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Biomedical Research Unit (BRU)

METABOLIC AND NUTRITION DISEASES
BIOLOGICAL ASPECTS GENETICS
TARGETS

The Biomedical Research Unit is led by Prof. Jorge Joven and Dr. Jordi Camps, and has the experience of three senior collaborators and four post-doctoral researchers, in addition, three students are doing their doctoral thesis. The Unit has been funded uninterruptedly with the mission and vision of conducting basic and clinical research with effective transfer to clinical practice. The current projects are to investigate non-communicable diseases such as morbid obesity and liver disease, cardiovascular disease, cancer and urinary tract infections, whose relationship between metabolism, oxidation and inflammation is being studied. Specifically, the role of markers of inflammation and oxidation, the use of natural compounds for the treatment of pathologies associated with obesity, as well as the nature and origin of metabolic disorders using chromatographic techniques have been studied. Currently, the Instituto de Salud Carlos III and La Marató de TV3 are the two main bodies that finance current projects.

RESPONSIBLE

  • Dr. Jorge Joven Maried

  • Dr. Jordi Camps Andreu

  • Research lines
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The multidisciplinary profile of the research group makes the lines of research different, all with the common nexus of inflammation, oxidation and metabolism.

  • Inflammation and energy metabolism in obesity
  • Epigenetic modifications derived from the combination of diabetes and obesity
  • Molecular mechanisms and biological markers of metabolic processes resulting from the treatment of obesity
  • Biological markers in urinary tract infections
  • Effect of radiotherapy on oxidative stress and metabolic processes in cancer patients

    Last projects granted

  • Identification of biomarkers based on energy metabolism and oxidative stress in patients with urinary catheter-associated infections and development of biosensors for their determination in primary and hospital care (569/U/2018)
    Fundació La Marató de TV3
    2019-2021
    IP: Jordi Camps Andreu

  • Molecular mechanisms and biomarkers of metabolic and epigenetic processes mediated by obesity treatment (PI18/00921)
    Instituto de Salud Carlos III
    2019-2021
    IP: Jorge Joven Maried

  • The impact of energy metabolism on epigenetic modifications related to the combination of diabetes and obesity
    Fundació La Marató de TV3
    2017-2019
    IP: Jorge Joven Maried

    Year

    Effect of Vitamin D(3) on the PostprandialLipid Profile in Obese Patients: A Non-Targeted Lipidomics Study

    Fernández-Arroyo S, Hernández-Aguilera A, de Vries MA, Burggraaf B, van der Zwan E, Pouw N, Joven J, Cabezas MC
    Nutrients

    DOI: 10.3390/nu11051194

    Stratification of cancer anddiabetes based on circulating levels of formate and glucose

    Pietzke M, Arroyo SF, Sumpton D, Mackay GM, Martin-Castillo B, Camps J,Joven J, Menendez JA, Vazquez A; METTEN study group
    Cancer Metab

    DOI: 10.1186/s40170-019-0195-x

    Revisiting silibinin as a novobiocin-like Hsp90 C-terminal inhibitor:Computational modeling and experimental validation

    Cuyàs E, Verdura S, Micol V, Joven J, Bosch-Barrera J, Encinar JA, MenendezJA
    Food Chem Toxicol

    DOI: 10.1016/j.fct.2019.110645

    Chemokine (C-C motif) ligand 2 and coronary artery disease: Tissue expression of functional and atypical receptors

    Hernández-Aguilera A, Fibla M, Cabré N, Luciano-Mateo F, Camps J,Fernández-Arroyo S, Martín-Paredero V, Menendez JA, Sirvent JJ, Joven J
    Cytokine

    DOI: 10.1016/j.cyto.2019.154923

    Alterationsin plasma concentrations of energy-balance-related metabolites in patients withlung, or head & neck, cancers: Effects of radiotherapy

    Rodríguez-Tomàs E, Arguís M, Arenas M, Fernández-Arroyo S, Murcia M, SabaterS, Torres L, Baiges-Gayà G, Hernández-Aguilera A, Camps J, Joven J
    J Proteomics

    DOI: 10.1016/j.jprot.2019.103605

    Plasma metabolic alterations in patients with severe obesity and non-alcoholic steatohepatitis

    Cabré N, Luciano-Mateo F, Baiges-Gayà G, Fernández-Arroyo S, Rodríguez-Tomàs E, Hernández-Aguilera A, París M, Sabench F, Del Castillo D, López-Miranda J, Menéndez JA, Camps J, Joven J.
    Aliment Pharmacol Ther. 2020 Feb;51(3):374-387.

    DOI: 10.1111/apt.15606

    Clinical value of procalcitonin in critically ill patients infected by SARS-CoV-2

    Garrido P, Cueto P, Rovira C, Garcia E, Parra A, Enriquez R, Pinos A, Sosa M, Hernández-Aguilera A, Vallverdú I.
    2020 Nov 8 [Epub ahead of print]. Am J Emerg Med.

    DOI: 10.1016/j.ajem.2020.11.011

    Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro

    Herranz-López M, Olivares-Vicente M, Rodríguez Gallego E, Encinar JA, Pérez-Sánchez A, Ruiz-Torres V, Joven J, Roche E, Micol V.
    Food Chem Toxicol. 2020 Oct;144:111606.

    DOI: 10.1016/j.fct.2020.111606

    Alterations in plasma concentrations of energy-balance-related metabolites in patients with lung, or head & neck, cancers: Effects of radiotherapy

    Rodríguez-Tomàs E, Arguís M, Arenas M, Fernández-Arroyo S, Murcia M, Sabater S, Torres L, Baiges-Gayà G, Hernández-Aguilera A, Camps J, Joven J.
    J Proteomics. 2020 Feb 20;213:103605.

    DOI: 10.1016/j.jprot.2019.103605

    Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain

    Iftimie S, López-Azcona AF, Vicente-Miralles M, Descarrega-Reina R, Hernández-Aguilera A, Riu F, Simó JM, Garrido P, Joven J, Camps J, Castro A.
    PLoS One. 2020 Sep 3;15(9):e0234452.

    DOI: 10.1371/journal.pone.0234452

    Chemokine C-C motif ligand 2 overexpression drives tissue-specific metabolic responses in the liver and muscle of mice

    Luciano-Mateo F, Cabré N, Fernández-Arroyo S, Baiges-Gaya G, Hernández-Aguilera A, Rodríguez-Tomàs E, Muñoz-Pinedo C, Menéndez JA, Camps J, Joven J.
    Sci Rep. 2020 Jul 20;10(1):11954.

    DOI: 10.1038/s41598-020-68769-7

    Multiplexed monitoring of a novel autoantibody diagnostic signature of colorectal cancer using HaloTag technology-based electrochemical immunosensing platform

    Garranzo-Asensio M, Guzmán-Aránguez A, Povedano E, Ruiz-Valdepeñas Montiel V, Poves C, Fernandez-Aceñero MJ, Montero-Calle A, Solís-Fernández G, Fernandez-Diez S, Camps J, Arenas M, Rodríguez-Tomàs E, Joven J, Sanchez-Martinez M, Rodriguez N, Dominguez G, Yáñez-Sedeño P, Pingarrón JM, Campuzano S, Barderas R.
    Theranostics. 2020 Feb 10;10(7):3022-3034.

    DOI: 10.7150/thno.42507

    Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

    Luciano-Mateo F, Cabré N, Baiges-Gaya G, Fernández-Arroyo S, Hernández-Aguilera A, Elisabet Rodríguez-Tomàs E, Arenas M, Camps J, Menéndez JA, Joven J.
    Aging (Albany NY). 2020 Oct 26;12(20):20001-20023.

    DOI: 10.18632/aging.104154

    Effects of radiotherapy on plasma energy metabolites in patients with breast cancer who received neoadjuvant chemotherapy

    Arenas M, Fernández-Arroyo S, Rodríguez-Tomàs E, Sabater S, Murria Y, Gascón M, Amillano K, Melé M, Camps J, Joven J.
    Clin Transl Oncol. 2020 Jul;22(7):1078-1085.

    DOI: 10.1007/s12094-019-02232-6

    Plasma metabolic alterations in patients with severe obesity and non-alcoholic steatohepatitis

    Cabré N, Luciano-Mateo F, Baiges-Gayà G, Fernández-Arroyo S, Rodríguez-Tomàs E, Hernández-Aguilera A, París M, Sabench F, Del Castillo D, López-Miranda J,Menéndez JA, Camps J, Joven J
    Aliment Pharmacol Ther

    DOI: 10.1111/apt.15606

    Influence of Surgical Procedures on Serum Paraoxonase-1-Related Variables and Markers of Inflammation in Hospitalized Patients

    Iftimie S, Escribano A, Díez-Sans A, Albiciuc I, Hernández-Aguilera A,Fort-Gallifa I, López-Azcona AF, Camps J, Joven J, Castro A
    J Invest Surg

    DOI: 10.1080/08941939.2019.1597223

    Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers

    Pérez-Sánchez A, Cuyàs E, Ruiz-Torres V, Agulló-Chazarra L, Verdura S,González-Álvarez I, Bermejo M, Joven J, Micol V, Bosch-Barrera J, Menendez JA
    Int J Mol Sci

    DOI: 10.3390/ijms20071606

    Chemokine (C-C motif) ligand 2 gene ablation protects low-densitylipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation

    Luciano-Mateo F, Cabré N, Fernández-Arroyo S, Baiges-Gaya G,Hernández-Aguilera A, Rodríguez-Tomàs E, Mercado-Gómez M, Menendez JA, Camps J,Joven J
    Biochim Biophys Acta Mol Basis Dis

    DOI: 10.1016/j.bbadis.2019.03.006

    Versatile Electroanalytical Bioplatforms for Simultaneous Determination ofCancer-Related DNA 5-Methyl- and 5-Hydroxymethyl-Cytosines at Global andGene-Specific Levels in Human Serum and Tissues

    Povedano E, Montiel VR, Valverde A, Navarro-Villoslada F, Yáñez-Sedeño P,Pedrero M, Montero-Calle A, Barderas R, Peláez-García A, Mendiola M, Hardisson D,Feliú J, Camps J, Rodríguez-Tomàs E, Joven J, Arenas M, Campuzano S, PingarrónJM
    ACS Sens

    DOI: 10.1021/acssensors.8b01339

    Neoadjuvant Metformin Added to Systemic Therapy Decreases theProliferative Capacity of Residual Breast Cancer

    208: Lopez-Bonet E, Buxó M, Cuyàs E, Pernas S, Dorca J, Álvarez I, Martínez S,Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Oliveras G, Meléndez C,Castillo L, Verdura S, Brunet J, Joven J, Garcia M, Saidani S, Martin-Castillo B,Menendez JA
    J Clin Med

    DOI: 10.3390/jcm8122180

    Metformin induces a fasting- and antifolate-mimicking modification of systemichost metabolism in breast cancer patients

    Cuyàs E, Fernández-Arroyo S, Buxó M, Pernas S, Dorca J, Álvarez I, Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K, Domínguez S, Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Verdura S, Brunet J,López-Bonet E, Garcia M, Saidani S, Joven J, Martin-Castillo B, Menendez JA
    Aging (Albany NY)

    DOI: 10.18632/aging.101960

    The C Allele of ATM rs11212617 Associates With Higher PathologicalComplete Remission Rate in Breast Cancer Patients Treated With NeoadjuvantMetformin

    Cuyàs E, Buxó M, Ferri Iglesias MJ, Verdura S, Pernas S, Dorca J, Álvarez I,Martínez S, Pérez-Garcia JM, Batista-López N, Rodríguez-Sánchez CA, Amillano K,Domínguez S, Luque M, Morilla I, Stradella A, Viñas G, Cortés J, Joven J, Brunet J, López-Bonet E, Garcia M, Saidani S, Queralt Moles X, Martin-Castillo B,Menendez JA
    Front Oncol

    DOI: 10.3389/fonc.2019.00193

    An olive oil phenolic is a new chemotype of mutant isocitrate dehydrogenase 1(IDH1) inhibitors

    Verdura S, Cuyàs E, Lozano-Sánchez J, Bastidas-Velez C, Llorach-Parés L,Fernández-Arroyo S, Hernández-Aguilera A, Joven J, Nonell-Canals A, Bosch-BarreraJ, Martin-Castillo B, Vellon L, Sanchez-Martinez M, Segura-Carretero A, Menendez JA
    Carcinogenesis

    DOI: 10.1093/carcin/bgy159

    Effects of radiotherapy on plasma energymetabolites in patients with breast cancer who received neoadjuvant chemotherapy

    Arenas M, Fernández-Arroyo S, Rodríguez-Tomàs E, Sabater S, Murria Y, Gascón M, Amillano K, Melé M, Camps J, Joven J
    Clin Transl Oncol

    DOI: 10.1007/s12094-019-02232-6

    In silico clinical trials for anti-aging therapies

    Menendez JA, Cuyàs E, Folguera-Blasco N, Verdura S, Martin-Castillo B, Joven J, Alarcón T
    Aging (AlbanyNY)

    DOI: 10.18632/aging.102180

    Serum Paraoxonase-1-Related Variables andLipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect ofRadiotherapy

    Rodríguez-Tomàs E, Murcia M, Arenas M, Arguís M, Gil M, Amigó N, Correig X,Torres L, Sabater S, Baiges-Gayà G, Cabré N, Luciano-Mateo F, Hernández-Aguilera A, Fort-Gallifa I, Camps J, Joven J
    Antioxidants (Basel)

    DOI: 10.3390/antiox8070213

    Laparoscopic sleeve gastrectomy reversesnon-alcoholic fatty liver disease modulating oxidative stress and inflammation

    Cabré N, Luciano-Mateo F, Fernández-Arroyo S, Baiges-Gayà G,Hernández-Aguilera A, Fibla M, Fernández-Julià R, París M, Sabench F, CastilloDD, Menéndez JA, Camps J, Joven J
    Metabolism

    DOI: 10.1016/j.metabol.2019.07.002

    Computational de-orphanization of the oliveoil biophenol oleacein: Discovery of new metabolic and epigenetic targets

    Cuyàs E, Castillo D, Llorach-Parés L, Lozano-Sánchez J, Verdura S,Nonell-Canals A, Brunet J, Bosch-Barrera J, Joven J, Valdés R, Sanchez-MartinezM, Segura-Carretero A, Menendez JA
    FoodChem Toxicol

    DOI: 10.1016/j.fct.2019.05.037

    Correction : Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation.

    Riera-Borrull M, Cuevas VD, Alonso B, Vega MA, Joven J, Izquierdo E, Corbí ÁL.
    Immunol

    DOI: 10.1016/j.fct.2019.05.037

    Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease.

    Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernández V, Vasconcelos N, Peddinti G, Adrover A, Jové M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabré N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Orešič M, Fort J, Errasti-Murugarren E, Rodrígues CMP, Orozco M, Joven J, Cantó C, Palacin M, Fernández-Veledo S, Vendrell J, Zorzano A.
    Cell.

    DOI: 10.1016/j.cell.2019.04.010

    Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells.

    De la Luz Cádiz-Gurrea M, Micol V, Joven J, Segura-Carretero A, Fernández-Arroyo S.Food Res Int.

    DOI: 10.1016/j.foodres.2018.02.027

  • Title: PI18/00921 Mecanismos moleculares y marcadores biológicos de los procesos metabólicos y epigenéticos que resultan del tratamieto de la obesidad.

    Funding entity: Instituto Carlos III

    Duration: 2019-2021

    Principal Investigator: Jorge Joven Maried

  • Title: The impact of energy metabolism on epigenetic modifications related to the combination of diabetes and obesity

    Funding entity: Fundació La Marató TV3

    Duration: 2017-2020

    Principal Investigator: Jorge Joven Maried

  • Title: 201807-10 569/U/2018 Identification of biomarkers based on the energy metabolism and oxidative stress in patients with catheter-associated urinary infections and development of biosensors for their determination in primary and hospital care.

    Funding entity: Fundació La Marató TV3

    Duration: 2019-2022

    Principal Investigator: Jordi Camps Andreu

  • Títol: Cisgenic mice overproducing mcp-1

    Número de sol·licitud: PCT/ES2014/070201

    Autors: 46027207K-Joven Married Jorge; 36975098E-Alonso Villaverde Carlos; 39732667Y Aragonès Bargallo Gerard; 47764837R Rull Aixa Anna; 24392806H Beltran Debón Raúl; 39910749E Rodríguez Gallego Esther

    Patent concedida

  • Títol: Diagnosis of non-alcoholic hepatic steatosis

    Número de sol·licitud: EP1977249A2

    Autors: 46027207K-Joven Married, Jorge; 39877286R-Ras Mallorquí Maria; 47760840Y-Marine Fortuny Sílvia; 47629776L-Maijó Ferre Irene; 21676567X-Fernandez Arroyo Salvador; 39910749E-Rodríguez Gallego Esther

    Patent concedida

  • Títol: Transgenic mice overproducing MCP-1 and KNOCK-OUT through the receptor CCR2

    Número de la sol·licitud: P201530866

    Autors: 46027207-Joven Married Jorge; 51112259A-Nicaury Luciano Mateo; 47770337G-Guirro Castellnou Maria; 77787771T-Hernández Aguilera Anna; 39918661E-Mariné Casado Roger; 21676567X-Fernández Arroyo Salvador; 39910749E-Rodríguez Gallego, Esther

    Patent abandonada

Team Members

  • Group leader

    • Dr. Jorge Joven Maried
    • Dr. Jordi Camps Andreu

  • Senior researcher

    • Dra. Meritxell Arenas Prat
    • Carlos Alonso-Villaverde
    • Vicente Martín Paredero
    • Mercè Hernández

  • Postdoctoral Researcher

    • Salvador Fernández Arroyo
    • Montserrat Fibla Simó
    • Anna Hernández Aguilera
    • Isabel Fort Gallifa

  • PhD student

    • Gerard Baiges Gayà
    • Elisabet Rodríguez Tomàs
    • Helena Castañé Vilafranca

Altres grups de Metabolic and Nutrition Diseases

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