Unidad de Investigación en Pediatría, Nutrición y Desarrollo Humano (PEDINUR)

ENFERMEDADES METABÓLICAS Y NUTRICIÓN
OBJETIVO

La Unidad de Investigación en Pediatría, Nutrición y Desarrollo Humano (PEDINUR) es un grupo de investigación multidisciplinario que tiene como objetivo realizar una investigación de calidad, colaborando estrechamente con otros grupos de investigación y también con los profesionales responsables de la práctica clínica, y que ayude a dar respuestas a los problemas de salud más comunes que actualmente afectan en la población pediátrica.

RESPONSABLES
  • Dr. Joaquín Escribano Subias

  • PRESENTACIÓN
  • Líneas de investigación
  • Miembros del grupo
  • Proyectos
  • Tranferencia
  • Publicaciones
  • Difusión
  • Contacto

Sus principales líneas de investigación se enmarcan dentro del estudio de problemas de salud relacionados con la nutrición, como la obesidad o la enfermedad celiaca, y también sobre el efecto de la alimentación del lactante en su salud y desarrollo posterior mediante la ‘programación metabólica’. PEDINUR té también por objetivo desarrollar, desde un enfoque de ‘Medicina Basada en la Evidencia’, revisiones críticas y sistemáticas de la literatura de aspectos relacionados con sus líneas de investigación.

Línea: nutrición y metabolismo infantil

  • Programación metabólica precoz
  • Obesidad infantil: estudio de factores de riesgo cardiovascular, síndrome meta-bòlic y estrategias de intervención
  • Nutrición aplicada

Investigador principal: Ricardo Closa y Joaquín Escribano

Línia: gastroenterología y nutrición

  • Enfermedad celiaca

Investigador principal: Gema Castillejo

Línea: función pulmonar e infecciones en la edad pediátrica
Investigador principal: Ricardo Closa y Joaquín Escribano

Línia: medicina basada en la evidencia

  • Revisiones sistemáticas de la literatura
  • Evaluación de la composición corporal

Investigador principal: Verònica Luque

Exposoma y salud metabólica

  • Caracterización del exposoma de la vida temprana.
  • Metabolómica aplicada al desarrollo temprano

Investigadora Principal: Noelia Ramírez

  • Project title: Administración de dexametasona en primer episodio de infección del tracto urinario febril, como prevención de daño renal (DEXCAR)

    IP: Joaquin Escribano Subias

    Funding agency: Instituto de Salud Carlos IIII

    Financing (in thousands of euros): 40.150,00 €

    Duration (financing period): 01/01/2014 – 31/12/2017

    Project reference: PI13/002557

  • Project title: Eficacia clínica y metabòlica del abordatge motivacional coordinado entre atención primaria y especialitzada para el tratamineto de la obesidad infnatil: ensayo clínico controlado y aletorizado (OBEMAT 2.0)

    IP: Ricardo Closa Monasterolo / Albert Feliu Rovira

    Funding agency: Instituto de Salud Carlos III

    Financing (in thousands of euros): 171.820,00 €

    Duration (financing period):01/01/2016 – 31/12/2018

    Project reference: PI15/00970

  • Project title: Desarrollo de un sistema de neurofeedback portable para el tratamiento de adolescentes y adultos jóvenes con dolor crónico

    IP: Jordi Miró Martínez

    Funding agency: PPN2015A Pla Estatal d’Investigació Científica y Tècnica i d’innovació 2013-2016. Programa Estatal de Foment de la Investigació Científica i Tècnica d`Excel·lència. Subprograma Estatal de Generació del Coneixement. Projectes d`R+D

    Financing (in thousands of euros): 103.080,00 €

    Duration (financing period): 01/01/2016 – 31/12/2018

    Project reference: PSI2015-70966-P

  • Project title: Identificación de un patrón de biomarcadores de dilatación de la aorta ascendente en ninos con valvulopatía aortica bicuspide

    IP: Rosa Collell Hernández

    Funding agency: Soceidad Española de cardiologia Pediátrica y Cardiopatías Congénitas

    Financing (in thousands of euros): 12.000,00 €

    Duration (financing period): 30/10/2018 – 30/10/2019

    Project reference: I Beca Fundación Menudos Corazones

  • Títol: Eficacia clínica y metabólica del abordaje motivacional coordinado entre atención primaria y especializada para el tratamiento de la obesidad infantil: ensayo clínico controlado y aleatorizado
    Referència: PI15/00970
    Entitat finançadora: Instituto de Salud Carlos III
    Anys: 01/01/2016 – 31/12/2019

  • Títol: JRC – GNNS and neonatal care
    Entitat finançadora: Joint Research Center
    Anys: 01/01/2020 – 31/03/2020

  • Project title: Estudio aleatorizado, controlado, doble ciego, de grupos paralelos e internacional para investigar los efectos de una fórmula de inicio que contiene proteïnes parcialment hidrolizadas sobre el crecimiento, seguridad y tolerancia en lactantes sanos nacidos a término (TENUTO)

    IP: Joaquín Escribano Subias

    Funding agency: Nutricia Research B.V.

    Financing (in thousands of euros): 76.600,00 €

    Duration (financing period): 13/12/2017 – 30/01/2020

  • Project title: Evaluation of nutritional suitability and tolerability of a human milk oligosaccharides (HMO) mix infant formula for term infant (JENEWEIN)

    IP: Joaquín Escribano Subias

    Funding agency: Jennewein Biothechnologie GMBH

    Financing (in thousands of euros): 195.840,00 €

    Duration (financing period): 10/09/2018 – 31/09/2020

    Project reference: JEN/008017

  • Títol: “Evaluation of nutritional suitability and tolerability of a human milk ligosaccharides (HMO) mix infant formula for term infant”
    Entitat finançadora: Jennewein Biotechnologie GmbH
    Anys: 01/01/2019 – 31/12/2020

  • Project title: Manteniment i extensió del Programa de recerca i tractament del dolor crònic infantil

    IP: Joaquín Escribano Subias

    Funding agency: l’HUSJR Diputació de Tarragona

    Financing (in thousands of euros): 20.299 €

    Duration (financing period): 20/09/2020 – 29/06/2021

  • Títol: EFECTO DE UN INTERVENCION MOTIVACIONAL SOBRE LA MICROBIOTA INTESTINAL Y LOS COMPONENTES DEL SINDROME METABOLICO EN UNA POBLACION OBESA PEDIATRICA: MICROBEKIDS.
    Referència: PI18/00226 IISPV
    Entitat finançadora: Instituto de Salud Carlos III
    Anys: 01/01/2019 – 31/12/2021

  • Title: 2017 SGR 01310 Suport a Grups de Recerca (SGR) URV-IISPV Finançament- Grup de Recerca Consolidat

    Funding entity: Agència de Gestió d’Ajuts Universitaris i de Recerca

    Duration: 2017 – 2021

    Principal Investigator: Joaquín Escribano Subias

  • Project title: ECHOES: Epigenetic and metabolic alterations associated to early childhood exposure to air pollution and its role in later life chronic disease

    IP: Noelia Ramírez González

    Funding agency: Fundació “La Caixa”

    Financing (in thousands of euros): 98.450,00 €

    Duration (financing period): 01/02/2020 – 31/01/2022

    Project reference: LCF/PR/SR19/52540002

  • Project title: Double-blind, randomized placebo-controlled trial investigating the effect of prebiotic Oligofructose-enriched Inulin Orafti®Synergy1 on bowel habits of infants six to twelve months of age (PETIT)

    IP: Joaquín Escribano Subias

    Funding agency: Beneo GmbH (Industria Privada)

    Financing (in thousands of euros): 364.400,00 €

    Duration (financing period): 29/10/2020 – 30/10/2022

    Project reference: PETIT

  • Project title: Electroencefalografia con integracion de amplitud (aeeg): analisis comparativo entre los electrodos de gel liquido y un nuevo electrodo de copa, advanced cup electro de acup-e con codigo de protocolo (acup-e) edp Salut Sant Joan De Reus

    IP: Joaquín Escribano Subias

    Funding agency: BAIX CAMP

    Duration (financing period): 26/01/2022- 25/11/2022

  • Project title: Efecto de una intervención motivacional sobre la microbiota intestinal y los componentes del síndrome metabólico en una población obesa pediátrica (Microbekids)

    IP: Verónica Luque Moreno, Ricardo Closa Monasterolo

    Funding agency: Instituto de Salud Carlos IIII

    Financing (in thousands of euros): 108.900.00 €

    Duration (financing period):01/01/2019 – 31/12/2022

    Project reference: PI18/00226

  • Project title: Caracterización de la enfermedad celíaca no HLA-DQ2.5

    IP: María Concepción Núñez Pardo de Vera

    Funding agency: Associación de Celíacos de la Comunidad de Madrid

    Financing (in thousands of euros): 18.000,00 €

    Duration (financing period): 01/01/2022 – 31/12/2023

    Project reference: XVIII Premio de investigación básica y aplicada sobre la sensibilidad al gluten

  • Project title: ATMOS: Wearable personal sampler to monitor exposure to atmospheric toxicants

    IP: Noelia Ramirez

    Funding agency: CERCA: Centres de Recerca de Catalunya

    Financing (in thousands of euros): 9.800 €

    Duration (financing period): 01/03/2023 – 28/02/2024

    Project reference: 2022-11-009

  • Project title: First 1000 days strategies to prevent childhood obesity (EndObesity)

    IP: Joaquin Escribano Subias

    Funding agency: HDHL- Intimic. A traves de l’Agencia Estatal de Investigación

    Financing (in thousands of euros): 100.000,00 €

    Duration (financing period): 01/04/2021 – 01/04/2024

    Project reference: PCI2020-120697-2

  • Project title: INVESTIGO AGAUR” PEROSNAL TECNOLEG

    IP: Joaquín Escribano Subias

    Funding agency: AGENCIA DE GESTIO D’AJUTS UNIVERSITARIS

    Financing (in thousands of euros): 66.217 €

    Duration (financing period): 30/11/2022- 30/11/2024

    Project reference: 100036TG2

  • Project title: Enfoque multifactorial frente al diagnóstico del amplio espectro de la enfermedad celíaca

    IP: María Concepción Núñez Pardo de Vera

    Funding agency: Instituto de Salud Carlos IIII

    Financing (in thousands of euros): 118.580,00 €

    Duration (financing period): 01/01/2022 – 31/12/2024

    Project reference: PI21/00271

  • Project title: Effects of milk protein intake in young children on early growth and later obesity risk: a multicentre randomized clinical trial (TOMI)

    IP: Joaquín Escribano Subias

    Funding agency: Nestec Ltd.

    Financing (in thousands of euros): 2.637.439,00 €

    Duration (financing period): 28/12/2015 – 31/12/2024

  • Project title: OnBREATHE: Monitorización personal de la calidad del aire y digitalización de datos para el seguimiento de enfermedades crónicas respiratorias

    IP: Noelia Ramírez González

    Funding agency: Instituto de Salud Carlos III

    Financing (in thousands of euros): 400.510 €

    Duration (financing period): 31/12/2022- 30/12/2024

    Project reference: PMPTA22/00028

  • Project title: Biomarker signatures of diet, physical activity and sleep in children and youth (Biomarkids)

    IP: Joaquin Escribano Subias

    Funding agency: PI – HDHL -healthy diet for healthy life. A través del Instituto de Salud Carlos III

    Financing (in thousands of euros): 180.532,00 €

    Duration (financing period): 01/04/2022 – 01/04/2025

    Project reference: AC21_2/00010

  • Project title: EXPOSOME: Identificando el metaboloma de la obesidad infantil y la correlación con el exposoma personal

    IP: Noelia Ramírez González and Joaquin Escribano Subias

    Funding agency: Instituto de Salud Carlos III

    Financing (in thousands of euros): 98.615€

    Duration (financing period): 31/12/2022- 30/12/2025

    Project reference: PI22/00852

  • Project title: Caracterización de la exposición individual a contaminación atmosférica en pacientes pediátricos con asma

    IP: Maria Teresa Pascual

    Funding agency: Sociedad Española de Nuemología Pediátrica

    Financing (in thousands of euros): 15.000 €

    Duration (financing period): 01/06/2024 – 30/05/2026

  • Project title: EXPOCARDI: Exposoma Químic i factors de risc Cardiometabòlics en Infants

    IP: Nancy Babio-Noelia Ramirez

    Funding agency: Fundació Acadèmia de Ciències Mèdiques i de la Salut de Catalunya i de Balears

    Financing (in thousands of euros): 30.000 €

    Duration (financing period): 01/06/2024 – 30/05/2026

  • Project title: Effects of infant feeding with goat milk formula or cow milk formula on eczema (GIRAFFE)

    IP: Joaquín Escribano Subias

    Funding agency: DAIRY GOAT CO-OPERATIVE (N.Z.) LIMITED

    Financing (in thousands of euros): 850.438,00 €

    Duration (financing period): 09/11/2020 – 31/12/2026

    Project reference: DGC201911

  • Project title: Ajut predoctoral PFIS

    IP: Joaquin Escribano Subias

    Funding agency: Instituto de Salud Carlos III

    Financing (in thousands of euros): 89.900 €

    Duration (financing period): 30/09/2023-29/09/2027

    Project reference: FI22/00166-IISPV

  • Project title: Ajut predoctoral PFIS

    IP: Noelia Ramírez González

    Funding agency: Instituto de Salud Carlos III

    Financing (in thousands of euros): 89.900 €

    Duration (financing period): 01/01/2024-31/12/2027

    Project reference: FI23/00032-IISPV

  • Project title: Effects of intant feeding with goat milk formula or cow milk formula on atopic dermatitis (the giraffe study)

    IP: Joaquín Escribano Subias

    Funding agency: Ajuntament d’Alforja

    Financing (in thousands of euros): 799.438 €

    Duration (financing period): 08/11/2020-30/06/2028

  • Project title: Parc: partnership for the assessment of risks from chemicals

    IP: Vikas Kumar

    Collaborator: Noelia Ramírez

    Funding agency: European Commission

    Financing (in thousands of euros): 2.500.000 €

    Duration (financing period): 01/05/2022 – 30/04/2029

    Project reference: HORIZON-HLTH-2021-ENVHLTH-03-101057014

  • Project title: Estudio observacional, prospectivo y multicéntrico a largo plazo en una cohorte de niños con talla baja nacidos pequeños para su edad gestacional (PEG) que han sido tratados con Saizen® (SALTO)

    IP: Albert Feliu Rovira

    Funding agency: Merck KFaA, Germany. Merck, S.L, España

    Financing (in thousands of euros):

    Duration (financing period): 2016 – Active

    Project reference: EMR 200098_008

  • Project title: Global patient registry to monitor long-term safety and effectiveness of Increlex® in children and adolescents with severe primary insulina-like-growth factor 1 deficiency (SPIGFD)

    IP: Albert Feliu Rovira

    Funding agency:

    Financing (in thousands of euros):

    Duration (financing period): 15/05/2019 – Active

    Project reference: 2-79-52800-002. NCT00903110

  • Project title: Estudio epidemiológico de las infecciones respiratorias por el nuevo Coronavirus (SARS-CoV2) en población pediátrica. EPICO

    IP: Neus Rius Gordillo

    Funding agency: Instituto de Investigación del Hospital 12 de Octubre i+12 y la Asociación Española de Pediatría (AEP)

    Financing (in thousands of euros):

    Duration (financing period): 2020 – Active

    Project reference: 20/101

  • Project title: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of PRV-015 in Adult Patients with Non-Responsive Celiac Disease as an Adjunct to a Gluten-free Diet.

    IP: Gemma Castillejo de Villasante

    Funding agency: Provention Bio, Inc

    Financing (in thousands of euros):

    Duration (financing period): 06/04/2021 – Active

    Project reference: EudraCT: 2020-000649-16

  • Title: Motivational Therapy for the Treatment of Childhood Obesity
    I-Depot number: 119460
    Authors: Feliu Rovira, A; Luque Moreno, V; Escribano Subías, J; Closa Monasterolo, R; Ferré Pallàs; Guillen Rey, N
    Institutions: IISPV, URV

  • Title: Motivational Approach to Treat Childhood Obesity (OBEMAT20) MAT
    I-Depot number: 119353
    Authors: Luque Moreno, V; Feliu Rovira, A; Guillen Rey, N; Gutiérrez Marin, D; Escribano Subías, J; Closa Monasterolo, R; Ferré Pallàs, N; Cabré Ambròs, J
    Institutions: IISPV, URV

  • Guies de pràctica clínica
    Investigador principal: JOAQUÍN ESCRIBANO»
    «Línia: COMPOSICIÓ CORPORAL

    Mental performance in 8-year-old children fed reduced protein content formula during the 1st year of life: safety analysis of a randomised clinical trial

    Escribano J, Luque V, Canals-Sans J, Ferré N, Koletzko B, Grote V, Weber M, Gruszfeld D, Szott K, Verduci E, Riva E, Brasselle G, Poncelet P,Closa-Monasterolo R; EU Childhood Obesity Project Group
    Br J Nutr

    DOI: 10.1017/S0007114515000768

    European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease

    Husby S, Koletzko S, Korponay-Szabó I, Kurppa K, Mearin ML, Ribes-Koninckx C, Shamir R, Troncone R, Auricchio R, Castillejo G, Christensen R, Dolinsek J, Gillett P, Hróbjartsson A, Koltai T, Maki M, Nielsen SM, Popp A, Størdal K, Werkstetter K, Wessels M.
    J Pediatr Gastroenterol Nutr

    DOI: 10.1097/MPG.0000000000002497

    Impact of infant protein supply and other early life factors on plasma metabolome at 5.5 and 8 years of age: a randomized trial

    Kirchberg FF, Hellmuth C, Totzauer M, Uhl O, Closa-Monasterolo R, Escribano J, Gruszfeld D, Gradowska K, Verduci E, Mariani B, Moretti M, Rousseaux D,Koletzko B; European Childhood Obesity Trial Study Group
    Int J Obes (Lond)

    DOI: 10.1038/s41366-019-0398-9

    Recommendations of the Spanish Society of Paediatric Cardiology and Congenital Heart Disease as regards the use of drugs in attention deficit hyperactivity disorder in children and adolescents with a known heart disease, as well as in the general paediatric population: Position statement by the Spanish Paediatric Association

    Pérez-Lescure Picarzo J, Centeno Malfaz F, Collell Hernández R, CrespoMarcos D, Fernández Soria T, Manso García B, Rojo Sombrero H, Sabaté Rotés A,Sarquella-Brugada G
    An Pediatr (Barc)

    DOI: 10.1016/j.anpedi.2019.09.002

    Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
    Zheng Y, Huang T, Wang T, Mei Z, Sun Z, Zhang T, Ellervik C, Chai JF, Sim X, van Dam RM, Tai ES, Koh WP, Dorajoo R, Saw SM, Sabanayagam C, Wong TY, Gupta P, Rossing P, Ahluwalia TS, Vinding RK, Bisgaard H, Bønnelykke K, Wang Y, Graff M, Voortman T, van Rooij FJA, Hofman A, van Heemst D, Noordam R, Estampador AC, Varga TV, Enzenbach C, Scholz M, Thiery J, Burkhardt R, Orho-Melander M, Schulz CA, Ericson U, Sonestedt E, Kubo M, Akiyama M, Zhou A, Kilpeläinen TO, Hansen T, Kleber ME, Delgado G, McCarthy M, Lemaitre RN, Felix JF, Jaddoe VWV, Wu Y, Mohlke KL, Lehtimäki T, Wang CA, Pennell CE, Schunkert H, Kessler T, Zeng L, Willenborg C, Peters A, Lieb W, Grote V, Rzehak P, Koletzko B, Erdmann J, Munz M, Wu T, He M, Yu C, Lecoeur C, Froguel P, Corella D, Moreno LA, Lai CQ, Pitkänen N, Boreham CA, Ridker PM, Rosendaal FR, de Mutsert R, Power C, Paternoster L, Sørensen TIA, Tjønneland A, Overvad K, Djousse L, Rivadeneira F, Lee NR, Raitakari OT, Kähönen M, Viikari J, Langhendries JP, Escribano J, Verduci E, Dedoussis G, König I, Balkau B, Coltell O, Dallongeville J, Meirhaeghe A, Amouyel P, Gottrand F, Pahkala K, Niinikoski H, Hyppönen E, März W, Mackey DA, Gruszfeld D, Tucker KL, Fumeron F, Estruch R, Ordovas JM, Arnett DK, Mook-Kanamori DO, Mozaffarian D, Psaty BM, North KE, Chasman DI, Qi L. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. Eur J Epidemiol. 2020 Jul;35(7):685-697. Epub 2020 May 7. PMID: 32383070; PMCID: PMC7867117.
    Associations of sugar intake with anthropometrics in children from ages 2 until 8 years in the EU Childhood Obesity Project

    Aumueller N, Gruszfeld D, Gradowska K, Escribano J, Ferré N, Rousseaux D, Hoyos J, Verduci E, ReDionigi A, Koletzko B, Grote V.
    Eur J Nutr. 2020 Sep;59(6):2593-2601.

    DOI: 10.1007/s00394-019-02107-0

    Commercial complementary food use amongst European infants and children: results from the EU Childhood Obesity Project

    Theurich MA, Zaragoza-Jordana M, Luque V, Gruszfeld D, Gradowska K, Xhonneux A, Riva E, Verduci E, Poncelet P, Damianidi L, Koletzko B, Grote V.
    Eur J Nutr.2020 Jun;59(4):1679-1692.

    DOI: 10.1007/s00394-019-02023-3

    Breast-Milk Microbiota Linked to Celiac Disease Development in Children: A Pilot Study From the PreventCD Cohort

    Benítez-Páez A, Olivares M, Szajewska H, Pieścik-Lech M, Polanco I, Castillejo G, Nuñez M, Ribes-Koninckx C, Korponay-Szabó IR, Koletzko S, Meijer CR, Mearin ML, Sanz Y. Front Microbiol. 2020 Jun 23;11:1335.

    DOI: 10.3389/fmicb.2020.01335

    DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

    Vehmeijer FOL, Küpers LK, Sharp GC, Salas LA, Lent S, Jima DD, Tindula G, Reese S, Qi C, Gruzieva O, Page C, Rezwan FI, Melton PE, Nohr E, Escaramís G, Rzehak P, Heiskala A, Gong T, Tuominen ST, Gao L, Ross JP, Starling AP, Holloway JW, Yousefi P, Aasvang GM, Beilin LJ, Bergström A, Binder E, Chatzi L, Corpeleijn E, Czamara D, Eskenazi B, Ewart S, Ferre N, Grote V, Gruszfeld D, Håberg SE, Hoyo C, Huen K, Karlsson R, Kull I, Langhendries JP, Lepeule J, Magnus MC, Maguire RL, Molloy PL, Monnereau C, Mori TA, Oken E, Räikkönen K, Rifas-Shiman S, Ruiz-Arenas C, Sebert S, Ullemar V, Verduci E, Vonk JM, Xu CJ, Yang IV, Zhang H, Zhang W, Karmaus W, Dabelea D, Muhlhausler BS, Breton CV, Lahti J, Almqvist C, Jarvelin MR, Koletzko B, Vrijheid M, Sørensen TIA, Huang RC, Arshad SH, Nystad W, Melén E, Koppelman GH, London SJ, Holland N, Bustamante M, Murphy SK, Hivert MF, Baccarelli A, Relton CL, Snieder H, Jaddoe VWV, Felix JF.
    Genome Med. 2020 Nov 25;12(1):105.

    DOI: 10.1186/s13073-020-00810-w

    Fibre Intake Is Associated with Cardiovascular Health in European Children

    Larrosa S, Luque V, Grote V, Closa-Monasterolo R, Ferré N, Koletzko B, Verduci E, Gruszfeld D, Xhonneux A, Escribano J.
    Nutrients. 2020 Dec 23;13(1):12.

    DOI: 10.3390/nu13010012

    An Infant Formula with Partially Hydrolyzed Whey Protein Supports Adequate Growth and Is Safe and Well-Tolerated in Healthy, Term Infants: A Randomized, Double-Blind, Equivalence Trial

    Picaud JC, Pajek B, Arciszewska M, Tarczón I, Escribano J, Porcel R, Adelt T, Hassink E, Rijnierse A, Abrahamse-Berkeveld M, Korczowski B, On Behalf Of The Tenuto Study Group.
    Nutrients. 2020 Jul 13;12(7):2072

    DOI: 10.3390/nu12072072

    Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, Heiskala A, Horikoshi M, Fedko IO, Vilor-Tejedor N, Cousminer DL, Standl M, Wang CA, Viikari J, Geller F, Íñiguez C, Pitkänen N, Chesi A, Bacelis J, Yengo L, Torrent M, Ntalla I, Helgeland Ø, Selzam S, Vonk JM, Zafarmand MH, Heude B, Farooqi IS, Alyass A, Beaumont RN, Have CT, Rzehak P, Bilbao JR, Schnurr TM, Barroso I, Bønnelykke K, Beilin LJ, Carstensen L, Charles MA, Chawes B, Clément K, Closa-Monasterolo R, Custovic A, Eriksson JG, Escribano J, Groen-Blokhuis M, Grote V, Gruszfeld D, Hakonarson H, Hansen T, Hattersley AT, Hollensted M, Hottenga JJ, Hyppönen E, Johansson S, Joro R, Kähönen M, Karhunen V, Kiess W, Knight BA, Koletzko B, Kühnapfel A, Landgraf K, Langhendries JP, Lehtimäki T, Leinonen JT, Li A, Lindi V, Lowry E, Bustamante M, Medina-Gomez C, Melbye M, Michaelsen KF, Morgen CS, Mori TA, Nielsen TRH, Niinikoski H, Oldehinkel AJ, Pahkala K, Panoutsopoulou K, Pedersen O, Pennell CE, Power C, Reijneveld SA, Rivadeneira F, Simpson A, Sly PD, Stokholm J, Teo KK, Thiering E, Timpson NJ, Uitterlinden AG, van Beijsterveldt CEM, van Schaik BDC, Vaudel M, Verduci E, et al.
    PLoS Genet. 2020 Oct 12;16(10):e1008718.

    DOI: 10.1371/journal.pgen.1008718

    Effects of screen time and playing outside on anthropometric measures in preschool aged children

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R, Rousseaux D, Moretti M, ReDionigi A, Verduci E, Koletzko B, Grote V.
    PLoS One. 2020 Mar 2;15(3):e0229708.

    DOI: 10.1371/journal.pone.0229708

    An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children

    Hellmuth C, Kirchberg FF, Brandt S, Moß A, Walter V, Rothenbacher D, BrennerH, Grote V, Gruszfeld D, Socha P, Closa-Monasterolo R, Escribano J, Luque V,Verduci E, Mariani B, Langhendries JP, Poncelet P, Heinrich J, Lehmann I, Standl M, Uhl O, Koletzko B, Thiering E, Wabitsch M
    Sci Rep

    DOI: 10.1038/s41598-019-41449-x

    Are all breast-fed infants equal? Clustering metabolomics data to identify predictive risk clusters for childhood obesity

    Kirchberg FF, Grote V, Gruszfeld D, Socha P, Closa-Monasterolo R, Escribano J, Verduci E, Mariani B, Langhendries JP, Poncelet P, Koletzko B, Hellmuth C;European Childhood Obesity Trial Study Group
    J Pediatr Gastroenterol Nutr

    DOI: 10.1097/MPG.0000000000002184

    Association of birth weight with type 2 diabetes and glycemic traits: A mendelian randomization study

    BIRTH-GENE (BIG) Study Working Group, Huang T, Wang T, Zheng Y, Ellervik C, Li X, Gao M, Fang Z, Chai JF, Ahluwalia TVS, Wang Y, Voortman T, Noordam R,Frazier-Wood A, Scholz M, Sonestedt E, Akiyama M, Dorajoo R, Zhou A, Kilpeläinen TO, Kleber ME, Crozier SR, Godfrey KM, Lemaitre R, Felix JF, Shi Y, Gupta P, KhorCC, Lehtimäki T, Wang CA, Tiesler CMT, Thiering E, Standl M, Rzehak P, Marouli E,He M, Lecoeur C, Corella D, Lai CQ, Moreno LA, Pitkänen N, Boreham CA, Zhang T,Saw SM, Ridker PM, Graff M, van Rooij FJA, Uitterlinden AG, Hofman A, van Heemst D, Rosendaal FR, de Mutsert R, Burkhardt R, Schulz CA, Ericson U, Kamatani Y,Yuan JM, Power C, Hansen T, Sørensen TIA, Tjønneland A, Overvad K, Delgado G,Cooper C, Djousse L, Rivadeneira F, Jameson K, Zhao W, Liu J, Lee NR, RaitakariO, Kähönen M, Viikari J, Grote V, Langhendries JP, Koletzko B, Escribano J,Verduci E, Dedoussis G, Yu C, Tham YC, Lim B, Lim SH, Froguel P, Balkau B, FinkNR, Vinding RK, Sevelsted A, Bisgaard H, Coltell O, Dallongeville J, Gottrand F, Pahkala K, Niinikoski H, Hyppönen E, Pedersen O, März W, Inskip H, Jaddoe VWV,Dennison E, Wong TY, Sabanayagam C, Tai ES, Mohlke KL, Mackey DA, Gruszfeld D,Deloukas P, Tucker KL, Fumeron F, Bønnelykke K, Rossing P, Estruch R, Ordovas JM,Arnett DK, Meirhaeghe A, Amouyel P, Cheng CY, Sim X, Teo YY, van Dam RM, Koh WP, Orho-Melander M, Loeffler M, Kubo M, Thiery J, Mook-Kanamori DO, Mozaffarian D,Psaty BM, Franco OH, Wu T, North KE, Davey Smith G, Chavarro JE, Chasman DI, QiL
    JAMA Netw Open

    DOI: 10.1001/jamanetworkopen.2019.10915

    Associations of age and body mass index with hydration and density of fat-free mass from 4 to 22 years

    Gutiérrez-Marín D, Luque V, Ferré N, Fewtrell MS, Williams JE, Wells JCK
    Eur J Clin Nutr

    DOI: 10.1038/s41430-019-0447-4

    Associations of sugar intake with anthropometrics in children from ages 2 until 8 years in the EU Childhood Obesity Project

    Aumueller N, Gruszfeld D, Gradowska K, Escribano J, Ferré N, Rousseaux D,Hoyos J, Verduci E, ReDionigi A, Koletzko B, Grote V
    Eur J Nutr

    DOI: 10.1007/s00394-019-02107-0

    Cardiopulmonary resuscitation in newborn infants with ultrasound in the delivery room.

    Rodriguez-Fanjul J, Perez-Baena L, Perez A.
    J Matern Fetal Neonatal Med.

    DOI: 10.1080/14767058.2019.1661379

    Chest ultrasound for diagnosis of transfusion-related acute lung injury.

    Rosich Del Cacho B, Sorribes Ortiz CA, Rodríguez-Fanjul J.
    Med Intensiva.

    DOI: 10.1016/j.medin.2019.07.002

    Commercial complementary food use amongst European infants and children: results from the EU Childhood Obesity Project

    Theurich MA, Zaragoza-Jordana M, Luque V, Gruszfeld D, Gradowska K, XhonneuxA, Riva E, Verduci E, Poncelet P, Damianidi L, Koletzko B, Grote V
    Eur J Nutr

    DOI: 10.1007/s00394-019-02023-3

    Correction to: Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R,Rousseaux D, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Int J Behav Nutr Phys Act

    DOI: 10.1186/s12966-019-0785-6

    Correction to: Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years.

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R, Rousseaux D, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Int J Behav Nutr Phys Act

    DOI: 10.1186/s12966-019-0785-6

    Cultural effects on neurodevelopmental testing in children from six European countries: an analysisof NUTRIMENTHE Global Database

    Pérez-García M, Luna JD, Torres-Espínola FJ, Martínez-Zaldívar C, Anjos T,Steenweg-de Graaff J, Weber M, Grote V, Gruszfeld D, Verduci E, Poncelet P,Escribano J, Tiemeier H, Koletzko B, Campoy C
    Br J Nutr

    DOI: 10.1017/S0007114517000824

    Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial

    Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C,Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V
    BMC Pediatr

    DOI: 10.1186/s12887-019-1679-0

    European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders

    Al-Toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, MulderCJ, Lundin KEA
    United EuropeanGastroenterol J

    DOI: 10.1177/2050640619844125

    Lung ultrasound in children: What does it give us?

    Bobillo-Perez S, Girona-Alarcon M, Rodriguez-Fanjul J, Jordan I, Balaguer
    Gargallo M.
    Paediatr Respir Rev.

    DOI: 10.1016/j.prrv.2019.09.006

    Lung ultrasound in the follow-up of primary ciliary dyskinesia.

    Guitart C, Del Rey Hurtado de Mendoza B, Camprubi Camprubi M, Rodriguez-Fanjul J.
    J Matern Fetal Neonatal Med.

    DOI: 10.1080/14767058.2019.1636027

    Lung Ultrasound to Assess the Etiology of Persistent Pulmonary Hypertension of the Newborn (LUPPHYN Study): A Pilot Study.

    Del Rey Hurtado de Mendoza B, Sánchez-de-Toledo J, Bobillo Perez S, Girona M, Balaguer Gargallo M, Rodríguez-Fanjul J.
    Neonatology

    DOI: 10.1159/000499047

    Neonatal Marfan Syndrome: A Rare, Severe, and Life-Threatening Genetic Disease.

    Solé-Ribalta A, Rodríguez-Fanjul X, Carretero-Bellon JM, Pascual-Sala C, Martorell-Sampol L, Bobillo-Pérez S, Morillo-Palomo AM.
    J Pediatr.

    DOI: 10.1016/j.jpeds.2019.03.033

    Nutritionduring pregnancy, lactation and early childhood and its implications for maternal and long-term child health: The Early Nutrition Project recommendations.

    Koletzko B, Godfrey KM, Poston L, Szajewska H, van Goudoever JB, de Waard M, Brands B, Grivell RM, Deussen AR, Dodd JM, Patro-Golab B, Zalewski BM; EarlyNutrition Project Systematic Review Group
    Ann Nutr Metab

    DOI: 10.1159/000496471

    Physical activity and sedentary behavior from 6 to 11 years

    Schwarzfischer P, Gruszfeld D, Stolarczyk A, Ferre N, Escribano J, RousseauxD, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Pediatrics

    DOI: 10.1542/peds.2018-0994

    Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet.

    Comino I, Segura V, Ortigosa L, Espín B, Castillejo G, Garrote JA, Sierra C, Millán A, Ribes-Koninckx C, Román E, Rodríguez-Herrera A, Díaz J, Silvester JA, Cebolla Á, Sousa C.
    Aliment Pharmacol Ther

    DOI: 10.1111/apt.15277

    Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus.

    Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J, Kurepa D, Feng X, Cattaross L, Zhang H, Hwang M, Yeh TF, Lipener Y, Lodha A, Wang JQ, Cao HY, Hu CB, Lyu GR, Qiu XR, Jia LQ, Wang XM, Ren XL, Guo JY, Gao YQ, Li JJ, Liu Y, Fu W, Wang Y, Lu ZL, Wang HW, Shang LL.
    J Vis Exp.

    DOI: 10.3791/58990

    Refractory Cardiogenic Shock due to Enterovirus Myocarditis: Experience at one Institution.

    Bobillo-Perez S, Sanchez-de-Toledo J, Matute SS, Balaguer M, Jordan I, Rodriguez-Fanjul J.
    Med Intensiva.

    DOI: 10.1016/j.medin.2019.03.006

    Should abdominal ultrasound be the first image choice test in necrotizing enterocolitis?

    Batista Muñoz A, Otero Vaccarello O, Rodriguez-Fanjul J
    Med Intensiva.

    DOI: 10.1016/j.medin.2019.09.014

    The Obemat2.0 Study: A clinical trial of a motivational intervention for childhood obesity treatment

    Luque V, Feliu A, Escribano J, Ferré N, Flores G, Monné R, Gutiérrez-MarínD, Guillen N, Muñoz-Hernando J, Zaragoza-Jordana M, Gispert-Llauradó M,Rubio-Torrents C, Núñez-Roig M, Alcázar M, Ferré R, Basora JM, Hsu P,Alegret-Basora C, Arasa F, Venables M, Singh P, Closa-Monasterolo R
    Nutrients

    DOI: 10.3390/nu11020419

    Ultrasound-guided recruitment maneuvers in pediatric acute chest syndrome due to sickle cell disease.

    Bobillo-Perez S, Rodriguez-Fanjul J, Girona-Alarcon M, Cambra FJ, Jordan I, Balaguer M.
    Med Intensiva.

    DOI: 10.1016/j.medin.2019.06.002

    Variation and interdependencies of human milk macronutrients, fatty acids, adiponectin, insulin, and IGF-II in the European Prevent CD Cohort

    Grunewald M, Hellmuth C, Kirchberg FF, Mearin ML, Auricchio R, Castillejo G,Korponay-Szabo IR, Polanco I, Roca M, Vriezinga SL, Werkstetter K, Koletzko B,Demmelmair H
    Nutrients

    DOI: 10.3390/nu11092034

    Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years.

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R, Rousseaux D, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Int J Behav Nutr Phys Act

    DOI: 10.1186/s12966-018-0756-3

Miembros Del equipo

  • Responsable de grupo

    • Dr. Joaquín Escribano Subias
  • Investigador/a Senior

    • Natàlia Ferré Pallàs
    • Verònica Luque Moreno
    • Noelia Ramírez González
  • Investigador/a Senior clínico

    • Elisabet Camprubí Tubella
    • Gemma Castillejo de Villasante
    • Rosa Collell Hernández
    • Albert Feliu Rovira
    • Esther Parada Ricart
  • Investigador/a Postdoctoral

    • Mariona Gispert Llauradó
    • Judit Muñoz Hernando
    • Mireia Alcázar López
    • Mahsa Naghavi Sheikholeslami
    • María del Carmen Rubio Torrents
  • Investigador/a Postdoctoral clínico

    • Neus Rius Gordillo
    • Susana Larrosa Capaces
  • Doctorantes

    • Irina Gheorghita
    • Irene Hernández
    • Camilla Guerrini
    • María Hernández Herrero
  • Investigadores eméritos

    • Ricardo Closa Monasterolo