The Infection and Immunity group (INIM) is a research group specialized in the study of infectious diseases, focusing its main activity on the field of HIV immunopathogenesis. HIV is a complex and multifactorial phenomenon that affects the normal function of the immune system. The group leaders are Dr. Joaquim Peraire and Dr. Anna Rull, who lead a mixed group made up of clinical and basic researchers.
Dra. Anna Rull Aixa
Dr. Joaquim Peraire Forner
The group, which was created in 1995 by Professor Francesc Vidal, Dr. Joaquim Peraire and Dr. Consuelo Viladés, develops its activity at the Joan XXIII University Hospital (HJ23) in Tarragona and at the Rovira i Virgili University (URV), being the Foundation Institute of Investigació Sanitària Pere Virgili (IISPV) the manager of its main activity. In 2022, INIM joined the AIDS Research Network (RETIC-RIS) (RD16/0025/0006) of the Instituto de Salud Carlos III (ISCIII) (CB21/13/0020), and currently, it is part of the CIBERINFEC national network. INIM is recognized as a group of excellence by the Agency for the Management of University and Research Grants (AGAUR) of the Generalitat de Catalunya.
The main activity of the group is focused on clinical and translational research being the applicability of omic sciences concerning the field of HIV/AIDS, and more recently the SARS-CoV-2 infection, the main goal during the last years. The group understands quality biomedical and health research as a cooperative activity collaborating with different national and international institutions. On the other hand, INIM has extensive experience in the training of undergraduate students, postgraduate students, doctoral theses and postdoctoral training. In addition, the members of the group also provide teaching and training activities in the academic field.
The research lines of the INIM group are within the field of infectious diseases, most of them focusing on HIV:
Title: A MULTI-OMIC SUBSTUDY FOR THE CLINICAL TRIAL “dtg/3tc vs. bic/ftc/taf maintenance therapy in people living with HIV: an open-label randomized clinical trial.
Funding entity: Fundación SEIMC-GeSIDA.
Duration: 2021-2025
Principal Investigator: Anna Rull Aixa / Francesc Vidal Marsal / Joaquim Peraire Forner
Title: Role of the gut microbiome in lipid and lipoprotein function: Immune recovery and HIV disease progression (LipoHIV). PI20/00326
Funding entity: Instituto de Salud Carlos III (ISCIII).
Duration: 2022-2024
Principal Investigator: Anna Rull Aixa
Title: Omics profile associated with HIV disease progression: looking for new biomarkers and for new therapeutic targets to achieve HIV functional cure.
Funding entity: Fondo de Investigación Sanitaria. Instituto de Salud Carlos III (ISCIII).
Duration: 2020-2023
Principal Investigator: Francesc Vidal Marsal
Collaboration. co-IP: Joaquim Peraire Forner.
Title: 2019/IISPV/05, Evaluation of sTWEAK/Fn14/CD163 axis as potential predictive biomarkers of immunological recovery and disease progression in HIV-infected patients under virological suppression.
Funding entity: Institut d’Investigació Sanitària Pere Virgili (IISPV).
Duration: 2020-2021
Principal Investigator: Anna Rull Aixa
Title: Circulating and cellular prognostic biomarkers for COVID19 progression in patient with SARS-CoV-2 infection using multi omic science.
Funding entity: Generalitat de Catalunya
Duration: 2020
Principal Investigator: Francesc Vidal Marsal
Title: EUIN2017-89297, Role of the gut microbiome in lipoprotein function and stability: immune recovery and HIV disease progression
Funding entity: Ministerio de Economía, Industria y Competitividad.
Duration: 2018-2019
Principal Investigator: Anna Rull Aixa
(Patent)
Title: Methods for the prognosis of HIV-Infected subjects
Reference: EP18382669.2 – PCT/EP2019/074906
Inventors: Rodriguez Gallego, Esther; Rull Aixa, Anna; Peraire Forner, Joaquim; Viladés Laborda, Consuelo; Vidal Marsal, Francesc; Alba Elvira, Veronica; Ruiz-Mateos Carmona, Eziquiel; López Cortés, Luis Fernando; Tarancón Díez, Laura.
Registration date: 2019
Mensa J, et al (Vidal F). Guia de Terapéutica Antimicrobiana 2022. Editorial Antares, Barcelona 2022. ISBN: 978-84-88825-31-5.
Mensa J, et al (Vidal F). Guia de Terapéutica Antimicrobiana 2021. Editorial Antares, Barcelona 2021. ISBN: 978-84-88825-33-9.
Mallolas J, et al (Vidal F). Guia Práctica del SIDA. Clínica, Diagnóstico y Tratamiento, 16ª Ed. Editorial Antares, Barcelona 2021. ISBN: 978-84-88825-30-8.
Mensa J, et al (Vidal F). Guia de Terapéutica Antimicrobiana 2020. Editorial Antares, Barcelona 2020. ISBN: 978-84-88825-29-2.
Panel de expertos de GeSIDA y Plan Nacional del SIDA: Martinez E, Arribas JR, Polo R, Gonzalez J, Palacios R, Berenguer J, Bernal E, Blanco JR, Curran A, de Mendoza C, Domingo P, Dueñas C, Estrada V, Galindo MJ, González-Cordón A, Gutiérrez F, Iribarren JA, Imaz A, Mariño A, Miralles C, Miró JM, Montes ML, Moreno S, Paredes R, Perez-Molina JA, Pérez-Elias MJ, Pulido F, Ribera E, Rivero A, Rubio R, Ryan P, Sanchez-Conde M, Sanz J, Sanz J, Serrano S, Suarez I, Torralba M, Tuset M, Velasco I, Viciana P, Vidal F, von Vichmann M. Documento de consenso de GeSIDA / Plan Nacional del Sida respecto al tratamiento antiretroviral en adultos infectados por el VIH. Ministerio de Sanidad, Gobierno de España, 2020.
Mensa J; Soriano A; García-Sánchez JE; Letang E; López-Suñé E; Marco F, Llinares P. Guía de Terapéutica Antimicrobiana 2019. (Spain): Antares Editorial, 2019. ISBN-13: 9788488825292.
Mensa J, et al (Vidal F). Guia de Terapéutica Antimicrobiana 2019. Editorial Antares, Barcelona 2019. ISBN: 978-84-88825-26-1.
Clotet B, et al (Vidal F). Guia Práctica del SIDA. Clínica, Diagnóstico y Tratamiento, 15ª Ed. Editorial Antares, Barcelona 2019. ISBN: 978-84-88825-28-5.
Panel de expertos de GeSIDA y Plan Nacional del SIDA: Perez-Molina JA, Polo R, Martinez E, Gonzalez J, Lozano F, Aguirrebengoa K, Arribas JR, Berenguer J, Blanco JR, Boix V, Curran A, Domingo P, Dueñas C, Estrada V, Galindo MJ, Garcia F, Gutiérrez F, Iribarren JA, Imaz A, Knobel H, Llibre JM, Losa JE, Mariño A, Miralles C, Miró JM, Montes ML, Moreno S, Pérez-Elias MJ, Pulido F, Ribera E, Rivero A, Rubio R, Ryan P, Sanchez-Conde M, Sanz J, Sanz J, Serrano S, de la Torre J, Tuset M, Vidal F, von Vichmann M. Documento de consenso de GeSIDA / Plan Nacional del Sida respecto al tratamiento antirretroviral en adultos infectados por el VIH. Ministerio de Sanidad, Consumo y Bienestar Social, Gobierno de España, 2019.
Mensa J; Gatell JM; García-Sánchez JE; Letang E; López-Suñé E; Marco F. Guía de Terapéutica Antimicrobiana 2018. (Spain): Antares Editorial, 2018. ISSN-e 2255-0569.
Mensa J, et al (Vidal F). Guía de Terapéutica Antimicrobiana 2018. Editorial Antares, Barcelona 2018. ISBN: 978-84-88825-24-7.
Ceperuelo-Mallafré V, Reverté L, Peraire J, Madeira A, Maymó-Masip E, López-Dupla M, Gutierrez-Valencia A, Ruiz-Mateos E, Buzón MJ, Jorba R, Vendrell J, Auguet T, Olona M, Vidal F, Rull A, Fernández-Veledo S.
Front Immunol. 2022;13:912579.
PMID: 36189213.
Masip J, Jorba R, López-Dupla M, Domingo P, Pacheco YM, García-Pardo G, Martínez E, Viladés C, Veloso S, Alba V, Olona M, Vidal F, Gómez-Bertomeu F, Peraire J, Rull A.
Int J Mol Sci. 2022;23(15):8071.
PMID: 35897644.
DOI: 10.3390/ijms23158071
Masip J, Rallón N, Yeregui E, Olona M, Resino S, Benito JM, Viladés C, García-Pardo G, Alcamí J, Ruiz-Mateos E, Gómez-Bertomeu F, Vargas M, Navarro M, Oteo JA, Pineda JA, Martí A, Alba V, Vidal F, Peraire J, Rull A.
Front Immunol. 2022;13:822272.
PMID: 35514981.
Reverté L, Yeregui E, Olona M, Gutiérrez-Valencia A, Buzón MJ, Martí A, Gómez-Bertomeu F, Auguet T, López-Cortés LF, Burgos J, Benavent-Bofill C, Boqué C, García-Pardo G, Ruiz-Mateos E, Mestre MT, Vidal F, Viladés C, Peraire J, Rull A; COVIDOMICS Study Group.
Clin Transl Med. 2022;12(1):e704.
PMID: 35075803. PMCID: PMC8787095
DOI: 10.1002/ctm2.704
Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, Lichterfeld M, Yu XG, Gaiha GD, Allen TM, Walker BD. Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity. 2021 Oct 12;54(10):2372-2384.e7. Epub 2021 Sep 7. PMID: 34496223; PMCID: PMC8516715
Tarancón-Diez L, Rull A, Herrero P, Vazquez-Alejo E, Peraire J, Guillén S, Navarro-Gomez ML, Viladés C, Muñoz-Fernández MÁ, Vidal F.
J Antimicrob Chemother. 2021;76(11):2993-3001.
PMID: 34463735.
DOI: 10.1093/jac/dkab277
Malo AI, Peraire J, Ruiz-Mateos E, Masip J, Amigó N, Alcamí J, Moreno S, Girona J, García-Pardo G, Reig R, Vidal F, Castro A, Masana L, Rull A.
Front Immunol. 2021;12:730691.
PMID: 34650556. PMCID: PMC8505996
Masip J, Gasca-Capote C, Jimenez-Leon MR, Peraire J, Perez-Gomez A, Alba V, Malo AI, Leal L, Martín CR, Rallón N, Viladés C, Olona M, Vidal F, Ruiz-Mateos E, Rull A; ECRIS integrated in the Spanish AIDS Research Network.
Clin Transl Med. 2021;11(7):e474.
PMID: 34323411. PMCID: PMC8255061
DOI: 10.1002/ctm2.474
Castro de Moura M, Davalos V, Planas-Serra L, Alvarez-Errico D, Arribas C, Ruiz M, Aguilera-Albesa S, Troya J, Valencia-Ramos J, Vélez-Santamaria V, Rodríguez-Palmero A, Villar-Garcia J, Horcajada JP, Albu S, Casasnovas C, Rull A, Reverte L, Dietl B, Dalmau D, Arranz MJ, Llucià-Carol L, Planas AM, Pérez-Tur J, Fernandez-Cadenas I, Villares P, Tenorio J, Colobran R, Martin-Nalda A, Soler-Palacin P, Vidal F, Pujol A, Esteller M.
EBioMedicine. 2021;66:103339.
PMID: 33867313. PMCID: PMC8047083
Yeregui E, Viladés C, Domingo P, Ceausu A, Pacheco YM, Veloso S, Inciarte A, Vidal-González J, Peraire M, Perpiñán C, Falcó V, Masip J, Alba V, Vargas M, Martí A, Reverté L, Mallolas J, Vidal F, Peraire J, Rull A.
EBioMedicine. 2020;62:103077.
PMID: 33166788. PMCID: PMC7653063
Rosado-Sánchez I, De Pablo-Bernal R, Rull A, Gónzalez J, Moreno S, Vinuesa D, Estrada V, Muñoz-Fernández MÁ, Vidal F, Leal M, Pacheco YM.
Front Immunol. 2020;11:581307.
PMID: 33240269. PMCID: PMC7677300
Solans-Laqué R, Rodriguez-Carballeira M, Rios-Blanco JJ, Fraile G, Sáez-Comet L, Martinez-Zapico A, Frutos B, Solanich X, Fonseca-Aizpuru E, Pasquau-Liaño F, Zamora M, Oristrell J, Fanlo P, Lopez-Dupla M, Abdilla M, García-Sánchez I, Sopeña B, Castillo MJ, Perales I, Callejas JL.
Arthritis Care Res (Hoboken). 2020;72(7):1001-1010.
PMID: 31033198.
DOI: 10.1002/acr.23912
Guerrero-Beltrán C, Martínez-Sanz J, Álvarez M, Olalla J, García-Álvarez M, Iribarren JA, Masiá M, Montero M, García-Bujalance S, Blanco JR, Rivero M, García-Fraile LJ, Espinosa N, Rodríguez C, Aguilera A, Vidal-Ampurdanes MC, Martínez M, Iborra A, Imaz A, Gómez-Sirvent JL, Peraire J, Portilla J, Caballero E, Alejos B, García F, Moreno S; CoRIS.
J Antimicrob Chemother. 2020;75(5):1294-1300.
PMID: 32030406.
DOI: 10.1093/jac/dkaa009
Curran A, Rull A, Navarro J, Vidal-González J, Martin-Castillo M, Burgos J, Falcó V, Ribera E, Torrella A, Planas B, Peraire J, Crespo M.
J Clin Med. 2020;9(5):1246.
PMID: 32344934. PMCID: PMC7288166
DOI: 10.3390/jcm9051246
Hernández-Walias F, Ruiz-de-León MJ, Rosado-Sánchez I, Vázquez E, Leal M, Moreno S, Vidal F, Blanco J, Pacheco YM, Vallejo A.
Sci Rep. 2020;10(1):2937.
PMID: 32076107.
Vitallé J, Terrén I, Orrantia A, Pérez-Garay R, Vidal F, Iribarren JA, Rodríguez C, Lirola AML, Bernal E, Zenarruzabeitia O, Borrego F.
Cell MolImmunol. 2019;16(12):940-942.
PMID: 31467415.
Ceausu A, Rodríguez-Gallego E, Peraire J, López-Dupla M, Domingo P, Viladés C, Vidal-Gonzalez J, Peraire M, Perpiñán C, Pacheco YM, Veloso S, Alba V, Vargas M, Castellano AJ, Ruiz-Mateos E, Mallolas J, Vidal F, Rull A.
Sci Rep. 2019;9(1):15722.
PMID: 31673011. PMCID: PMC6823538
Gutierrez MDM, Mateo MG, Corbacho N, Vidal F, Domingo P.
Expert Opin Drug Metab Toxicol. 2019;15(10):787-802.
PMID: 31512529.
Teira R, Espinosa N, Gutiérrez MM, Montero M, Martínez E, González F, Lozano de León F, Téllez F, Galindo MJ, Peraire J, Deig E, Muñoz-Sánchez P; para el Grupo de estudio VACH.
Enferm Infecc Microbiol Clin. 2019;37(6):361-366.
PMID: 30514587.
Alvarez M, Casas P, de Salazar A, Chueca N, Guerrero-Beltran C, Rodríguez C,Imaz A, Espinosa N, García-Bujalance S, Pérez-Elías MJ, García-Alvarez M, Iribarren JA, Santos J, Dalmau D, Aguilera A, Vinuesa D, Gutiérrez F, Piérola B, Molina JM, Peraire J, Portilla I, Gómez-Sirvent JL, Olalla J, Galera C, Blanco JR, Riera M, García-Fraile L, Navarro G, Curran A, Poveda E, García F; CoRIS.
J Antimicrob Chemother. 2019;74(6):1693-1700.
PMID: 30838386.
DOI: 10.1093/jac/dkz067
Gutierrez MDM, Mateo MG, Vidal F, Domingo P.
Expert Rev Clin Pharmacol. 2019;12(5):389-396.
PMID: 31017494.
Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, Blanco J, Vidal F, Pacheco YM, Rull A.
Clin Sci (Lond). 2019;133(8):997-1010.
PMID: 30952809.
DOI: 10.1042/CS20190111
Masiá M, Padilla S, García JA, García-Abellán J, Fernández M, Bernardino I, Montero M, Peraire J, Pernas B, Gutiérrez F.
PLoS One. 2019;14(4):e0215507.
PMID: 31026289.
Tarancon-Diez L, Rodríguez-Gallego E, Rull A, Peraire J, Viladés C, Portilla I, Jimenez-Leon MR, Alba V, Herrero P, Leal M, Ruiz-Mateos E, Vidal F; ECRIS integrated in the Spanish AIDS Research Network.
EBioMedicine. 2019;42:86-96.
PMID: 30879922. PMCID: PMC6491381
Llibre JM, Montoliu A, Miró JM, Domingo P, Riera M, Tiraboschi J, Curran A, Homar F, Ambrosioni J, Abdulghani N, Force L, Peraire J, Casabona J; PISCIS Cohort group.
HIV Med. 2019;20(3):237-247.
PMID: 30688007.
DOI: 10.1111/hiv.12710
Rodríguez-Gallego E, Tarancón-Diez L, García F, Del Romero J, Benito JM, Alba V, Herrero P, Rull A, Dominguez-Molina B, Martinez-Madrid O, Martin-Pena L, Pulido F, León A, Rodríguez C, Rallón N, Peraire J, Viladés C, Leal M, Vidal F, Ruiz-Mateos E; HIV-1 Elite Controllers Study Group (ECRIS), Spanish AIDS ResearchNetwork.
J Infect Dis. 2019;219(6):867-876.
PMID: 30312441.
Jarrin I, Suarez-Garcia I, Moreno C, Tasias M, Del Romero J, Palacios R, Peraire J, Gorgolas M, Moreno S; Cohort of the Spanish HIV/AIDS Research Network (CoRIS).
AntivirTher. 2019;24(3):167-175.
PMID: 30747107.
DOI: 10.3851/IMP3297
Hospital Universitari de Tarragona Joan XXIII
Edifici Modular de Docència i Recerca, Planta 1, Sala de Treball 3
C/ Dr. Mallafrè Guasch, 4
43007 Tarragona
Joaquim Peraire: jjperaire.hj23.ics@gencat.cat
Anna Rull: anna.rull@iispv.cat
see google mapsResponsible: Jael Lorca Cabrera, Estrella Martínez Segura
Responsible: Laureano Jiménez Esteller
Responsible: Dr. Youcef Azeli
Responsible: Dra. Carolina Serena Perelló