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Autoimmunity, Infection and Thrombosis (GRAIÏT)

INFECTION, IMMUNITY AND ENVIRONMENT
SEPSIS MALALTIES INFECCIOSES TOXICOLOGIA MICROBIOLOGIA
TARGETS

The GRAIÏT group is made up of a multidisciplinary team of doctors, with significant clinical experience, teaching and research activity (8 doctors and 5 pre-doctoral students). It works together to expand the knowledge of autoimmune and infectious diseases. The main field of research is focused on the study of the physio pathogenic bases of these diseases with the aim to identify new biomarkers and possible therapeutic targets.

Furthermore, these diseases share elements related to a state of chronic inflammation leading to the development of metabolic alterations, cardiovascular risk and thrombotic events which mark the prognosis and morbidity and mortality of these patients.

Since 2020, GRAÏIT is also focused on the research of prognostic biomarkers and therapeutic targets in COVID-19 and persistent symptoms (post-COVID).

RESPONSIBLE

  • Dr. Antoni Castro Salomó

  • Dra. Sandra Parra Pérez

  • Group members
  • Research lines
  • Competitive projects
  • NON-COMPETITIVE PROJECTS FINANCED IN RECENT YEARS
  • Publications
  • DOCTORAL THESES
  • RELEVANCE TO ADVISORY COMMITTEES AND/OR MEMBERS OR EXPERT GROUPS OF SCIENTIFIC SOCIETIES AND/OR OFFICIAL BODIES.
  • Contact
  • Study of cardiovascular risk and subclinical arteriosclerosis in patients with Systemic Lupus Erythematosus (SLE)
  • Investigation of subclinical atherosclerosis markers in patients with SLE (carotid intima-media thickness, endothelial function and arterial stiffness)
  • Lipidomic and proteomic study of lipoproteins in patients with SLE
  • Investigation of activity biomarkers in patients with SLE (Gelsolin)
  • Study of prognostic markers of catheter-associated infections and healthcare system infections.
  • Study of new prognostic biomarkers in patients admitted for community-acquired pneumonia (CAP) and for COVID-19. ACRONYM NAC-HDL COVID-19.
  • Gelsolin: a biomarker and potential treatment for the post-Covid patient.
  • Prognostic markers and cardiovascular risk in patients with Psoriasis

  • FUNDACIÓ MARATÓ TV3 IDENTIFICATION OF BIOMARKERS NASED ON ENERGY METABOLISM AND OXIDATIVE STRESS IN PATIENTS WITH URINARY CATHETER-ASSOCIATED INFECTIONS AND DEVELOPMENT OF BIOSENSORS FOR THEIR DETEMRINATION IN PRIMARY AND HOSPITAL CARE . J CAMPS. (FUNDACIÓ PRIVADA INVESTIGACIONS SANITARIES PERE VIRGILI). 6/3/18-18/6/21. 197.000

  • Beca de Investigación Básica 2016 de la Academia de Ciencias Médicas y de la Salud de Cataluña y Baleares, por el proyecto Efectividad de un Smartwatch en la activación del circuito de Reanimación Cardiopulmonar en pacientes con paro cardiorrespiratorio en la calle. Academia de las Ciencias Médicas de Cataluña y Baleares. Josep Basorar et al. (Instituto Catalán de la Salud) Desde 2016-actualidad. 20.000 euros.

  • SAL-OSTEOP-2010-01 (ESTUDIO FRATER) “Utilidad de la herramienta FRAX para predecir el riesgo de fractura en pacientesatendidos en consultas de reumatología en España”.

  • ROC-TOC-2011-01 (ACT-AXIS) “Estudio observacional, prospectivo, para evaluar y correlacionar el impacto del tratamiento con RoActemra® (Tocilizumab) sobre la fatiga y diferentes factores que influyen en ella en pacientes con artritis reumatoide en la práctica clínica habitual.Estudio ACT-A”

  • ABB-LOP-2010-01“Percepción del tratamiento con Kaletra (comprimidos) dosificado 1 vez al día en PacientesInfectados por VIH. Estudio TransversAL (QD-KAPITAL)”. (FINALITZAT 2012)

  • ORDI-01” Ensayo clínico aleatorizado y controlado para evaluar la eficacia de la azatioprina vs. micofenolatosódico para el tratamiento de la fase de inducción y mantenimiento de la remisión de los brotes extra renales del lupus eritematoso”.

  • NOV-ANT-2011-01“Prevalencia y manejo clínico de pacienteshospitalizadosinfectados por grampositivos con insuficiencia renal en España. Estudio Daptokidney: Fases Prevenir y Evaluar.” (ESTUDIO DAPTOKIDNEY)

  • ESTUDIO SEQUENCE “Oportunidades de secuenciación intravenosa a oral y de alta precoz en infecciones por grampositivos que precisan de tratamiento con un glucopéptido o lipopéptido”.

  • BAY-RIV-2012-01 ” XALIA Xarelto© para la Anticoagulación a Largo plazo e Inicial en el tromboembolismo venoso (TEV) “.

  • SHI-TSE-2011-01 “Estudio epidemiológico sobre el estado actual de los pacientes con enfermedad de Gaucher tipo I en España, evaluados mediante la TherapeuticGoals MAP (Monitor, ActionandProgress) Tool© “. Estudio MAPPING EG.

  • SAP-02 “rivaroxaban versus acenocumarol en la profilaxis secundaria del síndrome  tifosfolípido: un estudio multicéntrico, prospectivo y randomizado. análisis de factores de estratificaciónpronóstica de evolución clínica.”

  • BMS-ACO-2014-01 ESTUDIO PERFILAR:“Estudio multicéntrico observacional para determinar el perfil y manejo del tratamiento antitrombótico de los pacientes con fibrilación auricular no valvular que acuden a los servicios de medicina interna de los hospitales españoles” Código CV185372

  • CE01-301: Study drug Solthromycin . CEM-101 A Randomized, Double – Blind, Multi -Center Study to Evaluate the Efficacy and Safety of Intravenous to Oral Solithromycin (CEM -101) Compared to Intravenous to Oral Moxifloxacin in the Treatment of Adult Patients with Community -Acquired Bacterial Pneumonia

  • LCD-CDAD-10-07/11-06 A Randomized, Double-Blinded, Active-Controlled Study of CB-183, 315 in Patients with Clostridium Difficile Associated Diarrea. Cubist Pharmaceuticals.

  • Títol del projecte: Arteriosclerosis subclínica en pacientes con enfermedades sistémicas. Colección de muestras biológicas y estudio vascular en pacientes con LES en el momento inicial, a los 3 años de seguimiento y en brote clínico. IP: Antoni Castro. Inici 2006-vigent

  • TÍTOL DEL PROJECTE: (NAC-HDL) Relación entre los factores pronósticos de los pacientes ingresados por neumonía adquirida en la comunidad (NAC) y el estudio de funcionalidad y composición de las partículas de colesterol HDL IP: Sandra Parra, Antoni Castro 2012-vigent

  • ESTUDI FASE III, ALEOATORITZAT, AMB DOBLE ENMASCARAMENT I COMPRADOR ACTIU DE LA EFICACIA I LA SEGURETAT ENTRE RIDINILAZOL (200mg, 2 C/dia) DURANTE 10 DIAS I VANCOMICINA (125 mg, 4 cops/dia) DURANT 10 DIES PER AL TRACTAMENT DE LA INFECCIÓ PER CLOSTRIDIUM DIFFICILE (ICD). Antoni Castro Salomó. 15/10/2019-15/10/2022) 10.524 Euros.

  • A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept study to evaluate the Efficacy and Safety of Recombinant Human Plasma Gelsolin (rhu-pGSN) added to Standard of Care for Treatment of Subjects with Severe COVID-19 Pneumonia. BIoaegis. IP: Antoni Castro, Co_IP: Sandra parra 1/8/2020-1/8/2021. 180.000 euros.

    Year

    Combining Semi-Targeted Metabolomics and Machine Learning to Identify Metabolic Alterations in the Serum and Urine of Hospitalized Patients with COVID-19.

    Baiges-Gaya, G.; Iftimie, S.; Castañé, H.; Rodríguez-Tomàs, E.; Jiménez-Franco, A.; López-Azcona, A.F.; Castro, A.; Camps, J.; Joven, J.. Biomolecules2023, 13, 163.

    DOI: 10.3390/biom13010163

    Characteristics of hospitalized patients with SARS-CoV-2 infection during successive waves of the COVID-19 pandemic in a reference hospital in Spain.

    Iftimie, S., López-Azcona, A.F., Lozano-Olmo, M.J. et al.. Sci Rep 12, 17384 (2022).

    DOI: 10.1038/s41598-022-22145-9

    Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study.

    Iftimie, S.; Hernández-Aguilera, A.; López-Azcona, A.F.; Castañé, H.; Rodríguez-Tomàs, E.; Baiges-Gaya, G.; Camps, J.; Castro, A.; Joven, J.. Diagnostics2022, 12, 2418.

    DOI: 10.3390/diagnostics12102418

    Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19.

    Gabaldó, X.; Juanpere, M.; Castañé, H.; Rodríguez-Tomàs, E.; López-Azcona, A.F.; Baiges-Gaya, G.; Castro, L.; Valverde-Díaz, E.; Muñoz-Blázquez, A.; Giménez-Cuenca, L.; Felipo-Balada, L.; Ballester, F.; Pujol, I.; Simó, J.M.; Castro, A.; Iftimie, S.; Camps, J.; Joven, J. Biomolecules2022, 12, 879.

    DOI: 10.3390/biom12070879

    Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients.

    Castañé, H.; Iftimie, S.; Baiges-Gaya, G.; Rodríguez-Tomàs, E.; Jimenez-Franco, A.; López-Azcona, A.F.; Garrido, P.; Castro, A.; Camps, J.; Joven, J. Metabolism 2022, 131, 155197.

    DOI: 10.1016/j.metabol.2022.155197

    Triglyceride-Rich Lipoproteins and Glycoprotein A and B Assessed by 1H-NMR in Metabolic-Associated Fatty Liver Disease.

    Moreno-Vedia, J.; Rosales, R,; Ozcariz, E.; Llop, D.; Lahuerta, M.; Benavent, M.; Rodríguez-Calvo, R.; Plana, N.; Pedragosa A.; Masana, Ll.; Castro, A.; Ibarretxe, D.; Girona, J. Frontiers in Endocrinology, 2022, 12

    DOI: 10.3389/fendo.2021.775677

    Characterization of the LPS and 3OHFA Contents in the Lipoprotein Fractions and Lipoprotein Particles of Healthy Men.

    Rehues, P.; Rodríguez, M.; Álvarez, J.; Jiménez, M.; Melià, A.; Sempere, M.; Balsells, C.; Castillejo, G.; Guardiola, M.; Castro, A.; Ribalta, J.  Biomolecules2022, 12, 47.

    DOI: 10.3390/biom12010047

    Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers.

    Malo AI.; Peraire, J.; Ruiz-Mateos, E.; Masip, J.; Amigó, N.; Alcamí, J.; Moreno, S.; Girona, J.; García-Pardo, G.; Reig, R.; Vidal, F.; Castro, A.; Masana, L.; Rull, A. Frontiers in Endocrinology 2021, 28, 730691.

    DOI: 10.3389/fimmu.2021.730691

    Clinical performance of the Elecsys anti-SARS-CoV-2 combined in an algorithm with two specific anti-IgG immunoassays for the evaluation of the serological response of patients with COVID-19 in apopulation with a high prevalence of infection.

    Gabaldó-Barrios, X.; Iftimie, S.; Hernández-Aguilera, A.; Pujol, I.; Ballester, F.; Fernández, L.; Cladellas, S.; Castro, A.; Joven, J.; Camps, J.; Simó, JM. Annals of Clinical Biochemistry. 2021 58(6):614-621.

    DOI: 10.1177/00045632211038038

    Study of the Plasma and Buffy Coat in Patients with SARS-CoV-2 Infection-A Preliminary Report.

    Peña, KB.; Riu, F.; Gumà, J.; Guilarte, C.; Pique, B.; Hernandez, A.; Àvila, A.; Parra, S.; Castro, A.; Rovira, C.; Cueto, P.; Vallverdu, I.; Parada, D. Pathogens. 2021 25; 805. PMID: 34201967

    DOI: 10.3390/pathogens10070805

    Clinical Performance of Paraoxonase-1-Related Variables and Novel Markers of Inflammation in Coronavirus Disease-19. AMachine Learning Approach.

    Rodríguez-Tomàs E, Iftimie S, Castañé H, Baiges-Gaya G, Hernández-Aguilera A, González-Viñas M, Castro A, Camps J, Joven J. Antioxidants (Basel). 2021 21, 6, 991.

    DOI: 10.3390/antiox10060991

    First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain.

    Iftimie S, López-Azcona AF, Vallverdú I, Hernández-Flix S, de Febrer G, Parra S, Hernández-Aguilera A, Riu F, Joven J, Andreychuk N, Baiges-Gaya G, Ballester F, Benavent M, Burdeos J, Català A, Castañé È, Castañé H, Colom J, Feliu M, Gabaldó X, Garrido D, Garrido P, Gil J, Guelbenzu P, Lozano C, Marimon F, Pardo P, Pujol I, Rabassa A, Revuelta L, Ríos M, Rius-Gordillo N, Rodríguez-Tomàs E, Rojewski W, Roquer-Fanlo E, Sabaté N, Teixidó A, Vasco C, Camps J, Castro A. PLoS One. 2021 Mar 31, 3;

    DOI: 10.1371/journal.pone.0248029

    Low-density lipoprotein from active SLE patients is more atherogenic to endothelial cells than low-density lipoprotein from the same patients during remission.

    Rodríguez-Calvo R, Guardiola M, Oliva I, Arrando H, Arranz I, Ferré A, Pellicer P, Parra S, Ribalta J, Castro A. Rheumatology (Oxford). 2021 1, 2, 866-871.

    DOI: 10.1093/rheumatology/keaa380

    Betanin and Peripheral Artery Vasospasm.

    Camps J, Iftimie S, Castro A, Joven J. . Journal of Investigative Surgery 2021 34(2):214-215.

    DOI: 10.1080/08941939.2019.1599085

    Influence of Surgical Procedures on Serum Paraoxonase-1-Related Variables and Markers of Inflammation in Hospitalized Patients.

    Iftimie S, Escribano A, Díez-Sans A, Albiciuc I, Hernández-Aguilera A, Fort-Gallifa I, López-Azcona AF, Camps J, Joven J, Castro A. Journal of Investigative Surgery 2021, 34, 2, 216-224.

    DOI: 10.1080/08941939.2019.1597223

    Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers.

    Malo AI, Peraire J, Ruiz-Mateos E, Masip J, Amigó N, Alcamí J, Moreno S, Girona J, García-Pardo G, Reig R, Vidal F, Castro A, Masana L, Rull A. Frontiers in Immunology. 2021 28, 12, 730691.

    DOI: 10.3389/fimmu.2021.730691

    Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis

    Taverner D, Llop D, Rosales R, Ferré R, Masana L, Vallvé JC, Paredes S. Scientific Reports 2021 2, 1, 15670.

    DOI: 10.1038/s41598-021-95234-w

    Demographic, clinical, and functional determinants of antithrombotic treatment in patients with nonvalvular atrial fibrillation.

    Mostaza JM, Suarez C, Cepeda JM, Manzano L, Sánchez D; PERFILAR study investigators. BMC Cardiovasc Disorders. 2021 9, 1, 384.

    DOI: 10.1186/s12872-021-02019-0

    Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain.

    Iftimie S, López-Azcona AF, Vicente-Miralles M, Descarrega-Reina R, Hernández-Aguilera A, Riu F, Simó JM, Garrido P, Joven J, Camps J, Castro A. PLoS One. 2020 3, 9.

    DOI: 10.1371/journal.pone.0234452

    Gelsolin: a new biomarker of disease activity in SLE patients associated with HDL-c.

    Parra S, Heras M, Herrero P, Amigó N, Garcés E, Girona J, Correig X, Canela N, Castro A. Rheumatology (Oxford). 2020 1, 3, 650-661.

    DOI: 10.1093/rheumatology/kez293

    The impact of flushing with pre-filled saline syringes on the incidence of peripheral venous catheter failure: Aquasi-experimental study.

    Saliba P, Cuervo G, Hornero A, De Carli G, Marani A, Puro V, Felisa López A, Iftimie S, Castro A, Diaz-Brito Fernandez V, Alvarez Moya MC, Jimenez De La Rosa C, Martínez-Sánchez J, Jimenez E, Carratalà J, Pujol M.J.  The Journal of Vascular Access. 020 21, 4, 490-496.

    DOI: 10.1177/1129729819888423

    Hemodynamic effects of blood clots trapped by an inferior vena cava filter.

    López JM, Fortuny G, Puigjaner D, Herrero J, Marimon F. International Journal of Numerical Methods in Biomedical Engineering. 2020 36, 7

    DOI: 10.1002/cnm.3343

    Low-density lipoprotein net charge is arisk factor for atherosclerosis in lupus patients independent of lipid concentrations.

    Rodríguez M, Guardiola M, Oliva I, Carles Vallvé J, Ferré R, Masana L, Parra S, Ribalta J, Castro A. International Journal of Rheumatic Diseases 2019; 22, 3, 480-487.

    DOI: 10.1111/1756-185X.13445

    Assessment of arterial stiffness variables in patients with rheumatoid arthritis: Amediation analysis.

    Taverner D, Paredes S, Ferré R, Masana L, Castro A, Vallvé JC. Scientific reports. 2019 14, 1, 4543.

    DOI: 10.1038/s41598-019-41069-5

    Effectiveness of anetwork of automatically activated trained volunteers on the reduction of cardiopulmonary resuscitation manoueuvers initiation time: study protocol.

    Del Pozo A, Villalobos F, Rey-Reñones C, Granado E, Sabaté D, Poblet C, Calvet A, Basora J, Castro A, Flores G. BMC Public Health. 2019 14, 1, 572.

    DOI: 10.1186/s12889-019-6896-9

    Lay People Training in CPR and in the Use of an Automated External Defibrillator, and Its Social Impact: ACommunity Health Study.

    Villalobos F, Del Pozo A, Rey-Reñones C, Granado-Font E, Sabaté-Lissner D, Poblet-Calaf C, Basora J, Castro A, Flores-Mateo G. International Journal of Environmental Research and Public Health. 2019; 11, 16, 2870.

    DOI: 10.3390/ijerph16162870

    Patients With Systemic Lupus Erythematosus Show an Increased Arterial Stiffness That is Predicted by IgM Anti-β2-Glycoprotein I and Small Dense High-Density Lipoprotein Particles.

    Parra S, Lopez-Dupla M, Ibarretxe D, de Las Heras M, Amigó N, Català A, Benavent M, Garcés E, Navarro A, Castro A. Arthritis Care & Research (Hoboken). 2019; 71, 1, 116-125.

    DOI: 10.1002/acr.23594

    MicroRNA differential expression shared between rheumatoid arthritisand acute myocardial infarction: an exploratory study.

    Paredes S, Taverner D, Ferré R, Alegret JM, Masana L, Vallvé JC. Clinical and Experimental Rheumatology. 2019 37, 5, 886-887. PMID: 31172919

    Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis.

    Taverner D, Paredes S, Ferré R, Masana L, Castro A, Vallvé JC. Scientific Reports. 2019 14, 1, 4543.

    DOI: 10.1038/s41598-019-41069-5

    Serum Paraoxonase-1 Concentration as aPotential Predictor of Urinary Bladder Cancer Recurrence. A Five-Year Follow-Up Study.

    Iftimie S, García-Heredia A, Pujol-Bosch F, Pont-Salvadó A, López-Azcona AF, Hernández-Aguilera A, Cabré N, Luciano-Mateo F, Fort-Gallifa I, Castro A, Camps J, Joven J. Archives of Medical Research. 2018; 49, 2, 119-122.

    DOI: 10.1016/j.arcmed.2018.04.011

    Variables associated with subclinical atherosclerosis in a cohort of rheumatoid arthritis patients: Sex-specific associations and differential effects of disease activity and age.

    Taverner D, Vallvé JC, Ferré R, Paredes S, Masana L, Castro A. PLoS One. 2018; 1, 3.

    DOI: 10.1371/journal.pone.0193690

    Preoperative oral antibiotic prophylaxis reduces Pseudomonas aeruginosa surgical site infections after elective colorectal surgery: amulticenter prospective cohort study.

    Gomila A, Carratalà J, Badia JM, Camprubí D, Piriz M, Shaw E, Diaz-Brito V, Espejo E, Nicolás C, Brugués M, Perez R, Lérida A, Castro A, Biondo S, Fraccalvieri D, Limón E, Gudiol F, Pujol M; VINCat Colon Surgery Group. BMC Infectious Diseases. 2018; 5, 1, 507.

    DOI: 10.1186/s12879-018-3413-1

    Multistate modelling to estimate excess length of stay and risk of death associated with organ/space infection after elective colorectal surgery.

    Shaw E, Gomila A, Piriz M, Perez R, Cuquet J, Vazquez A, Badia JM, Lérida A, Fraccalvieri D, Marron A, Freixas N, Castro A, Cruz A, Limón E, Gudiol F, Biondo S, Carratalà J, Pujol M; VINCat colon surgery group. Journal of Hospital Infection. 2018; 100, 4, 400-405.

    DOI: 10.1016/j.jhin.2018.08.010

    Characterization of (1)H NMR Plasma Glycoproteins as a New Strategy To Identify Inflammatory Patterns in Rheumatoid Arthritis.

    Fuertes-Martín R, Taverner D, Vallvé JC, Paredes S, Masana L, Correig Blanchar X, Amigó Grau N. Journal of Proteome Research. 2018; 2, 11, 3730-3739.

    DOI: 10.1021/acs.jproteome.8b00411

    A comparative CFD study of four inferior vena cava filters. International Journal of Numerical Methods in Biomedical Engineering. 2018 34, 7, e2990.

    López JM, Fortuny G, Puigjaner D, Herrero J, Marimon F.

    DOI: 10.1002/cnm.2990

    Current outcomes and predictors of treatment failure in patients with surgical site infection after elective colorectal surgery. Amulticentre prospective cohort study.

    Gomila A, Badia JM, Carratalà J, Serra-Aracil X, Shaw E, Diaz-Brito V, Castro A, Espejo E, Nicolás C, Piriz M, Brugués M, Obradors J, Lérida A, Cuquet J, Limón E, Gudiol F, Pujol M; VINCat Colon Surgery Group. Journal of Infection 2017; 74, 6, 555-563.

    DOI: 10.1016/j.jinf.2017.03.002

    Paraoxonases and infectious diseases.

    Camps J, Iftimie S, García-Heredia A, Castro A, Joven J. Clinical Biochemistry. 2017; 50, 13-14, 804-811.

    DOI: 10.1016/j.clinbiochem.2017.04.016

    Clinical characteristics during diagnosis of aprospective cohort of patients with systemic lupus erythematosus treated in Spanish Departments of Internal Medicine: The RELES study.

    Canora J, García M, Mitjavila F, Espinosa G, Suárez S, González-León R, Sopeña B, Boldova R, Castro A, Ruiz-Irastorza G; en representación de los investigadores del Registro RELES-Grupo de Enfermedades Autoinmunes Sistémicas (GEAS). Revista Clínica Española (BARC) 2017 217, 1, 7-14.

    DOI: 10.1016/j.rce.2016.09.006

    Apreliminary study of paraoxonase-1 in infected patients with an indwelling central venous catheter.

    Iftimie S, García-Heredia A, Pujol I, Ballester F, Fort-Gallifa I, Simó JM, Joven J, Castro A, Camps J. Clinical Biochemistry. 2016 Apr;49(6):449-457.

    DOI: 10.1016/j.clinbiochem.2015.11.006

    Patterns of drug therapy in newly diagnosed Spanish patients with systemic lupus erythematosus.

    Ruiz-Irastorza G, García M, Espinosa G, Cabezas-Rodríguez I, Mitjavila F, González-León R, Sopeña B, Perales I, Pinilla B, Rodríguez-Carballeira M, López-Dupla JM, Callejas JL, Castro A, Tolosa C, Sánchez-García ME, Pérez-Conesa M, Navarrete-Navarrete N, Rodríguez AP, Herranz MT, Pallarés L; RELES, Autoimmune Diseases Study Group GEAS. Clinical and Experimental Rheumatology. 2016 34, 3, 466-72. PMID: 26940538

    Off-label use of rituximab for systemic lupus erythematosus in Europe.

    Rydén-Aulin M, Boumpas D, Bultink I, Callejas Rubio JL, Caminal-Montero L, Castro A, Colodro Ruiz A, Doria A, Dörner T, Gonzalez-Echavarri C, Gremese E, Houssiau FA, Huizinga T, Inanç M, Isenberg D, Iuliano A, Jacobsen S, Jimenéz-Alonso J, Kovács L, Mariette X, Mosca M, Nived O, Oristrell J, Ramos-Casals M, Rascón J, Ruiz-Irastorza G, Sáez-Comet L, Salvador Cervelló G, Sebastiani GD, Squatrito D, Szücs G, Voskuyl A, van Vollenhoven R. Lupus Science & Medicine. 2016; 6, 1

    DOI: 10.1136/lupus-2016-000163

    First month prednisone dose predicts prednisone burden during the following 11 months: an observational study from the RELES cohort.

    Ruiz-Irastorza G, Garcia M, Espinosa G, Caminal L, Mitjavila F, González-León R, Sopeña B, Canora J, Villalba MV, Rodríguez-Carballeira M, López-Dupla JM, Callejas JL, Castro A, Tolosa C, Sánchez-García ME, Pérez-Conesa M, Navarrete-Navarrete N, Rodríguez AP, Herranz MT, Pallarés L. Lupus Science & Medicine. 2016 2,1

    DOI: 10.1136/lupus-2016-000153

    Preliminary study on serum paraoxonase-1 status and chemokine (C-C motif) ligand 2 in hospitalized elderly patients with catheter-associated asymptomatic bacteriuria.

    Iftimie S, García-Heredia A, Pujol I, Ballester F, Fort-Gallifa I, Simó JM, Joven J, Camps J, Castro A. European Journal Clinical Microbiology and Infection Diseases. 2016 35, 9, 1417-24.

    DOI: 10.1007/s10096-016-2679-8

    HDL-c levels predict the presence of pleural effusion and the clinical outcome of community-acquired pneumonia.

    Saballs, M.; Parra, S.; Sahun, P.; Pellejà, J.; Feliu, M.; Vasco, C.; Gumà, J.; Borràs JL.; Masana L.; Castro, A. 2016 6, 15, 1491.

    DOI: 10.1186/s40064-016-3145-x

    The pleiotropic role of HDL in autoimmune diseases

    Parra, S.; Castro A, Masana L. Clínica e Investigación en Arteriosclerosis. 2015, 27:97-106.

    DOI: 10.1016/j.arteri.2014.09.002

  • Els doctors Antoni Castro I Sandra Parra dirigeixen actualment la següent tesi doctoral

    Doctorant: Mireia Saballs Nadal

    Títol: Relació entre els factors pronòstic de la pneumònia adquirida a la comunitat, i la concentració, funcionalitat i composició de les partícules de colesterol HDL.

    Any de defensa i calificació: Actiu (possiblement 2023)

    Supervisors: Sandra Parra Pérez i Antoni Castro Salomó, Universitat Rovira i Virgili.

  • En anys anteriors, el Dr. Castro ha dirigit les següents tesis doctorals:

    Doctorant: Marta González

    Títol: Alterations in the metabolsim of tryglicerides in Systemic Lupus Erythematosus.

    Any de defensa i calificació: 2016, Cum Laude.

    Supervisors: Antoni Castro i Josep Rivalta, Universitat Rovira i Virgili.

  • Doctorant: Miguel Camafort Babkowski

    Títol: Artherial pressure ambulatory monitoring utility in the prognostic of patients with heart failure.

    Any de defensa i calificació: 2016, Distinction.

    Supervisor: Antoni Castro, Universitat Rovira i Virgili.

  • Doctorant: Simona Micaela Iftime

    Títol: Paraoxonase-1 in patients with catheter associated infections

    Any de defensa i calificació: 2015, Cum Laude.

    Supervisor: Antoni Castro, Universitat Rovira i Virgili.

  • Grupo de Enfermedades Autoinmunes Sistémicas (GEAS-SEMI). Sociedad Española de Medicina Interna (Antoni Castro Salomó, Sandra Parra Pérez)
  • Línea de investigación Esclerodermia-REMSCLE (Antoni Castro Salomó, Sandra Parra Pérez)
  • Registro Español de pacientes con Lupus Eritematoso Sitémico (RELES)
  • Registro Español de pacientes tratados con Belilumab (BeliLESGEAS)
  • Estudio EPINE. Estudio de prevalencia de la infección nosocomial en España

Team Members

  • Group responsible

    • Dr. Antoni Castro Salomó

  • Group co-responsible

    • Dra. Sandra Parra Pérez

  • Clinical members

    • Mireia Feliu Masgoret
    • Francesc Marimon Cortes
    • Pedro Pardo Reche
    • Delia Taverner Torrent
    • Michaela Iftimie
    • Antoni Azón Masoliver
    • Cristina Grau Salvat
    • Carles Garcia Cervera
    • Raül Pavón Amador
    • Francisco Rubio

  • Tecnical members

    • David Parada Domínguez
    • Raül Pavón Amador
    • Jorge Sánchez Cortés (R1)
    • Xavi Gavaldó Barrios

Altres grups de Infection, Immunity and Environment

See all