Tarragona hosted the 23rd Liver Sinusoid Meeting 2026 from May 22 to 26. This is one of the main international meetings in the field of liver blood vessel biology. The congress brought together around 200 researchers and clinicians from different countries and placed the city and its biomedical research ecosystem at the center of the international scientific scene.
Jordi Gracia-Sancho, a researcher at IRB CatSud and head of the Liver Research Unit, was part of the organising committee and one of the main promoters of the meeting. The event also included the participation of Sonia Fernández-Veledo, co-leader of the Diabetes and Associated Metabolic Diseases research group (DIAMET), highlighting the important role of local researchers in the scientific coordination of the congress.
Over five days, participants shared the latest advances in liver vascular biology, inflammation, immunity and fibrosis, as well as new findings on liver diseases. The programme included talks by international experts, oral presentations and poster sessions, encouraging scientific discussion and new collaborations.
Within the congress, the DIAMET group from IRB CatSud had an active role with several scientific contributions. Sonia Fernández-Veledo chaired a session on stellate cell biology and fibrosis. Predoctoral researcher Laura Salmerón gave an oral presentation about how certain liver mechanisms influence immune response. Anna Marsal also presented a poster on how these mechanisms affect liver cell function and their response to nutrients.
One of the most important moments of the meeting was the celebration of the 50th anniversary of the International Society for Hepatic Sinusoidal Research (ISHSR), which reviewed 50 years of progress in this field. Key initiatives for the future were also presented, including an international agreement on the use of new experimental models in liver research.
International visibility and local impact
Beyond its scientific importance, the congress helped promote Tarragona as a city able to host large international events, combining excellent research with culture, heritage and gastronomy. The social programme included cultural activities and visits so participants could explore the region.
At the same time, the organisers promoted outreach activities through workshops in local schools, bringing biomedical research closer to students and encouraging interest in science.
This edition also created new collaborations, strengthening the role of Tarragona and IRB CatSud in international liver research.
Scientific outreach in local schools
As part of the activities before the congress, researchers from IRB CatSud, CIBER and CSIC, together with members of the Scientific Committee, organised outreach actions to bring biomedical research and liver science closer to the local community.
They held four workshops for secondary school students (3rd year ESO) from Vedruna Tarragona and La Salle Torreforta. These sessions explained the liver, health and research in a simple and interactive way.
This initiative helped increase students’ interest in science and highlighted the importance of research in understanding and treating liver diseases, while strengthening the connection between scientists and the local community. The workshops were led by researchers involved in the congress, including Jordi Gracia-Sancho, Anna Marsal, Anabel Fernández-Iglesias and Anna Moles.
The congress was supported by several institutions, including Tarragona City Council, Tarragona Provincial Council, the Spanish Ministry of Science, Innovation and Universities, and the Government of Catalonia.
After Tarragona, the next edition of the Liver Sinusoid Meeting will take place in Tokyo in October 2028.
Metabolic fatty liver disease is a common condition where fat builds up in the liver and affects the body’s metabolism. It is known that men and women experience this disease differently, but the reasons are still not fully understood.
A study from the Biomedical Research Institute CatSud (IRB CatSud, formerly IISPV), published in the journal Biology of Sex Differences, shows that the disease develops in different ways depending on sex.
To study this, researchers from the DIAMET group at IRB CatSud used an experimental model with mice that reproduces the early stages of the disease. This model helps to understand what happens before serious liver damage appears.
The results show that females have more severe liver changes than males at early stages, even though they are usually thought to be better protected in the long term. Females also showed signs of a weaker intestinal barrier, which suggests higher stress in the body.
In contrast, males lost weight, had better blood sugar control, and showed fewer liver problems, meaning they adapted better to the diet. These differences were also linked to changes in brain areas that control appetite, energy use, and inflammation.
Researchers also found that, over time, these results may change, with males becoming more affected in later stages of the disease.
Overall, the study shows that sex differences appear very early and follow different paths. Understanding these patterns can help develop better and more personalised treatments for both men and women.
The results also highlight the importance of including both sexes in biomedical research to improve prevention and treatment of this increasingly common disease.
Reference
Repollés-de-Dalmau, M., Marsal-Beltran, A., Núñez-Roa, C., Vendrell, J., Ceperuelo-Mallafré, V., & Fernández-Veledo, S. (2026). Sex-specific dynamics of MASLD reveal early hepatic and extrahepatic metabolic deterioration in females despite long-term protection. Biology of sex differences, 17(1), 92. https://doi.org/10.1186/s13293-026-00876-y
A study led by the Diabetes and Associated Metabolic Diseases (DIAMET) group at the Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud, formerly IISPV) shows that liver fibrosis and type 2 diabetes significantly modify the hormonal response after eating in people with fatty liver associated with metabolic dysfunction (MASLD). The research, published in the Journal of Physiology and Biochemistry, examines how both conditions affect the secretion of essential hormones for glucose control—such as glucagon and the incretins (GLP‑1, GLP‑2 and GIP)—after a standardized meal.
The results show that liver fibrosis is the most important factor influencing the increase in GLP‑1 levels, both in fasting conditions and after the meal, regardless of whether the patient has diabetes. In addition, when liver fibrosis and type 2 diabetes occur together, hormonal changes become stronger, suggesting a synergistic effect between both conditions. Type 2 diabetes is also linked to the loss of the normal suppression of glucagon after eating, a key process to keep blood glucose within healthy ranges.
These findings reinforce the idea that a fibrotic liver is not a passive organ, but plays an active role in metabolic dysregulation. Fibrosis not only reflects past damage but also contributes to generating new hormonal alterations. Understanding these changes is essential to improve clinical assessment and move towards more personalised treatments for MASLD.
With the growing prevalence of MASLD and type 2 diabetes, understanding how these conditions interact at the hormonal level is crucial to improve early diagnosis and optimise treatments based on the incretin–glucagon axis. The study provides evidence that can help identify subgroups of patients who may benefit from more specific therapeutic approaches, with a direct impact on clinical practice.
Overall, the results confirm that liver fibrosis is a central determinant of GLP‑1 levels, and that the coexistence of type 2 diabetes further intensifies these hormonal alterations. This knowledge highlights the need to design therapeutic strategies adapted to the metabolic and liver profile of each patient, especially in a context where both diseases are becoming increasingly common.
The study involved researchers from the Universitat Rovira i Virgili (URV), the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) – Hospital Clínic Barcelona, the research networks of the Instituto de Salud Carlos III (ISCIII) — the Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and the Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) — as well as the Hospital Universitari Joan XXIII (Tarragona).
The Solidarity Walk ‘Let’s Take a Step Against Diabetes’ aims to raise awareness among the population about the importance of adopting healthy lifestyle habits and to support biomedical research carried out in the region. All the funds raised will go to the Diabetes and Associated Metabolic Diseases Research Group (DIAMET) at IISPV, which focuses on finding new knowledge and strategies to improve the prevention, diagnosis, and treatment of diabetes and other metabolic diseases.
“The Perafort Town Council reaffirms its commitment to health, solidarity, and medical research through this initiative—values we consider essential for the well-being of our citizens. The funds are allocated to the IISPV to support research and scientific progress in this field,” said the mayor of Perafort, Joan Martí Pla i Pla. The Perafort Town Council thanks all the individuals and organizations involved and invites everyone to join this solidarity cause. Taking a step against diabetes is taking a step for everyone’s health.
There are different types of diabetes, but the most common are type 1 and type 2. Type 1 diabetes affects about 0.2% of the population in Spain, and around 10% of diagnosed cases are in young people and children. Type 2 diabetes affects between 6% and 14% of the population. This percentage depends on the age group considered, but the older the person, the higher the incidence.
The director of the IISPV, Joan Vendrell, explains that “diabetes is not visible, but it can be controlled with information and a healthy lifestyle. In this sense, events like the walk are very valuable, as they help raise awareness about the disease and its impact, and also promote the work we do. Moreover, they are an opportunity for people to contribute to the development of the various research projects underway at the Institute.”
With a registration fee of €5, participants will receive a commemorative T-shirt, enjoy breakfast and drinks in Els Garidells, and take part in a raffle of products offered by the event’s sponsors after the walk. Registration is open until November 21st, 2025, through the following link: https://serveis.iispv.cat/events/desena-caminada-contra-la-diabetis
Scientists from around the world will gather to discuss the liver sinusoid, a specialized type of blood capillary found in the liver, and its role in ageing, regeneration, and disease
