The Research Group on Oncological Pathology and Bioinformatics (PO&B) is a specific platform for research activities focused on cancer and digital image analysis and mathematical modeling.
Marylène Lejeune
Carlos López Pablo
The PO&B team of the IISPV, based at the Hospital de Tortosa Verge de la Cinta, has been working for more than 15 years on the prevention and advanced diagnosis of cancer. Led by Dra. Marylène Lejeune and Dr. Carlos López, the PO&B team is an interdisciplinary group that includes pathologists, oncologists, hematologists, biologists, and computer specialists, with strategic clinical and methodological skills for the development of the group’s research lines. During all these years, the group has had different projects financed jointly with national collaborators (Rovira i Virgili University [URV] of Tarragona; University of Castilla-La Mancha; Puerta del Mar University Hospital of Cádiz; University of Las Palmas de Gran Canary Islands) and international (Nalecz Institute of Biocybernetics and Biomedical Engineering in Warsaw, Poland; University of Caen, France).
The consolidated lines of research of the PO&B team focus on the study of the tumor microenvironment through digital image analysis and mathematical modeling. The immune response is one of the components of the tumor microenvironment that has been shown to play an important role in the evolution of cancer patients. Changes in the type and amount of immune cells in the tumor microenvironment have been related to differences in disease functionality. Our team has studied these changes through the development of new computer-assisted image analysis algorithms capable of providing more accurate and reproducible automated quantification of immune biomarkers with immunohistochemical and fluorescence staining.
The PO&B group has been recognized as a URV group since 2016, as an emerging group since 2009 and consolidated since 2014 by the Agency for the Management of University and Research Grants (AGAUR). Team members also coordinate the IISPV’s cross-platform and support platform for histological, pathological, and digitization studies.
The group is working with the strategic goal of improving the administration of current cancer treatments and detecting new therapeutic targets in breast cancer and lymphomas to reduce the risk of relapse and improve patient survival. The group’s lines of research are as follows:
1) Study of biomarker patterns of the tumor microenvironment. This line of research aims to identify patterns of immune response of the tumor microenvironment and etiological, pathophysiological, and prognostic factors linked to models of neoplasia progression (breast cancer and lymphoproliferative syndromes). These objectives can help to understand the biological mechanisms involved in the resistance to chemotherapy and the obtaining of new therapeutic targets with the capacity to intervene, as well as the constitution of new key factors in the diagnosis, prognosis, and treatment of these patients.
2) Morphometry and applied computing. This line of research aims to develop and improve new computer aids for computer-assisted image analysis to allow a more accurate and reproducible automated quantification of biomarkers of tumor cells and host of the tumor microenvironment with immunohistochemical staining. and fluorescence.
3) Translational research in hematological diseases: evaluation of diagnostic protocols and treatments. This line of research aims to expand the existing prior knowledge of blood diseases, of new procedures suitable for their diagnosis, and, very especially, of new treatments that allow the cure or at least prolong the life of the blood. people suffering from a hematological disease whether neoplastic or not.
Autors: Lukasz Roszkowiak L, KorzynskaA, Pijanowska D, Bosch R, Lejeune M, Lopez C.
Revista: EURASIP Journal on Image and Video Processing
Any i pàgina: EURASIP Journal on Image and Video Processing volume 2020, Article number: 26 (2020)
Autors: Sanegre S, Lucantoni F, Burgos-Panadero R, de La Cruz-Merino L, Noguera R, Álvaro Naranjo T.
Revista: Cancers (Basel)
Any i pàgina: 2020 Jun 24;12(6). pii: E1677. doi: 10.3390/cancers12061677
Autors: Ortega S, Halicek M, Fabelo H, Guerra R, Lopez C, Lejaune M, Godtliebsen F, Callico GM, Fei B.
Revista: Proc SPIE Int Soc Opt Eng
Any i pàgina: 2020 Feb;11320. pii: 113200V. doi: 10.1117/12.2548609.
Autors: Noguera R, Burgos-Panadero R, Lucantoni F, de la Cruz-Merino L, Álvaro Naranjo T.
Revista: Rev Esp Patol
Any i pàgina: 2020 Apr – Jun;53(2):88-99. doi: 10.1016/j.patol.2019.08.001. Epub 2019 Nov 22
Autors: Halicek M, Ortega S, Fabelo H, Lopez C, Lejaune M, Callico GM, Fei B.
Revista: Proc SPIE Int Soc Opt Eng
Any i pàgina: 2020 Feb;11320. pii: 113200U. doi: 10.1117/12.2549994.
Autors: Bussaglia E, Pratcorona M, Carricondo M, Sansegundo L, Rubio MA, Monter A, Brell A, Badell I, Esteve J, Arnan M, Talarn C, Tormo M, García A, Vall-Llovera F, Ortin X, Pedro C, Bargay J, Brunet S, Sierra J, Nomdedéu J.
Revista: Ann Hematol
Any i pàgina: 2020 Apr;99(4):765-772. doi: 10.1007/s00277-020-03910-0. Epub 2020 Feb 15.
López C, Gibert-Ramos A, Bosch R, Korzynska A, García-Rojo M, Bueno G, García-Fontgivell JF, González SM, Fontoura L, Navarro AG, Colón ES, Ribes JC, Roszkowiak L, Roso A, Berenguer M, Llobera M, Baucells J, Lejeune M.
2020 Dec 10 [Epub ahead of print]. Am J Pathol
DOI: 10.1016/j.ajpath.2020.11.008
López C, Bosch R, Orero G, Korzynska A, García-Rojo M, Bueno G, Fernández-Carrobles MDM, Gibert-Ramos A, Roszkowiak L, Callau C, Fontoura L, Salvadó MT, Álvaro T, Jaén J, Roso-Llorach A, Llobera M, Gil J, Onyos M, Plancoulaine B, Baucells J, Lejeune M.
Am J Pathol. 2020 Mar;190(3):660-673.
DOI: 10.1016/j.ajpath.2019.11.002
Noguera R, Álvaro Naranjo.
Cancers (Basel). 2020 Oct 9;12(10):2905.
DOI: 10.3390/cancers12102905
Blondon M, Jimenez D, Robert-Ebadi H, Del Toro J, Lopez-Jimenez L, Falga C, Skride A, Font L, Vazquez FJ, Bounameaux H, Monreal M; RIETE investigators.
2020 Dec 19 [Epub ahead of print]. J Thromb Haemost
DOI: 10.1111/jth.15146
López C, Bosch-Príncep R, Orero G, Fontoura Balagueró L, Korzynska A, García-Rojo M, Bueno G, Fernández-Carrobles MDM, Roszkowiak L, Callau Casanova C, Salvadó-Usach MT, Jaén Martínez J, Gibert-Ramos A, Roso-Llorach A, Gras Navarro A, Berenguer-Poblet M, Llobera M, Gil Garcia J, Tomás B, Gestí V, Laine E, Plancoulaine B, Baucells J, Lejeune M.
PeerJ. 2020 Sep 2;8:e9779.
DOI: 10.7717/peerj.9779
Valentí V, Ramos J, Pérez C, Capdevila L, Ruiz I, Tikhomirova L, Sánchez M, Juez I, Llobera M, Sopena E, Rubió J, Salazar R.
Clin Transl Oncol. 2020 Jun;22(6):935-942.
DOI: 10.1007/s12094-019-02216-6
Forcadell Drago E, Dalmau Llorca MR, Aguilar Martín C, Ferreira-González I, Hernández Rojas Z, Gonçalves AQ, López-Pablo C.
Int J Environ Res Public Health. 2020 Nov 19;17(22):8590.
DOI: 10.3390/ijerph17228590
S Reverté-Villarroya, A Dávalos, S Font-Mayolas, M Berenguer-Poblet, E Sauras-Colón, C López-Pablo, E Sanjuan-Menéndez , L Muñoz-Narbona, R Suñer-Soler
Int J Environ Res Public Health. 2020 Aug 19;17(17):6014.
DOI: 10.3390/ijerph17176014
Tresserra F, Temprana J, Vasquez C, Lloveras B, Català I, Tarroch X, Combalia N, Alameda F, Bosch R, Gallardo J, Mancebo E, Fabra G, Dinares MC, Santacana M, Gonzalez C, Pérez-Ochoa F.
2020 Oct 19 [Epub ahead of print]. Diagn Cytopathol
DOI: 10.1002/dc.24639
Gentille-Lorente D, Salvadó-Usach T.
Arch Cardiol Mex. 2020;90(3):266-273.
DOI: 10.24875/ACM.20000240
Gentille-Lorente D, Salvadó-Usach T.
Arch Cardiol Mex. 2020 Nov 24;91(1):135-138.
DOI: 10.24875/ACM.20000239
Autors: López C, Bosch R, Orero G, Korzynska A, García-Rojo M, Bueno G, Fernández-Carrobles MM, Gibert-Ramos A, Roszkowiak L, Callau C, Fontoura L, Salvadó MT, Álvaro T, Jaén J, Roso-Llorach A, Llobera M, Gil J, Onyos M, Plancoulaine B, Baucells J, Lejeune M.
Revista: Am J Pathol
Any i pàgina: 2019 Dec 19. pii: S0002-9440(19)30860-0. doi: 10.1016/j.ajpath.2019.11.002.
Autors: Gibert-Ramos A, López C, Bosch R, Fontoura L, Bueno G, García-Rojo M, Berenguer M, Lejeune M.
Revista: Histochem Cell Biol
Any i pàgina: 2019 Jul 13. doi: 10.1007/s00418-019-01802-7
Autors: Burgos-Panadero R, Lucantoni F, Gamero-Sandemetrio E, Cruz-Merino L, Naranjo TÁ, Noguera R.
Revista: Cancer Lett
Any i pàgina: 2019 Jul 17. pii: S0304-3835(19)30406-9. doi: 10.1016/j.canlet.2019.07.010
Autors: Noguera R, Burgos-Panadero R, Gamero-Sandemetrio E, de la Cruz-Merino L, Álvaro Naranjo T.
Revista: Rev Esp Patol
Any i pàgina: 2019 Apr – Jun;52(2):92-102. doi: 10.1016/j.patol.2018.11.003. Epub 2019 Feb 10
Autors: Noguera R, Burgos-Panadero R, Gamero-Sandemetrio E, de la Cruz-Merino L, Álvaro Naranjo T.
Revista: Rev Esp Patol
Any i pàgina: 2019 Oct – Dec;52(4):222-233. doi: 10.1016/j.patol.2019.04.005. Epub 2019 Jun 11
Autors: Naranjo T.
Revista: Rev Esp Patol
Any i pàgina: 2019 Apr – Jun;52(2):69-71. doi: 10.1016/j.patol.2018.10.004.
Autors: Ribera J, Granada I, Morgades M, Vives S, Genescà E, González C, Nomdedeu J, Escoda L, Montesinos P, Mercadal S, Coll R, González-Campos J, Abella E, Barba P, Bermúdez A, Gil C, Tormo M, Pedreño M, Martínez-Carballeira D, Hernández-Rivas JM, Orfao A, Martínez-López J, Esteve J, Bravo P, Garcia-Guiñon A, Debén G, Moraleda JM, Quiezán JA, Ortín X, Moreno MJ, Feliu E, Solé F, Ribera JM; PETHEMA Group, Spanish Society of Haematology.
Revista: Br J Haematol
Any i pàgina: 2019 Jul;186(2):263-268. doi: 10.1111/bjh.15887.
Autors: Fuentes HE, Tafur AJ, Caprini JA, Alatri A, Trujillo-Santos J, Farge-Bancel D, Rosa V, Font L, Vilaseca A, Monreal M; RIETE Investigators.
Revista: Int Angiol
Any i pàgina: 2019 Jun;38(3):173-184. doi: 10.23736/S0392-9590.19.04110-5
Autors: Algaba-Chueca F, Maymó-Masip E, Ejarque M, Ballesteros M, Llauradó G, López C, Guarque A, Serena C, Martínez-Guasch L, Gutiérrez C, Bosch R, Vendrell J, Megía A, Fernández-Veledo S.
Revista: Stem Cells Transl Med
Any i pàgina: 2019 Dec 27. doi: 10.1002/sctm.19-0242
Autors: Aguilar Martín C, Gonçalves AQ, López-Pablo C, Fernández-Sáez J, Forcadell Drago E, Hernández Rojas Z, Pepió Vilaubí JM, Rodríguez Cumplido D, Piñol JL, Bladé-Creixenti J, Dalmau Llorca MR
Revista: Int J Environ Res Public Health
Any i pàgina: 2019 Nov 5;16(21). pii: E4299. doi: 10.3390/ijerph16214299
Title: R-GDP with Lenalidomide (R2-GDP) in patients with relapsed or refractory diffuse large B cell lymphoma (r/r DLBCL) not suitable for high dose therapy and stem-cell transplantation.
Funding entity: Celgene
Duration: 2014-2019
Principal Investigator: Luis de la Cruz Merino (GOTEL)
Collaborationg investigators: T. Álvaro MD, PhD – M. Lejeune BSc, PhD
Title: Incidencia de carcinoma in situ y cáncer de cérvix específica por genotipo del virus del papiloma humano (VPH) en las provincias de Girona y de Tarragona.
Funding entity: ICO
Duration: 2014-2018
Principal Investigator: Silvia de Sanjosé Llongueras
Collaborationg investigators: R. Bosch MD.
Title: Análisis automatizado de biomarcadores del microambiente tumoral en cáncer de mama triple negativo sin respuesta patológica completa a la neoadyuvancia. Factores predictivos de recaída (PI13/02501).
Funding entity: Instituto de Salud Carlos III
Duration: 2014-06/2017
Principal Investigator: M. Lejeune BSc, PhD.
Title: Desarrollo de metodologías automatizadas para establecer patrones de respuesta inmune mediante la cuantificación de marcadores inmunohistoquímicos en cáncer de mama (PI11/00488).
Funding entity: Instituto de Salud Carlos III
Duration: 2012-2014
Principal Investigator: C. López BSc, PhD.
IC30-20
ORGANIZATION
Department of Human Nutrition of
the Rovira i Virgili University
FINAL DATE
09/11/2020
Servei d’Anatomia Patològica
Area de Biologia Molecular i Recerca
Hospital de Tortosa Verge de la Cinta
C/Esplanetes 14
43500 Tortosa
see google maps
Responsible: Matilde Rodríguez Chacón
Responsible: Matilde Rodríguez Chacón
Responsible: Joan Lluís Borràs Balada, Josep Gumà Padró
Responsible: Meritxell Arenas Prat