerra-Tomás N, Castañer O,Schröder H, Navarrete-Muñoz EM, Zulet MÁ, García-Ríos A, Salas-Salvadó J,Díez-Espino J, Toledo E. Adherence to an Energy-restricted Mediterranean DietScore and Prevalence of Cardiovascular Risk Factors in the PREDIMED-Plus: ACross-sectional Study. Rev Esp Cardiol (Engl Ed). 2019 Nov;72(11):925-934. doi:10.1016/j.rec.2018.08.010. Epub 2018 Oct 2. English, Spanish. .PubMed PMID:30287240

  • Yu E, Ruiz-Canela M, Razquin C, Guasch-Ferré M, Toledo E, Wang DD, PapandreouC, Dennis C, Clish C, Liang L, Bullo M, Corella D, Fitó M, Gutiérrez-Bedmar M,Lapetra J, Estruch R, Ros E, Cofán M, Arós F, Romaguera D, Serra-Majem L, SorlíJV, Salas-Salvadó J, Hu FB, Martínez-González MA. Changes in arginine areinversely associated with type 2 diabetes: A case-cohort study in the PREDIMEDtrial. Diabetes Obes Metab. 2019 Feb;21(2):397-401. doi: 10.1111/dom.13514. Epub 2018 Oct 2. .PubMed PMID: 30146690; .PubMed Central PMCID: PMC6329637

  • Konieczna J, Abete I, Galmés AM, Babio N, Colom A, Zulet MA, Estruch R, VidalJ, Toledo E, Díaz-López A, Fiol M, Casas R, Vera J, Buil-Cosiales P, Martín V,Goday A, Salas-Salvadó J, Martínez JA, Romaguera D; PREDIMED-Plus Investigators. Body adiposity indicators and cardiometabolic risk: Cross-sectional analysis inparticipants from the PREDIMED-Plus trial. Clin Nutr. 2019 Aug;38(4):1883-1891.doi: 10.1016/j.clnu.2018.07.005. Epub 2018 Jul 11. .PubMed PMID: 30031660

  • Viguiliouk E, Kendall CW, Kahleová H, Rahelić D, Salas-Salvadó J, Choo VL,Mejia SB, Stewart SE, Leiter LA, Jenkins DJ, Sievenpiper JL. Effect of vegetariandietary patterns on cardiometabolic risk factors in diabetes: A systematic reviewand meta-analysis of randomized controlled trials. Clin Nutr. 2019Jun;38(3):1133-1145. doi: 10.1016/j.clnu.2018.05.032. Epub 2018 Jun 13. .PubMedPMID: 29960809

  • Rosique-Esteban N, Babio N, Díaz-López A, Romaguera D, Alfredo Martínez J,Sanchez VM, Schröder H, Estruch R, Vidal J, Buil-Cosiales P, Konieczna J, AbeteI, Salas-Salvadó J. Leisure-time physical activity at moderate and high intensityis associated with parameters of body composition, muscle strength and sarcopeniain aged adults with obesity and metabolic syndrome from the PREDIMED-Plus study. Clin Nutr. 2019 Jun;38(3):1324-1331. doi: 10.1016/j.clnu.2018.05.023. Epub 2018Jun 6. .PubMed PMID: 29910068

  • Cárdenas-Fuentes G, Subirana I, Martinez-Gonzalez MA, Salas-Salvadó J,Corella D, Estruch R, Fíto M, Muñoz-Bravo C, Fiol M, Lapetra J, Aros F,Serra-Majem L, Tur JA, Pinto X, Ros E, Coltell O, Díaz-López A, Ruiz-Canela M,Schröder H. Multiple approaches to associations of physical activity andadherence to the Mediterranean diet with all-cause mortality in older adults: thePREvención con DIeta MEDiterránea study. Eur J Nutr. 2019 Jun;58(4):1569-1578.doi: 10.1007/s00394-018-1689-y. Epub 2018 Apr 25. .PubMed PMID: 29696401

  • Hernández-Alonso P, Giardina S, Cañueto D, Salas-Salvadó J, Cañellas N, BullóM. Changes in Plasma Metabolite Concentrations after a Low-Glycemic Index DietIntervention. Mol Nutr Food Res. 2019 Jan;63(1):e1700975. doi:10.1002/mnfr.201700975. Epub 2018 May 2. .PubMed PMID: 29603657

  • Camacho-Barcia L, Bulló M, García-Gavilán JF, Martínez-González MA, CorellaD, Estruch R, Fitó M, Gómez-Gracia E, Arós F, Fiol M, Santos-Lozano JM,Serra-Majem L, Pintó X, Basora J, Toledo E, Muñoz MA, Zanon-Moreno V,García-Layana A, Salas-Salvadó J. Dairy products intake and the risk of incident cataracts surgery in an elderly Mediterranean population: results from thePREDIMED study. Eur J Nutr. 2019 Mar;58(2):619-627. doi:10.1007/s00394-018-1647-8. Epub 2018 Mar 27. .PubMed PMID: 29589119

  • Papandreou C, Becerra-Tomás N, Bulló M, Martínez-González MÁ, Corella D,Estruch R, Ros E, Arós F, Schroder H, Fitó M, Serra-Majem L, Lapetra J, Fiol M,Ruiz-Canela M, Sorli JV, Salas-Salvadó J. Legume consumption and risk ofall-cause, cardiovascular, and cancer mortality in the PREDIMED study. Clin Nutr.2019 Feb;38(1):348-356. doi: 10.1016/j.clnu.2017.12.019. Epub 2018 Jan 9. .PubMed PMID: 29352655.

  • Mohammadifard N, Humphries KH, Gotay C, Mena-Sánchez G, Salas-Salvadó J,Esmaillzadeh A, Ignaszewski A, Sarrafzadegan N. Trace minerals intake: Risks and benefits for cardiovascular health. Crit Rev Food Sci Nutr. 2019;59(8):1334-1346.doi: 10.1080/10408398.2017.1406332. Epub 2017 Dec 13. Review. .PubMed PMID:29236516

Membres De L’equip

  • Responsable de grup

    • Jordi SALAS-SALVADÓ
  • Investigador senior

    • Silvia CANUDAS PUIG
    • Joan FERNÁNDEZ-BALLART
    • Nancy BABIO SÁNCHEZ
    • Michelle MURPHY
    • Marta Guasch Ferre
  • Investigador/a Post-doctoral

    • Pablo HERNÁNDEZ ALONSO
    • Nerea BECERRA-TOMÁS
    • Anna TRESSERRA-RIMBAU
    • Andrés DÍAZ LÓPEZ
  • Assistencial

    • Samira SHIG
    • Núria GUILLEN REY
    • Antoni RABASSA SOLER
    • Antoni PALAU GALINDO
    • Anna BONADA SANTJAUME
  • Doctorant

    • Tany Elisabeth GARCIDUEÑAS FIMBRES
    • Serena GALIÈ
    • Lucia Camacho-Barcia
    • Leyre LÓPEZ GONZÁLEZ
    • Laura BARRUBÉS PIÑOL
    • Júlia HARO BARCELÓ
    • Jesús F GARCÍA-GAVILÁN
    • Jananee Muralidharan
    • Indira PAZ GRANIEL
    • Carlos GÓMEZ MARTINEZ
    • Carla Ramos Rodríguez
    • Anna GILS CONTRERAS
    • Alessandro ATZENI
    • Alejandra ROJAS GÓMEZ
  • Tècnic/a

    • Sonia MANZANEDO VILA
    • Marianne Mendoza Herrera
    • Júlia ROIG VALLVERDÚ
    • Clàudia MIÑANA GARCIA
  • Administratiu/va

    • Susana SEGURA BENIGNO
    • Carles MUNNÉ CUEVAS