Presentació dels Hospitals
Col·labora

Grup de Recerca en Neurociències Clíniques

NEUROCIÈNCIES I SALUT MENTAL
MALALTIES PSIQUIÀTRIQUES FACTORS GENÈTICS TRASTORN MENTAL DISCAPACITAT INTEL·LECTUAL MALALTIES NEUROMUSCULARS NEUROTRANSMISSIÓ I PLASTICITAT NEURONAL
OBJECTIUS

El grup de recerca en neurociències clíniques, Tarraco Grup de recerca en Neurociències clíniques, treballa en el camp de les malalties neurològiques, incloent les malalties neurovasculars, les neuroinflamatòries i les neurodegeneratives. Els objectius del grup de recerca són:

Estudiar les diferents malalties que afecten al sistema nerviós.

Col·laborar en projectes que aportin valor al diagnòstic, pronòstic i prevenció de les malalties neurològiques.

Fer divulgació científica de les patologies que afecten el sistema nerviós dins del nostre territori.

RESPONSABLES

  • Dr. Xavier Ustrell

  • Línies de recerca
  • Membres del grup
  • Projectes
  • Publicacions
  • Difusió
  • Contacte
  • Malalties neurovasculars, el grup treballa en diferents projectes clínics per estudiar el diagnòstic, pronòstic i maneig agut dels pacients amb ictus isquèmics o hemorràgics, biomarcadors de la malaltia, ateromatosi i predictors clínics de fibril·lació auricular.
  • Neuroimmunologia. El grup de recerca col·labora en la xarxa catalana de l’esclerosi múltiple, així com en assajos clínics internacionals.
  • Malalties neurodegeneratives. Aquesta línia està centrada en la recerca de biomarcadors predictius de la malaltia d’Alzheimer així com en l’estudi de neuroimatges en diferents patologies neurodegeneratives.
  • Epilèpsia i malalties neuromusculars.

    On-going

  • A Multi-center, Randomized, open-label blinded endpoint (PROBE), phase III study, for the comparation of Tenecteplase (TNK) versus Alteplase, with a 1:1 allocation, before thrombectomy in patients with acute ischemic stroke and large vessel occlusion in Catalonia (TNK-CAT). Principal Investigator: Dr. Xavier Ustrell. Hospital Joan XXIII Tarragona-IISPV. Sponsor: Vall d’Hebrón Institut de Recerca (VHIR). Principal Investigator. Ongoing. NCT05626972

  • “A randomized trial on hemodynamic optimization of cerebral perfusion after endovascular therapy in patients with acute ischemic stroke”. Principal Investigator: Dr. Alan Flores. Hospital Joan XXIII Tarragona-IISPV. Sponsor: Hospital Sant Pau Barcelona. CoInvestigator. Ongoing. NCT04892511

  • ENRICH-AF. “Edoxaban for Intracranial hemorrhage survivors with Atrial Fibrillation”. Principal Investigator: Dr. Xavier Ustrell. Hospital Joan XXIII Tarragona IISPV. Sponsor: Population Health Research Institute Canada. Ongoing. NCT03950076

  • OCEANIC-STROKE. A Study to Learn More About Asundexian (Also Called BAY2433334) for Prevention of Ischemic Stroke in Male and Female Participants Aged 18 Years and Older Who Already Had Such a Stroke Due to a Blood Clot That Formed Outside the Heart and Travelled to the Brain, or Temporary Stroke-like Symptoms. Hospital Joan XXIII Tarragona IISPV. Sponsor: Bayer Pharmaceuticals. 2023. Principal Investigator Dr. Xavier Ustrell. Clinical Research Coordinator. Ongoing. NCT05686070

  • LIBREXIA-STROKE. A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE. Principal Investigator: Dr. Xavier Ustrell. Hospital Joan XXIII Tarragona IISPV. Sponsor: Jansen Pharmaceuticals. Clinical Research Coordinator. Ongoing. NCT05702034.

  • “Manejo de los lípidos en pacientes con Ictus en Cataluña y Baleares”. Principal Investigator: Dr. Alan Flores. Hospital Joan XXIII Tarragona IISPV. Co-Investigator. Ongoing.

  • HIC-CAT. Beneficios del Ingreso Precoz en un centro Terciario para Pacientes con Hemorragia Intracerebral. Sponsor: Hospital de la Santa Creu i Sant Pau. Acting as: Co-Investigator. Hospital Joan XXIII Tarragona-IISPV. Ongoing.

  • CONVINCE . “Colchicine for Prevention of Vascular Inflammation in Non-Cardioembolic Stroke. Prospective Randomised Open-label Blinded Endpoint Clinical Trial of Low-dose Colchicine for Secondary Prevention After Stroke”. Principal Investigator Dr.Xavier Ustrell. Hospital Joan XXIII Tarragona-IISPV. Sponsor: Health Research Board Stroke Clinical Trial Network Ireland. 2018. Principal Investigator. Ongoing. NCT02898610

     

    Complerts

  • AXIOMATIC –SSP Trial. Antithrombotic Treatment with Factor Xia Inhibition to Optimize Management of Acute Thromboembolic Events in Secondary Stroke Prevention. Principal Investigator: Dr. Xavier Ustrell. Hospital Universitari Joan XXIII Tarragona IISPV. Closed. Acting as Principal Investigator. NCT03766581

  • “A Trial Comparing Transfer to the Closest Local Stroke Center vs Direct Transfer to Endovascular Stroke Center of Acute Stroke Patients with Suspected Large Vessel Occlusion in the Catalan Territory”. Sponsor: Fundaciò Ictus Malaltia Vascular. 2019. Principal Investigator. Closed.
    Pérez de la Ossa N, Abilleira S, Jovin TG, et al. ; RACECAT Trial Investigators. Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial. JAMA. 2022 May 10;327(18):1782-1794. doi: 10.1001/jama.2022.4404. Erratum in: JAMA. 2023 Apr 4;329(13):1123. PMID: 35510397; PMCID: PMC9073661.

  • RESPECT-ESUS. Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source. Funded by Boehringer Ingelheim; RE-SPECT ESUS ClinicalTrials.gov number, NCT02239120. Closed.
    Diener HC, Sacco RL, Easton JD, et al.; RE-SPECT ESUS Steering Committee and Investigators. Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source. N Engl J Med. 2019 May 16;380(20):1906-1917. doi: 10.1056/NEJMoa1813959. PMID: 31091372.

  • WAKE UP stroke: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. Funded by the European Union Seventh Framework Program. WAKE-UP ClinicalTrials.gov number, NCT01525290; and EudraCT number, 2011-005906-32. Closed. Thomalla G, Simonsen CZ, Boutitie F et al. ; WAKE-UP Investigators. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med. 2018 Aug 16;379(7):611-622. doi: 10.1056/NEJMoa1804355. Epub 2018 May 16. PMID: 29766770.

  • ENOS Trial. “Efficacy of nítric oxide, with or without continuing antihypertensive treatment, for management of high Blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Universitat Notthingam”. 2014. NCT 00989716. Closed.
    ENOS Trial Investigators. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet. 2015 Feb 14;385(9968):617-628. doi: 10.1016/S0140-6736(14)61121-1. Epub 2014 Oct 21. Erratum in: Lancet. 2015 Feb 14;385(9968):606. PMID: 25465108; PMCID: PMC4343308.

    Año

    Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants.

    Meinel TR, Wilson D, Gensicke H, Scheitz JF, Ringleb P, Goganau I, Kaesmacher J, Bae HJ, Kim DY, Kermer P, Suzuki K, Kimura K, Macha K, Koga M, Wada S, Altersberger V, Salerno A, Palanikumar L, Zini A, Forlivesi S, Kellert L, Wischmann J, Kristoffersen ES, Beharry J, Barber PA, Hong JB, Cereda C, Schlemm E, Yakushiji Y, Poli S, Leker R, Romoli M, Zedde M, Curtze S, Ikenberg B, Uphaus T, Giannandrea D, Portela PC, Veltkamp R, Ranta A, Arnold M, Fischer U, Cha JK, Wu TY, Purrucker JC, Seiffge DJ; DOAC-IVT Writing Group for the International DOAC-IVT, TRISP, and CRCS-K-NIH Collaboration. JAMA Neurol. 2023 Jan 3;80(3):233–43. doi: 10.1001/jamaneurol.2022.4782. Epub ahead of print. Erratum in: JAMA Neurol. 2023 Apr 1;80(4):422. PMID: 36807495; PMCID: PMC9857462.

    Influence of vascular imaging acquisition at local stroke centers on workflows in the drip-n-ship model: a RACECAT post hoc analysis. J Neurointerv Surg.

    Flores A, Garcia-Tornel A, Seró L, Ustrell X, Requena M, Pellisé A, Rodriguez P, Monterde A, Lara L, Gonzalez-de-Echavarri JM, Molina CA, Doncel- Moriano A, Dorado L, Cardona P, Cánovas D, Krupinski J, Más N, Purroy F, Zaragoza-Brunet J, Palomeras E, Cocho D, Garcia J, Colom C, Silva Y, Gomez-Cocho M, Jiménez X, Ros-Roig J, Abilleira S, Pérez de la Ossa N, Ribo M; RACECAT trial investigators. 2023 Apr 17:jnis-2023-020125. doi: 10.1136/jnis-2023-020125. Epub ahead of print. PMID: 37068936.

    Reperfusion therapy in acute ischaemic stroke due to cervical and cerebral artery dissection: Results from a Spanish multicentre study. Neurologia (Engl Ed).

    Campo-Caballero D, de la Riva P, de Arce A, Martínez-Zabaleta M, Rodríguez- Antigüedad J, Ekiza J, Iruzubieta P, Purroy F, Fuentes B, de Lera Alfonso M, Krupinski J, Mengual Chirife JJ, Palomeras E, Guisado-Alonso D, Rodríguez-Yáñez M, Ustrell X, Tejada García J, de Felipe Mimbrera A, Paré-Curell M, Tembl J, Cajaraville S, Garcés M, Serena J. 2023 Jul-Aug;38(6):412-418. doi: 10.1016/j.nrleng.2020.10.012. Epub 2022 Jul 13. PMID: 35842129.

    Accuracy of a Smartwatch to Assess Heart Rate Monitoring and Atrial Fibrillation in Stroke Patients. Sensors (Basel).

    Meza C, Juega J, Francisco J, Santos A, Duran L, Rodriguez M, Alvarez-Sabin J, Sero L, Ustrell X, Bashir S, Serena J, Silva Y, Molina C, Pagola J. 2023 May 10;23(10):4632. doi: 10.3390/s23104632. PMID: 37430546.

    Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas.

    Garcia-Tornel A, Millan M, Rubiera M, Bustamante A, Requena M, Dorado L, Olivé-Gadea M, Jiménez X, Soto A, Querol M, Hernández-Pérez M, Gomis M, Cardona P, Urra X, Purroy F, Silva Y, Ustrell X, Esteve P, Salvat-Plana M, Gallofré M, Molina C, Dávalos A, Jovin T, Abilleira S, Ribo M, Pérez de la Ossa N; RACECAT Trial Investigators. Stroke. 2022 Dec;53(12):3728-3740. doi: 10.1161/STROKEAHA.122.040768. Epub 2022 Oct 19. PMID: 36259411.

    Catalan Stroke Code and Reperfusion Consortium. The Role of Vascular Imaging atReferral Centers in the Drip and Ship Paradigm. J Stroke Cerebrovasc Dis.

    Flores A, Seró L, Gomez-Choco M, Ustrell X, Pellisé A, Viñas J, Rodriguez P, Monterde A, Castilho G, Rubiera M, Amaro S, Padrós MAF, Cardona P, Marti- Fabregas J, Molina CA, Serena J, Jimenez-Fábrega FX, Purroy F, Zaragoza-Brunet J, Cocho D, Palomeras E, Kuprinski J, Más N, Hernández-Perez M, Sanjurjo E, Carrión D, Costa X, Barceló M, Monedero J, Catena E, Rybyeba M, Díaz G, de la Ossa NP, Ribó M;  2022 Jan;31(1):106209. doi: 10.1016/j.jstrokecerebrovasdis.2021.106209. Epub 2021 Nov 15. PMID: 34794029.

    Predictors of Functional Outcome After Thrombectomy in Patients With Prestroke Disability in Clinical Practice. Stroke.

    Millán M, Ramos-Pachón A, Dorado L, Bustamante A, Hernández-Pérez M, Rodríguez-Esparragoza L, Gomis M, Remollo S, Castaño C, Werner M, Wenger D, Rubio S, Domínguez-Lizarbe M, Terceño M, Paipa AJ, Rodríguez-Vázquez A, Boned S, Camps-Renom P, Cánovas D, Giralt E, López-Cancio E, Dávalos A, Ros-Roig J, Pérez de la Ossa N; Cat-SCR Consortium*. 2022 Mar;53(3):845-854. doi: 10.1161/STROKEAHA.121.034960. Epub 2021 Oct 27. PMID: 34702065.

    Determinants and Trends of the Use of Intravenous Thrombolysis for Minor Stroke: A Population-Based Study, 2016 to 2020. Stroke.

    Font MÀ, García-Sánchez SM, Mengual JJ, Mena L, Avellaneda C, Serena J, Valls-Carbó A, Chamorro Á, Ustrell X, Molina C, Cardona P, Guasch-Jiménez M, Purroy F, Rodríguez-Campello A, Palomeras E, Cocho D, Krupinski J, Cánovas D, García-Alhama J, Zaragoza J, Puiggròs E, Matos N, Aragonès JM, Costa X, Sanjurjo E, Pedroza C, Monedero J, Almendros MC, Rybyeva M, Carrión D, Díaz G, Barceló M, Jiménez-Fàbrega X, Salvat-Plana M, Elosúa R, Pérez de la Ossa N, Gómez-Choco M; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR Consortium). 2022 Nov;53(11):3289-3294. doi: 10.1161/STROKEAHA.122.038996. Epub 2022 Aug 10. PMID: 35946402.

    Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke.

    Ramiro L, Abraira L, Quintana M, García-Rodríguez P, Santamarina E, Álvarez- Sabín J, Zaragoza J, Hernández-Pérez M, Ustrell X, Lara B, Terceño M, Bustamante A, Montaner J. Life (Basel). 2021 Feb 10;11(2):135. doi: 10.3390/life11020135. PMID: 33578805; PMCID: PMC7916549.

    Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke.

    Martí-Fàbregas J, Guisado-Alonso D, Delgado-Mederos R, Martínez-Domeño A, Prats-Sánchez L, Guasch-Jiménez M, Cardona P, Núñez-Guillén A, Requena M, Rubiera M, Olivé M, Bustamante A, Gomis M, Amaro S, Llull L, Ustrell X, Castilho de Oliveira G, Seró L, Gomez-Choco M, Mena L, Serena J, Bashir Viturro S, Purroy F, Vicente M, Rodríguez-Campello A, Ois A, Catena E, Carmen Garcia-Carreira M, Barrachina O, Palomeras E, Krupinski J, Almeria M, Zaragoza J, Esteve P, Cocho D, Moreira A, van Eendenburg C, Emilio Codas J, Pérez de la Ossa N, Salvat M, Camps-Renom P; COVICTUS Collaborators. Stroke. 2021 Dec;52(12):3908-3917. doi: 10.1161/STROKEAHA.121.034883. Epub 2021 Aug 30. PMID: 34455823; PMCID: PMC8607902.

    D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke.

    Ramos-Pachón A, López-Cancio E, Bustamante A, Pérez de la Ossa N, Millán M, Hernández-Pérez M, Garcia-Berrocoso T, Cardona P, Rubiera M, Serena J, Ustrell X, Garcés M, Terceño M, Dávalos A, Montaner J. Stroke. 2021 Mar;52(3):852-858. doi: 10.1161/STROKEAHA.120.031657. Epub 2021 Feb 10. PMID: 33563016.

    Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia. Cerebrovasc Dis.

    Ramos-Pachón A, García-Tornel Á, Millán M, Ribó M, Amaro S, Cardona P, Martí-Fàbregas J, Roquer J, Silva Y, Ustrell X, Purroy F, Gómez-Choco M, Zaragoza-Brunet J, Cánovas D, Krupinski J, Sala NM, Palomeras E, Cocho D, Redondo L, Repullo C, Sanjurjo E, Carrión D, López M, Almendros MC, Barceló M, Monedero J, Catena E, Rybyeba M, Diaz G, Jiménez-Fàbrega X, Solà S, Hidalgo V, Pueyo MJ, Pérez de la Ossa N, Urra X; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR).  2021;50(5):551-559. doi: 10.1159/000516309. Epub 2021 May 21. PMID: 34023822; PMCID: PMC8247826.

    Reasons for Not Performing Mechanical Thrombectomy: A Population-Based Study of Stroke Codes. Stroke.

    Guisado-Alonso D, Martínez-Domeño A, Prats-Sánchez L, Delgado-Mederos R, Camps-Renom P, Abilleira S, de la Ossa NP, Ramos-Pachón A, Cardona P, Rodríguez- Campello A, Molina CA, Rudilosso S, Martí-Fàbregas J; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). 2021 Aug;52(9):2746-2753. doi: 10.1161/STROKEAHA.120.032648. Epub 2021 Jul 22. PMID: 34289711.

    Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population- Based Registry.

    Rudilosso S, Ríos J, Rodríguez A, Gomis M, Vera V, Gómez-Choco M, Renú A, Matos N, Llull L, Purroy F, Amaro S, Terceño M, Obach V, Serena J, Martí- Fàbregas J, Cardona P, Molina C, Rodríguez-Campello A, Cánovas D, Krupinski J, Ustrell X, Torres F, Román LS, Salvat-Plana M, Jiménez-Fàbrega FX, Palomeras E, Catena E, Colom C, Cocho D, Baiges J, Aragones JM, Diaz G, Costa X, Almendros MC, Rybyeba M, Barceló M, Carrión D, Lòpez MN, Sanjurjo E, de la Ossa NP, Urra X, Chamorro Á; Catalan Stroke Code and Reperfusion (Cat-SCR) Consortium. Effectiveness of Thrombectomy in Stroke According to Baseline Prognostic Factors: Inverse Probability of Treatment Weighting Analysis of a Population- Based Registry. J Stroke. 2021 Sep;23(3):401-410. doi: 10.5853/jos.2021.00962. Epub 2021 Sep 30. PMID: 34649384; PMCID: PMC8521260.

    Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet.

    Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O, Bendszus M, Bladin CF, Campbell BCV, Cheng B, Churilov L, Ebinger M, Endres M, Fiebach JB, Fukuda-Doi M, Inoue M, Kleinig TJ, Latour LL, Lemmens R, Levi CR, Leys D, Miwa K, Molina CA, Muir KW, Nighoghossian N, Parsons MW, Pedraza S, Schellinger PD, Schwab S, Simonsen CZ, Song SS, Thijs V, Toni D, Hsu CY, Wahlgren N, Yamamoto H, Yassi N, Yoshimura S, Warach S, Hacke W, Toyoda K, Donnan GA, Davis SM, Gerloff C;  2020 Nov 14;396(10262):1574-1584. doi: 10.1016/S0140-6736(20)32163-2. Epub 2020 Nov 8. PMID: 33176180; PMCID: PMC7734592.

    Blood biomarkers predictive of epilepsy after an acute stroke event. Epilepsia.

    Abraira L, Santamarina E, Cazorla S, Bustamante A, Quintana M, Toledo M, Fonseca E, Grau-López L, Jiménez M, Ciurans J, Luis Becerra J, Millán M, Hernández-Pérez M, Cardona P, Terceño M, Zaragoza J, Cánovas D, Gasull T, Ustrell X, Rubiera M, Castellanos M, Montaner J, Álvarez-Sabín J. 2020 Oct;61(10):2244-2253. doi: 10.1111/epi.16648. Epub 2020 Aug 28. PMID: 32857458.

    Correlation of blood biomarkers with early-onset seizures after an acute stroke event. Epilepsy Behav.

    Abraira L, Giannini N, Santamarina E, Cazorla S, Bustamante A, Quintana M, Toledo M, Grau-López L, Jiménez M, Ciurans J, Becerra JL, Millán M, Cardona P, Terceño M, Zaragoza J, Cánovas D, Gasull T, Ustrell X, Rubiera M, Castellanos M, Dávalos A, Montaner J, Álvarez-Sabin J. 2020 Mar;104(Pt B):106549. doi: 10.1016/j.yebeh.2019.106549. Epub 2019 Oct 31. Erratum in: Epilepsy Behav. 2020 May;106:107045. PMID: 31677998.

    Vascular Occlusion Evolution in Endovascular Reperfusion Candidates Transferred from Primary to Comprehensive Stroke Centers. Cerebrovasc Dis.

    Flores A, Ustrell X, Seró L, Pellisé A, Rodriguez P, Viñas J, Ribó M, Krupinski J, Más N, Garcia S, Palomeras Soler E, Cocho D, Canovas D, Purroy F, Serena J, Zaragoza-Brunet J, Obach V, Perez de la Ossa N, Cardona P, Molina CA, Abilleira S, Rubiera M; Catalan Stroke Code and Reperfusion Consortium. 2020;49(5):550-555. doi: 10.1159/000511063. Epub 2020 Oct 22. PMID: 33091908.

    Clinical and neuroimaging criteria to improve the workflow in transfers for endovascular treatment evaluation. Int J Stroke.

    Requena M, Olivé-Gadea M, Boned S, Ramos A, Cardona P, Urra X, Serena J, Silva Y, Purroy F, Ustrell X, Abilleira S, Tomasello A, Perez de la Ossa N, Molina CA, Ribo M, Rubiera M; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). 2020 Dec;15(9):988-994. doi: 10.1177/1747493019874725. Epub 2019 Sep 10. PMID: 31506026.

    Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial. Stroke.

    Cheng B, Boutitie F, Nickel A, Wouters A, Cho TH, Ebinger M, Endres M, Fiebach JB, Fiehler J, Galinovic I, Puig J, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G; WAKE-UP (Efficacy and Safety of MRI-Based Thrombolysis inWake-Up Stroke Trial) investigators and administrative staff are as follows:. 2020 Jan;51(1):209-215. doi: 10.1161/STROKEAHA.119.027390. Epub 2019 Oct 30. PMID: 31662118.

    Corrigendum to "Correlation of blood biomarkers with early-onset seizures after an acute stroke event" [Epilepsy Behav 104(Pt B) (2020 Mar)].

    Abraira L, Giannini N, Santamarina E, Cazorla S, Bustamante A, Quintana M, Toledo M, Grau-López L, Jiménez M, Ciurans J, Becerra JL, Millán M, Cardona P, Terceño M, Zaragoza J, Cánovas D, Gasull T, Ustrell X, Rubiera M, Castellanos M, Dávalos A, Montaner J, Álvarez-Sabin J. Epilepsy Behav. 2020 May;106:107045. doi: 10.1016/j.yebeh.2020.107045. Epub 2020 Apr 2. Erratum for: Epilepsy Behav. 2020 Mar;104(Pt B):106549. PMID: 32248061.

    Reperfusion treatment in acute ischaemic stroke due to cervical and cerebral artery dissection: results of a Spanish national multicentre study. Neurologia (Engl Ed).

    Campo-Caballero D, de la Riva P, de Arce A, Martínez-Zabaleta M, Rodríguez- Antigüedad J, Ekiza J, Iruzubieta P, Purroy F, Fuentes B, de Lera Alfonso M, Krupinski J, Mengual Chirife JJ, Palomeras E, Guisado-Alonso D, Rodríguez-Yáñez M, Ustrell X, Tejada García J, de Felipe Mimbrera A, Paré-Curell M, Tembl J, Cajaraville S, Garcés M, Serena J. 2020 Dec 21:S0213-4853(20)30430-8. English, Spanish. doi: 10.1016/j.nrl.2020.10.016. Epub ahead of print. PMID: 33358059.

    Safety and efficacy of intravenous thrombolysis in stroke patients on prior antiplatelet therapy in the WAKE-UP trial. Neurol Res Pract.

    Frey BM, Boutitie F, Cheng B, Cho TH, Ebinger M, Endres M, Fiebach JB, Fiehler J, Ford I, Galinovic I, Königsberg A, Puig J, Roy P, Wouters A, Magnus T, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G; WAKE-UP investigators. 2020 Nov 20;2:40. doi: 10.1186/s42466-020-00087-9. PMID: 33324940; PMCID: PMC7678217.

    Vascular Occlusion Evolution in Endovascular Reperfusion Candidates Transferred from Primary to Comprehensive Stroke Centers.

    Flores A, Ustrell X, Seró L, Pellisé A, Rodriguez P, Viñas J, Ribó M, Krupinski J, Más N, Garcia S, Palomeras Soler E, Cocho D, Canovas D, Purroy F, Serena J, Zaragoza-Brunet J, Obach V, Perez de la Ossa N, Cardona P, Molina CA, Abilleira S, Rubiera M; Catalan Stroke Code and Reperfusion Consortium. Cerebrovasc Dis. 2020;49(5):550-555. doi: 10.1159/000511063.

    Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.

    Diener HC, Sacco RL, Easton JD, Granger CB, Bernstein RA, Uchiyama S, Kreuzer J, Cronin L, Cotton D, Grauer C, Brueckmann M, Chernyatina M, Donnan G, Ferro JM, Grond M, Kallmünzer B, Krupinski J, Lee BC, Lemmens R, Masjuan J, Odinak M, Saver JL, Schellinger PD, Toni D, Toyoda K; RE-SPECT ESUS Steering Committee and Investigators. Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source. N Engl J Med. 2019 May 16;380(20):1906-1917. doi: 10.1056/NEJMoa1813959. PMID: 31091372.

    Age- and Sex-Specific Risk Profiles and In-Hospital Mortality in 13,932 Spanish Stroke Patients. Cerebrovasc Dis.

    Purroy F, Vena A, Forné C, de Arce AM, Dávalos A, Fuentes B, Arenillas JF, Krupinski J, Gómez-Choco M, Palomeras E, Martí-Fábregas J, Castillo J, Ustrell X, Tejada J, Masjuan J, Garcés M, Benabdelhak I, Serena J. 2019;47(3-4):151-164. doi: 10.1159/000500205. Epub 2019 May 3. PMID: 31055571.

    Pre-Existing Cerebral Small Vessel Disease Limits Early Recovery in Patients with Acute Lacunar Infarct. J Stroke Cerebrovasc Dis.

    Gómez-Choco M, Mengual JJ, Rodríguez-Antigüedad J, Paré-Curell M, Purroy F, Palomeras E, Fuentes B, Ustrell X, Tembl J, Rodríguez-Yañez M, Castellanos M, Martí-Fabregas J, Serena J. 2019 Nov;28(11):104312. doi: 10.1016/j.jstrokecerebrovasdis.2019.104312. Epub 2019 Aug 5. PMID: 31395422.

    Revalidation of the RACE scale after its regional implementation in Catalonia: a triage tool for large vessel occlusion.

    Carrera D, Gorchs M, Querol M, Abilleira S, Ribó M, Millán M, Ramos A, Cardona P, Urra X, Rodríguez-Campello A, Prats-Sánchez L, Purroy F, Serena J, Cánovas D, Zaragoza-Brunet J, Krupinski JA, Ustrell X, Saura J, García S, Mora MÀ, Jiménez X, Dávalos A, Pérez de la Ossa N; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). J Neurointerv Surg. 2019 Aug;11(8):751-756. doi: 10.1136/neurintsurg-2018-014519. Epub 2018 Dec 22. PMID: 30580284.

    MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset.

    Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, Cheripelli B, Cho TH, Fazekas F, Fiehler J, Ford I, Galinovic I, Gellissen S, Golsari A, Gregori J, Günther M, Guibernau J, Häusler KG, Hennerici M, Kemmling A, Marstrand J, Modrau B, Neeb L, Perez de la Ossa N, Puig J, Ringleb P, Roy P, Scheel E, Schonewille W, Serena J, Sunaert S, Villringer K, Wouters A, Thijs V, Ebinger M, Endres M, Fiebach JB, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Gerloff C; WAKE-UP Investigators.  N Engl J Med. 2018 Aug 16;379(7):611-622. doi: 10.1056/NEJMoa1804355. Epub 2018 May 16. PMID: 29766770.

    Factors associated with poor anticoagulation control with vitaminK antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study. Rev Clin Esp (Barc).

    Contreras Muruaga MM, Reig G, Vivancos J, González A, Cardona P, Ramírez- Moreno JM, Martí-Fábregas J, Suárez Fernández C; en nombre de los investigadores del estudio ALADIN; Listado de investigadores del estudio ALADIN. 2018 Oct;218(7):327-335. English, Spanish. doi: 10.1016/j.rce.2018.04.020. Epub 2018 Jul 6. PMID: 29983190.

    Some light in the shadows of atrial fibrillation and stroke: To look or not to look. Neurology.

    Ustrell X, Tagawa M. 2017 Oct 10;89(15):1536-1537. doi: 10.1212/WNL.0000000000004504. Epub 2017 Sep 13. PMID: 28904089.

    Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study. Stroke.

    Bustamante A, López-Cancio E, Pich S, Penalba A, Giralt D, García-Berrocoso T, Ferrer-Costa C, Gasull T, Hernández-Pérez M, Millan M, Rubiera M, Cardona P, Cano L, Quesada H, Terceño M, Silva Y, Castellanos M, Garces M, Reverté S, Ustrell X, Marés R, Baiges JJ, Serena J, Rubio F, Salas E, Dávalos A, Montaner J. 2017 Sep;48(9):2419-2425. doi: 10.1161/STROKEAHA.117.017076. Epub 2017 Jul 17. PMID: 28716979.

    Outcomes After Direct Thrombectomy or Combined Intravenous and Endovascular Treatment Are Not Different. Stroke.

    Abilleira S, Ribera A, Cardona P, Rubiera M, López-Cancio E, Amaro S, Rodríguez-Campello A, Camps-Renom P, Cánovas D, de Miquel MA, Tomasello A, Remollo S, López-Rueda A, Vivas E, Perendreu J, Gallofré M; Catalan Stroke Code and Reperfusion Consortium. 2017 Feb;48(2):375-378. doi: 10.1161/STROKEAHA.116.015857. Epub 2017 Jan 6. PMID: 28062859.

    Catalan Stroke Code and Reperfusion Consortium. Influence of Hospital Type on Outcomes of Individuals Aged 80 and Older with Stroke Treated Using Intravenous Thrombolysis. J Am Geriatr Soc.

    Purroy F, Vena A, Cánovas D, Cardona P, Cocho D, Cuadrado-Godia E, Chamorro A, Dávalos A, Garcés M, Gomis M, Krupinski J, Palomeras E, Ribó M, Roquer J, Rubiera M, Sanahuja J, Saura J, Serena J, Ustrell X, Vargas M, Benabdelhak I, Abilleira S, Gallofré M; 2017 Sep;65(9):E117-E122. doi: 10.1111/jgs.14935. Epub 2017 Jun 2. PMID: 28574595.

    Access to Endovascular Treatment in Remote Areas: Analysis of the Reperfusion Treatment Registry of Catalonia. Stroke.

    Pérez de la Ossa N, Abilleira S, Dorado L, Urra X, Ribó M, Cardona P, Giralt E, Martí-Fàbregas J, Purroy F, Serena J, Cánovas D, Garcés M, Krupinski J, Pellisé A, Saura J, Molina C, Dávalos A, Gallofré M; Catalan Stroke Code and Reperfusion Consortium. 2016 May;47(5):1381-4. doi: 10.1161/STROKEAHA.116.013069. Epub 2016 Mar 31. PMID: 27032445.

    Clinicopathological Correlations and Concomitant Pathologies in Rapidly Progressive Dementia: A Brain Bank Series. Neurodegener Dis.

    Grau-Rivera O, Gelpi E, Nos C, Gaig C, Ferrer I, Saiz A, Lladó A, Molinuevo JL, Graus F, Sánchez-Valle R; Neurological Tissue Bank Collaborative Group. 2015;15(6):350-60. doi: 10.1159/000439251. Epub 2015 Oct 31. PMID: 26523804.

    Mechanical Thrombectomy in and Outside the REVASCAT Trial: Insights From a Concurrent Population-Based Stroke Registry. Stroke.

    Urra X, Abilleira S, Dorado L, Ribó M, Cardona P, Millán M, Chamorro A, Molina C, Cobo E, Dávalos A, Jovin TG, Gallofré M; Catalan Stroke Code and Reperfusion Consortium. 2015 Dec;46(12):3437-42. doi: 10.1161/STROKEAHA.115.011050. Epub 2015 Oct 27. PMID: 26508752.

    Functional outcome after primary endovascular therapy or IV thrombolysis alone for stroke. An observational, comparative effectiveness study. Cerebrovasc Dis.

    Abilleira S, Ribera A, Dávalos A, Ribó M, Chamorro A, Cardona P, Molina CA, Martínez-Yélamos A, Urra X, Dorado L, Roquer J, Martí-Fàbregas J, Aja L, Tomasello A, Castaño C, Blasco J, Cánovas D, Castellanos M, Krupinski J, Guimaraens L, Perendreu J, Ustrell X, Purroy F, Gómez-Choco M, Baiges JJ, Cocho D, Saura J, Gallofré M; Catalan Stroke Code and Reperfusion Consortium. 2014;38(5):328-36. doi: 10.1159/000368433. Epub 2014 Nov 21. PMID: 25428822.

    Impacto de la fibrinólisis en el ictus isquémico sobre la mejoría clínica y la calidad de vida. Implementación del código ictus en el hospital de referencia del Camp de Tarragona [Impact of fibrinolysis in ischemic stroke upon clinical improvement and patient quality of life. Introduction of the stroke code in the reference hospital of Camp de Tarragona (Spain)]. Med Intensiva.

    Oliva I, Cos E, Sandiumenge A, Rosich S, Ustrell X, Rodriguez A.2014 Oct;38(7):468-70. Spanish. doi: 10.1016/j.medin.2013.11.005. Epub 2014 Aug 8. PMID: 25109835.

    Outcomes of a contemporary cohort of 536 consecutive patients with acute ischemic stroke treated with endovascular therapy. Stroke.

    Abilleira S, Cardona P, Ribó M, Millán M, Obach V, Roquer J, Cánovas D, Martí-Fàbregas J, Rubio F, Alvarez-Sabín J, Dávalos A, Chamorro A, de Miquel MA, Tomasello A, Castaño C, Macho JM, Ribera A, Gallofré M; Catalan Stroke Code and Reperfusion Consortium. 2014 Apr;45(4):1046-52. doi: 10.1161/STROKEAHA.113.003489. Epub 2014 Mar 4. PMID: 24595590.

    Medical and endovascular treatment of patients with large vessel occlusion presenting with mild symptoms: an observational multicenter study. Cerebrovasc Dis.

    Urra X, San Román L, Gil F, Millán M, Cánovas D, Roquer J, Cardona P, Ribó M, Martí-Fàbregas J, Abilleira S, Chamorro Á; Catalan Stroke Code and Reperfusion Consortium (Cat-SCR). 2014;38(6):418-24. doi: 10.1159/000369121. Epub 2014 Dec 3. PMID: 25472576.

    Implantable loop recorder: a new tool in the diagnosis of cryptogenic stroke. Rev Esp Cardiol (Engl Ed).

    Mercé J, Garcia M, Ustrell X, Pellisé A, de Castro R, Bardají A. 2013 Aug;66(8):665-6. doi: 10.1016/j.rec.2013.02.001. Epub 2013 Apr 17. PMID: 24776339.

    Embolia aérea por mecanismo venoso retrógrado como causa de ictus isquémico [Retrograde venous cerebral air embolism as a cause of stroke]. Neurologia.

    Pellisé A, Ustrell X, Ruiz V, Guedea A. 2012 Mar;27(2):119-21. Spanish. doi: 10.1016/j.nrl.2011.05.003. Epub 2011 Jul 30. PMID: 21802791.

    Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis. Neurology.

    Topakian R, King A, Kwon SU, Schaafsma A, Shipley M, Markus HS; ACES Investigators. 2011 Aug 23;77(8):751-8. doi: 10.1212/WNL.0b013e31822b00a6. Epub 2011 Aug 17. PMID: 21849657.

    Outcomes of intravenous thrombolysis after dissemination of the stroke code and designation of new referral hospitals in Catalonia: the Catalan Stroke Code and Thrombolysis (Cat-SCT) Monitored Study. Stroke.

    Abilleira S, Dávalos A, Chamorro A, Alvarez-Sabín J, Ribera A, Gallofré M; Catalan Stroke Code and Thrombolysis Study Group. 2011 Jul;42(7):2001-6. doi: 10.1161/STROKEAHA.110.605030. Epub 2011 May 12. PMID: 21566237.

    Optimizing protocols for risk prediction in asymptomatic carotid stenosis using embolic signal detection: the Asymptomatic Carotid Emboli Study. Stroke.

    King A, Shipley M, Markus H; ACES Investigators.2011 Oct;42(10):2819-24. doi: 10.1161/STROKEAHA.111.622514. Epub 2011 Aug 18. PMID: 21852607.

    Cardiac workup of ischemic stroke. Curr Cardiol Rev.

    Ustrell X, Pellisé A. 2010 Aug;6(3):175-83. doi: 10.2174/157340310791658721. PMID: 21804776; PMCID: PMC2994109.

    Persistent hyperglycemia >155 mg/dL in acute ischemic stroke patients: how well are we correcting it?: implications for outcome. Stroke.

    Fuentes B, Ortega-Casarrubios MA, Sanjosé B, Castillo J, Leira R, Serena J, Vivancos J, Dávalos A, Gil-Nuñez A, Egido J, Díez-Tejedor E; Stroke Project of the Cerebrovascular Diseases Study Group Spanish Society of Neurology. 2010 Oct;41(10):2362-5. doi: 10.1161/STROKEAHA.110.591529. Epub 2010 Aug 19. PMID: 20724713.

    The Asymptomatic Carotid Emboli Study: study design and baseline results. Int J Stroke.

    ACES Investigators. 2009 Oct;4(5):398-405. doi: 10.1111/j.1747-4949.2009.00339.x. PMID: 19765130.

    The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study. Stroke.

    Fuentes B, Castillo J, San José B, Leira R, Serena J, Vivancos J, Dávalos A, Nuñez AG, Egido J, Díez-Tejedor E; Stroke Project of the Cerebrovascular Diseases Study Group, Spanish Society of Neurology. 2009 Feb;40(2):562-8. doi: 10.1161/STROKEAHA.108.519926. Epub 2008 Dec 18. PMID: 19095970.

    Recurrent stroke and massive right-to-left shunt: results from the prospective Spanish multicenter (CODICIA) study. Stroke.

    Serena J, Marti-Fàbregas J, Santamarina E, Rodríguez JJ, Perez-Ayuso MJ, Masjuan J, Segura T, Gállego J, Dávalos A; CODICIA, Right-to-Left Shunt in Cryptogenic Stroke Study; Stroke Project of the Cerebrovascular Diseases Study Group, Spanish Society of Neurology. 2008 Dec;39(12):3131-6. doi: 10.1161/STROKEAHA.108.521427. Epub 2008 Sep 25. PMID: 18818401.

    Doppler transcraneal como herramienta diagnóstica de la fístula arteriovenosa pulmonar aislada [Diagnosis of isolated pulmonary arterio-venous fístula using contrast transcranial Doppler]. Neurologia.

    Aguirregomozcorta M, Ustrell X, Ramió-Torrentà LL, Serena J. 2006 Jan-Feb;21(1):40-3. Spanish. PMID: 16525926.

    The diagnosis and treatment of a patient with puerperal infection and subdural hygromas. Anesth Analg.

    Aragonès N, Arxer A, Vieito M, Ros J, Villalonga A, Ustrell X. 2004 Oct;99(4):1218-1220. doi: 10.1213/01.ANE.0000134814.93305.F8. PMID: 15385379.

    Encefalopatía hiperamoniémica asociada al uso de valproato sódico [Hyperammonemic encephalopathy associated with valproate acid]. Neurologia.

    Osuna MT, Burcet J, Ramió L, Ustrell X, Silva Y, Molins A. 2003 Jul- Aug;18(6):347-50. Spanish. PMID: 12838456.

Membres De L’equip

  • Responsable de grup

    • Dr. Xavier Ustrell

  • Responsable científic

    • Alan Flores

  • Investigadors adscrits al IISPV

    • Laia Seró
    • Jose Maria González
    • Ángela Monterde Ortega
    • Lidia Lara Lezama
    • Anna Pellisé Guinjoan
    • Alba Mañé Rodriguez
    • Paula Rodríguez Parajuá

  • Coordinadora de recerca clínica

    • Ylenia Avivar

Altres grups de Neurociències i Salut Mental

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