El Grupo de Investigación en Oncología de cabeza y cuello pretende avanzar en el conocimiento de las enfermedades tumorales de esta área anatómica que comprende el cuello, la boca, la lengua, la faringe, la laringe, las fosas nasales y las glándulas salivales, ya sea a nivel molecular, traslacional, clínico, así como de desarrollo de técnicas y dispositivos quirúrgicos. Nuestra visión es dar respuesta a las cuestiones que se plantean cuando estamos ante los pacientes, por este motivo los médicos que trabajan en el hospital trabajan con investigadores básicos. La complejidad, la referencia, la investigación y la docencia son la base de este grupo de investigación.

• Factores pronósticos derivados del metabolismo del cáncer de cabeza y cuello
• Abordajes quirúrgicos mínimamente invasivos
• Caracterización multiómica del cáncer de cabeza y cuello
• Introducción de biopsias en matrices mínimamente invasivas

1. Caracterización multiómica del carcinoma escamoso de cabeza y cuello mediante biopsia gaseosa y líquida: aplicación diagnóstica, pronóstica y de seguimiento. HN-OMICS. Proyectos de investigación de medicina personalizada. Ministerio Ciencia e Innovación. Grupo coordinador.2023-2026. 929.500eur
2. Microbiota tumor metabolic regulation as prognostic factors in HNSCC. Entitat finançadora: AECC-Asociación española contra el cáncer: 253.000 eur. 2019-2022
3. Microbiota y alteraciones metabólicas como factor pronóstico en el carcinoma escamoso de cabeza y cuello. FIS PI18/00844ISC3 – Instituto de Salud Carlos III 111.320 eur. 2019-2021
4. Impacto clínico del metabolismo de la glucosa en el carcinoma escamoso de cabeza y cuello. FIS PI15/02047. Instituto de Salud Carlos III. 75.000eur
5. Grup recerca emergent Head Neck Clínic. Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR): 2017 SGR 5081. 9.950eur. 2017-2021

Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. Bagué S, León X, Terra X, Lejeune  , Camacho M, Avilés-Jurado FX. Head Neck. 2022 Nov;44(11):2505-2512. doi:  10.1002/hed.27161. Epub 2022 Aug 4. PMID: 36207788

Sinonasal mucosal melanomas: defining profiles for better survival outcomes. Rojas-Lechuga MJ, Gras-Cabrerizo JR, Aviles-Jurado FX, Malvehy J, Arance AM, Castillo P, Barreiro A, Podlipnik S, Lopez-Chacon M, Alobid I, Bernal Sprekelsen M, Puig S, Langdon C. Rhinology. 2022 Oct 1;60(5):347-356. doi: 10.4193/Rhin21.251. PMID: 36184882

Persistent lymph nodes after curative chemoradiotherapy for head and neck cancer: imaging predictors of response for decision-making. Páez-Carpio A, Medrano-Martorell S, Berenguer J, Muxí A, Vilaseca I, Valduvieco I, Castillo P, Baste N, Avilés-Jurado FX, Grau JJ, Oleaga L. Eur Arch Otorhinolaryngol. 2022 Oct 1. doi: 10.1007/s00405-022-07658-3. Online ahead of print. PMID: 36181529

Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. Meler-Claramonte C, Avilés-Jurado FX, Vilaseca I, Terra X, Bragado P, Fuster G, León Vintró X, Camacho M. Cancers (Basel). 2022 Apr 30;14(9):2259. doi: 10.3390/cancers14092259. PMID: 35565388 Free PMC article.

Predictive capacity of IL-8 expression in head and neck squamous carcinoma patients treated with radiotherapy or chemoradiotherapy.  León X, García J, Farré N, Majercakova K, Avilés-Jurado FX, Quer M, Camacho M. Acta Otorrinolaringol Esp (Engl Ed). 2021 Nov-Dec;72(6):337-343. doi: 10.1016/j.otoeng.2020.05.006. PMID: 34844671

Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Vilaseca I, Aviles-Jurado FX, Valduvieco I, Berenguer J, Grau JJ, Baste N, Muxí Á, Castillo P, Lehrer E, Jordana M, Ramírez-Ruiz RD, Costa JM, Oleaga L, Bernal-Sprekelsen M. Head Neck. 2021 Dec;43(12):3832-3842. doi: 10.1002/hed.26878. Epub 2021 Sep 27. PMID: 34569120

Timing of elective tracheotomy and duration of mechanical ventilation among patients admitted to intensive care with severe COVID-19: A multicenter prospective cohort study. Prats-Uribe A, Tobed M, Villacampa JM, Agüero A, García-Bastida C, Tato JI, Rodrigáñez L, Holguera VD, Hernández-García E, Poletti D, Simonetti G, Villarraga V, Meler-Claramonte C, Sánchez Barrueco Á, Chiesa-Estomba C, Casasayas M, Parente-Arias P, Mata-Castro N, Rello J, Castro P, Prieto-Alhambra D, Vilaseca I, Avilés-Jurado FX; TraqueoCOVID SEORL Group. Head Neck. 2021 Dec;43(12):3743-3756. PMID: 34524714

Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker. Terra X, Ceperuelo-Mallafré V, Merma C, Benaiges E, Bosch R, Castillo P, Flores JC, León X, Valduvieco I, Basté N, Cámara M, Lejeune M, Gumà J, Vendrell J, Vilaseca I, Fernández-Veledo S, Avilés-Jurado FX. Cancers (Basel). 2021;13:1653. PMID: 33916314

Measuring Tracheotomy Risk in Patients with COVID-19-Time to Look Beyond Surgery and Surgeons-Reply. Avilés-Jurado FX, Vilaseca I. JAMA Otolaryngol Head Neck Surg. 2021 Jul 1;147(7):679-680. doi: 10.1001/jamaoto.2021.0552. PMID: 33885721

Timing, Complications, and Safety of Tracheotomy in Critically Ill Patients with COVID-19. Avilés-Jurado FX, Prieto-Alhambra D, González-Sánchez N, de Ossó J, Arancibia C, Rojas-Lechuga MJ, Ruiz-Sevilla L, Remacha J, Sánchez I, Lehrer-Coriat E, López-Chacón M, Langdon C, Guilemany JM, Larrosa F, Alobid I, Bernal-Sprekelsen M, Castro P, Vilaseca I. JAMA Otolaryngol Head Neck Surg. 2020;147:1-8.

Transoral laser microsurgery in locally advanced laryngeal cancer: Prognostic impact of anterior versus posterior compartments. Vilaseca I, Aviles-Jurado FX, Valduvieco I, Berenguer J, Grau JJ, Baste N, Muxí Á, Castillo P, Lehrer E, Jordana M, Ramírez-Ruiz RD, Costa JM, Oleaga L, Bernal-Sprekelsen M. Head Neck. 2021;43:3832-3842. PMID: 34569120

The aspartate aminotransaminase/alanine aminotransaminase (De Ritis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients. Sansa A, Venegas MDP, Valero C, Pardo L, Avilés-Jurado FX, Terra X, Quer M, León X. Head Neck. 2021 ;43:2091-2100. PMID: 3367509

Predictive capacity of IL-8 expression in head and neck squamous carcinoma patients treated with radiotherapy or chemoradiotherapy. León X, García J, Farré N, Majercakova K, Avilés-Jurado FX, Quer M, Camacho M. Acta Otorrinolaringol Esp (Engl Ed). 2020 Sep 21:S0001-6519(20)30146-1. PMID: 32972719

Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain. Martin-Villares C, Perez Molina-Ramirez C, Bartolome-Benito M, Bernal-Sprekelsen M; COVID ORL ESP Collaborative Group (*). Eur Arch Otorhinolaryngol. 2021;278:1605-1612. PMID: 32749607

Transoral reconstruction of oropharyngeal tumors. The Hospital Clínic algorithm. Avilés-Jurado FX, Vilaseca I. JPRAS Open. 2020 Mar 21;24:25-31.. PMID: 32300634

Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. Avilés-Jurado FX, Muñoz C, Meler C, Flores JC, Gumà J, Benaiges E, Mora J, Camacho M, León X, Vilaseca I, Terra X. Eur Arch Otorhinolaryngol. 2021 May;278(5):1585-1594. PMID: 32737645

Prognostic relevance of insulin resistance on disease-free survival in head and neck squamous cell carcinomas: Preliminary results. Avilés-Jurado FX; Flores JC; Gumà J; Ceperuelo-Mallafré V; Casanova-Marqués R; Gómez D et al. Títol: Head and Neck. 2017;39:2501-2511.  Corresponding author.  PMID 28963801. IF 2.471 Àrea i posició dins d’ella: otorhinolaryngology, 9/41. Science Citation Index (SCI)

Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis Rodríguez, A.H.; Avilés-Jurado, F.X.; Díaz, E.; Schuetz, P.; Trefler, S.I.; Solé-Violán, J.; Cordero, L et al.. Journal of Infection 2016;72:143-151. PMID 26702737 IF 4.201  Infectious diseases, 16/84. Science Citation Index (SCI)

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma. Terra X, Gómez D, García-Lorenzo J, Flores JC, Figuerola E, Mora J, Chacón MR, Quer M, Camacho M, León X, Avilés-Jurado FX. Head and Neck. 2016;38:1358-1363  Corresponding author. IF 3.376 Àrea i posició dins d’ella: otorhinolaryngology, 1/43. Science Citation Index (SCI)

Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer Avilés-Jurado FX; Terra X; Gómez D;  Flores JC; Raventós A; Maymó E et al.. Eur Arch Oto-Rhino-Laryngol 2015;272:1733-1741 Corresponding author. PMID 24858806. IF 1.545 Àrea i posició dins d’ella: Otorhinolaryngology 18/43. Science Citation Index (SCI)

Prognostic factors in head and neck squamous cell carcinoma: Comparison of CHAID decision trees technology and cox analysis Avilés-Jurado, F.X.; León, X. Head and Neck. 2013;35:877-883  Corresponding author. IF 3.006 Àrea i posició dins d’ella: otorhinolaryngology, 1/ 43. Science Citation Index (SCI)

Overexpression of the nuclear factor-kappa B (p65) in association with local failure in patients with head and neck carcinoma undergong radiotherapy or chemoradiotherapy. Quintana, A.; Avilés, F.X.; Terra, X.; Alcolea, S.; Camacho, M.; Quer, M.; Vila, L.; León, X. Head and Neck. 2013;35:370-375  PMID 22422610 IF 3.006 Àrea i posició dins d’ella: otorhinolaryngology, 1/ 43. Science Citation Index (SCI)

Comparison of Chi Squared Automatic Interaction Detection Classification Trees vs TNM Classification for Patients with Head and Neck Squamous Cell Carcinoma Avilés-Jurado, F.X; Terra, X.; Figuerola, E.; Quer, M.; León, X. JAMA Archives of Otolaryngology-Head & Neck Surgery. 2012;138:272-279. Corresponding autor. PMID 22431872 IF 3.5. otorhinolaryngology 2/ 41. Science Citation Index (SCI)

Consensus document of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC), the Spanish Society of Otorhinolaryngology and Head and Neck Surgery (SEORL-CCC) and the Spanish Society of Anesthesiology and Resuscitation (SEDAR) on tracheotomy in patients with COVID-19 infection. Martín Delgado MC, Avilés-Jurado FX, Álvarez Escudero J, Aldecoa Álvarez-Santuyano C, de Haro López C, Díaz de Cerio Canduela P, Ferrandis Perepérez E, Ferrando Ortolá C, Ferrer Roca R, Hernández Tejedor A, López Álvarez F, Monedero Rodríguez P, Ortiz Suñer A, Parente Arias P, Planas Roca A, Plaza Mayor G, Rascado Sedes P, Sistiaga Suárez JA, Vera Ching C, Villalonga Vadell R, Bernal-Sprekelsen M. Med Intensiva (Engl Ed). 2020;44:493-499.

Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision-tree analysis Vilaseca I, Nogués A, Avilés-Jurado FX, Berenguer J, Grau JJ, Verger E et al. Head Neck 2019;41:756-764. PMID 30521676. IF 3.376. Otorhinolaryngology, 1/42. Science Citation Index (SCI)

Intra and interobserver agreement of Narrow Band Imaging for the detection of head and neck tumors. Nogués-Sabaté A, Avilés-Jurado FX, Ruiz-Sevilla L, Lehrer E, Santamaría-Gadea A, Valls-Mateus M, Vilaseca I. Eur Arch Oto-Rhino-Laryngol. 2018;275:2349-2354. PMID 30019190. IF 1.545 Àrea i posició dins d’ella: Otorhinolaryngology 18/43. Science Citation Index (SCI)

Narrow band imaging for head and neck malignancies: Lessons learned from mistakes. Valls-Mateus M, Nogués-Sabaté A, Blanch JL, Bernal-Sprekelsen M, Avilés-Jurado FX, Vilaseca I. Head Neck. 2018;40:1164-1173. PMID 29385299. IF 3.376. Àrea i posició dins d’ella: Otorhinolaryngology, 1/43. Science Citation Index (SCI)

Prognostic value of CD45 transcriptional expression in head and neck cancer Camacho M, Agüero A, Sumarroca A, López L, Pavón MÁ, Avilés-Jurado FX, García J, Quer M, León X. Eur Arch Otorhinolaryngol. 2018;275:225-232. PMID  29177949 IF 1.545. Otorhinolaryngology 18/43. Science Citation Index (SCI).

Usefulness of office examination with narrow band imaging for the diagnosis of head and neck squamous cell carcinoma and follow-up of premalignant lesions. Vilaseca, I; Valls-Mateus, M; Nogues, A; Lehrer, E; Lopez-Chacon, M; Aviles-Jurado, FX; Blanch, JL; Bernal-Sprekelsen, M. Head & Neck 2017.39;1854-1863. IF 2.471. PMID: 28640478 Otorhinolaryngology 9/41. Science Citation Index (SCI)

Risk Factors for Noninvasive Ventilation Failure in Critically Ill Subjects With Confirmed Influenza Infection Rodríguez A, Ferri C, Martin-Loeches I, Díaz E, Masclans JR, Gordo F, Sole-Violán J, Bodí M, Avilés-Jurado FX, Trefler S et al.. Respir Care. 2017;62:1307-1315. IF: 0.751. PMID 28698265. Critical care 26/50. Science Citation Index (SCI)

Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy. Camacho, M., Piñeiro, Z., Alcolea, S., García, J., Balart, J., Terra, X., Avilés-Jurado, F.-X., Soler, M., Quer, M., León, X., Vila, L. Journal of Pathology 2015.235;125-135. IF 7.381 oncology, 18/213; pathology, 3/78. Science Citation Index (SCI)

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.Alcolea S, Antón R, Camacho M, Soler M, Alfranca A, Avilés-Jurado FX et al. J Lipid Res. 2012;53:630-42. PMID: 22308510.

Angioedema ACE inhibitor Avilés Jurado FX, Planas Real K, Tobed Secall M, Doménech Vadillo E, Pobo Peris A, Figuerola Massana E.. Med Clin (Barc). 2010;134:664. IF 1.231. Medicine general and internal Q3. PMID: 19712942 Science Citation Index (SCI)