Unitat de recerca en pediatria, nutrició i desenvolupament humà (URPNDH)

NUTRICIÓ I METABOLISME
OBJECTIUS

La Unitat de Recerca en Pediatria, Nutrició i Desenvolupament Humà (URPNDH) és un grup de recerca multidisciplinari que té com a objectiu realitzar una investigació de qualitat, col·laborant estretament amb altres grups d’investigació i també amb els professionals responsables de la pràctica clínica, i que ajudi a donar respostes als problemes de salut més comuns que actualment afecten a la població pediàtrica.

RESPONSABLES
  • Ricardo Closa Monasterolo

  • Joaquín Escribano Subias

  • PRESENTACIÓ
  • Línies
  • Membres del grup
  • Projectes
  • Transferència
  • Publicacions
  • Contactar

Les seves principals línies d’investigació s’emmarquen dins l’estudi de problemes de salut relacionats amb la nutrició, com la obesitat o la malaltia celíaca, i també sobre l’efecte de l’alimentació del lactant en la seva salut i desenvolupament posterior mitjançant la ‘programació metabòlica’. La URPNDH te també per objectiu desenvolupar, des d’un enfocament de ‘Medicina Basada en l’Evidència’, revisions crítiques i sistemàtiques de la literatura d’aspectes relacionats amb les seves línies d’investigació.

Línia: nutrició i metabolisme infantil

  • Programació metabòlica precoç
  • Obesitat infantil: estudi de factors de risc cardiovascular, síndrome meta-bòlic i estratègies d’intervenció
  • Nutrició aplicada

Investigador principal: Ricardo Closa i Joaquín Escribano

Línia: gastroenterologia i nutrició

  • Malaltia celíaca

Investigador principal: Gema Castillejo

Línia: funció pulmonar i infeccions a l’edat pediàtrica
Investigador principal: Ricardo Closa i Joaquín Escribano

Línia: medicina basada en l’evidència

  • Revisions sistemàtiques de la literatura
  • Avaluació de la composició corporal

Investigador principal: Verònica Luque

  • Títol: JRC – GNNS and neonatal care
    Entitat finançadora: Joint Research Center
    Anys: 01/01/2020 – 31/03/2020

  • Títol: EFECTO DE UN INTERVENCION MOTIVACIONAL SOBRE LA MICROBIOTA INTESTINAL Y LOS COMPONENTES DEL SINDROME METABOLICO EN UNA POBLACION OBESA PEDIATRICA: MICROBEKIDS.
    Referència: PI18/00226 IISPV
    Entitat finançadora: Instituto de Salud Carlos III
    Anys: 01/01/2019 – 31/12/2021

  • Títol: “Evaluation of nutritional suitability and tolerability of a human milk ligosaccharides (HMO) mix infant formula for term infant”
    Entitat finançadora: Jennewein Biotechnologie GmbH
    Anys: 01/01/2019 – 31/12/2020

  • Títol: Eficacia clínica y metabólica del abordaje motivacional coordinado entre atención primaria y especializada para el tratamiento de la obesidad infantil: ensayo clínico controlado y aleatorizado
    Referència: PI15/00970
    Entitat finançadora: Instituto de Salud Carlos III
    Anys: 01/01/2016 – 31/12/2019

  • Títol: Effects of milk protein intake in young children on early growth and later obesity risk: a multicentre randomized clinical trial (TOMI)
    Entitat finançadora: Nestec Ltd.
    Anys: 01/06/2015 – 31/12/2024

  • Title: Motivational Therapy for the Treatment of Childhood Obesity
    I-Depot number: 119460
    Authors: Feliu Rovira, A; Luque Moreno, V; Escribano Subías, J; Closa Monasterolo, R; Ferré Pallàs; Guillen Rey, N
    Institutions: IISPV, URV

  • Title: Motivational Approach to Treat Childhood Obesity (OBEMAT20) MAT
    I-Depot number: 119353
    Authors: Luque Moreno, V; Feliu Rovira, A; Guillen Rey, N; Gutiérrez Marin, D; Escribano Subías, J; Closa Monasterolo, R; Ferré Pallàs, N; Cabré Ambròs, J
    Institutions: IISPV, URV

  • Guies de pràctica clínica
    Investigador principal: JOAQUÍN ESCRIBANO”
    “Línia: COMPOSICIÓ CORPORAL

    Mental performance in 8-year-old children fed reduced protein content formula during the 1st year of life: safety analysis of a randomised clinical trial

    Escribano J, Luque V, Canals-Sans J, Ferré N, Koletzko B, Grote V, Weber M, Gruszfeld D, Szott K, Verduci E, Riva E, Brasselle G, Poncelet P,Closa-Monasterolo R; EU Childhood Obesity Project Group
    Br J Nutr
    DOI: 10.1017/S0007114515000768

    European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease

    Husby S, Koletzko S, Korponay-Szabó I, Kurppa K, Mearin ML, Ribes-Koninckx C, Shamir R, Troncone R, Auricchio R, Castillejo G, Christensen R, Dolinsek J, Gillett P, Hróbjartsson A, Koltai T, Maki M, Nielsen SM, Popp A, Størdal K, Werkstetter K, Wessels M.
    J Pediatr Gastroenterol Nutr
    DOI: 10.1097/MPG.0000000000002497

    Impact of infant protein supply and other early life factors on plasma metabolome at 5.5 and 8 years of age: a randomized trial

    Kirchberg FF, Hellmuth C, Totzauer M, Uhl O, Closa-Monasterolo R, Escribano J, Gruszfeld D, Gradowska K, Verduci E, Mariani B, Moretti M, Rousseaux D,Koletzko B; European Childhood Obesity Trial Study Group
    Int J Obes (Lond)
    DOI: 10.1038/s41366-019-0398-9

    Recommendations of the Spanish Society of Paediatric Cardiology and Congenital Heart Disease as regards the use of drugs in attention deficit hyperactivity disorder in children and adolescents with a known heart disease, as well as in the general paediatric population: Position statement by the Spanish Paediatric Association

    Pérez-Lescure Picarzo J, Centeno Malfaz F, Collell Hernández R, CrespoMarcos D, Fernández Soria T, Manso García B, Rojo Sombrero H, Sabaté Rotés A,Sarquella-Brugada G
    An Pediatr (Barc)
    DOI: 10.1016/j.anpedi.2019.09.002

    An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children

    Hellmuth C, Kirchberg FF, Brandt S, Moß A, Walter V, Rothenbacher D, BrennerH, Grote V, Gruszfeld D, Socha P, Closa-Monasterolo R, Escribano J, Luque V,Verduci E, Mariani B, Langhendries JP, Poncelet P, Heinrich J, Lehmann I, Standl M, Uhl O, Koletzko B, Thiering E, Wabitsch M
    Sci Rep
    DOI: 10.1038/s41598-019-41449-x

    Are all breast-fed infants equal? Clustering metabolomics data to identify predictive risk clusters for childhood obesity

    Kirchberg FF, Grote V, Gruszfeld D, Socha P, Closa-Monasterolo R, Escribano J, Verduci E, Mariani B, Langhendries JP, Poncelet P, Koletzko B, Hellmuth C;European Childhood Obesity Trial Study Group
    J Pediatr Gastroenterol Nutr
    DOI: 10.1097/MPG.0000000000002184

    Association of birth weight with type 2 diabetes and glycemic traits: A mendelian randomization study

    BIRTH-GENE (BIG) Study Working Group, Huang T, Wang T, Zheng Y, Ellervik C, Li X, Gao M, Fang Z, Chai JF, Ahluwalia TVS, Wang Y, Voortman T, Noordam R,Frazier-Wood A, Scholz M, Sonestedt E, Akiyama M, Dorajoo R, Zhou A, Kilpeläinen TO, Kleber ME, Crozier SR, Godfrey KM, Lemaitre R, Felix JF, Shi Y, Gupta P, KhorCC, Lehtimäki T, Wang CA, Tiesler CMT, Thiering E, Standl M, Rzehak P, Marouli E,He M, Lecoeur C, Corella D, Lai CQ, Moreno LA, Pitkänen N, Boreham CA, Zhang T,Saw SM, Ridker PM, Graff M, van Rooij FJA, Uitterlinden AG, Hofman A, van Heemst D, Rosendaal FR, de Mutsert R, Burkhardt R, Schulz CA, Ericson U, Kamatani Y,Yuan JM, Power C, Hansen T, Sørensen TIA, Tjønneland A, Overvad K, Delgado G,Cooper C, Djousse L, Rivadeneira F, Jameson K, Zhao W, Liu J, Lee NR, RaitakariO, Kähönen M, Viikari J, Grote V, Langhendries JP, Koletzko B, Escribano J,Verduci E, Dedoussis G, Yu C, Tham YC, Lim B, Lim SH, Froguel P, Balkau B, FinkNR, Vinding RK, Sevelsted A, Bisgaard H, Coltell O, Dallongeville J, Gottrand F, Pahkala K, Niinikoski H, Hyppönen E, Pedersen O, März W, Inskip H, Jaddoe VWV,Dennison E, Wong TY, Sabanayagam C, Tai ES, Mohlke KL, Mackey DA, Gruszfeld D,Deloukas P, Tucker KL, Fumeron F, Bønnelykke K, Rossing P, Estruch R, Ordovas JM,Arnett DK, Meirhaeghe A, Amouyel P, Cheng CY, Sim X, Teo YY, van Dam RM, Koh WP, Orho-Melander M, Loeffler M, Kubo M, Thiery J, Mook-Kanamori DO, Mozaffarian D,Psaty BM, Franco OH, Wu T, North KE, Davey Smith G, Chavarro JE, Chasman DI, QiL
    JAMA Netw Open
    DOI: 10.1001/jamanetworkopen.2019.10915

    Associations of age and body mass index with hydration and density of fat-free mass from 4 to 22 years

    Gutiérrez-Marín D, Luque V, Ferré N, Fewtrell MS, Williams JE, Wells JCK
    Eur J Clin Nutr
    DOI: 10.1038/s41430-019-0447-4

    Associations of sugar intake with anthropometrics in children from ages 2 until 8 years in the EU Childhood Obesity Project

    Aumueller N, Gruszfeld D, Gradowska K, Escribano J, Ferré N, Rousseaux D,Hoyos J, Verduci E, ReDionigi A, Koletzko B, Grote V
    Eur J Nutr
    DOI: 10.1007/s00394-019-02107-0

    Cardiopulmonary resuscitation in newborn infants with ultrasound in the delivery room.

    Rodriguez-Fanjul J, Perez-Baena L, Perez A.
    J Matern Fetal Neonatal Med.
    DOI: 10.1080/14767058.2019.1661379

    Chest ultrasound for diagnosis of transfusion-related acute lung injury.

    Rosich Del Cacho B, Sorribes Ortiz CA, Rodríguez-Fanjul J.
    Med Intensiva.
    DOI: 10.1016/j.medin.2019.07.002

    Commercial complementary food use amongst European infants and children: results from the EU Childhood Obesity Project

    Theurich MA, Zaragoza-Jordana M, Luque V, Gruszfeld D, Gradowska K, XhonneuxA, Riva E, Verduci E, Poncelet P, Damianidi L, Koletzko B, Grote V
    Eur J Nutr
    DOI: 10.1007/s00394-019-02023-3

    Correction to: Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R,Rousseaux D, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Int J Behav Nutr Phys Act
    DOI: 10.1186/s12966-019-0785-6

    Correction to: Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years.

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R, Rousseaux D, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Int J Behav Nutr Phys Act
    DOI: 10.1186/s12966-019-0785-6

    Cultural effects on neurodevelopmental testing in children from six European countries: an analysisof NUTRIMENTHE Global Database

    Pérez-García M, Luna JD, Torres-Espínola FJ, Martínez-Zaldívar C, Anjos T,Steenweg-de Graaff J, Weber M, Grote V, Gruszfeld D, Verduci E, Poncelet P,Escribano J, Tiemeier H, Koletzko B, Campoy C
    Br J Nutr
    DOI: 10.1017/S0007114517000824

    Does the fortified milk with high iron dose improve the neurodevelopment of healthy infants? Randomized controlled trial

    Iglesias Vázquez L, Canals J, Voltas N, Jardí C, Hernández C, Bedmar C,Escribano J, Aranda N, Jiménez R, Barroso JM, Ribot B, Arija V
    BMC Pediatr
    DOI: 10.1186/s12887-019-1679-0

    European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders

    Al-Toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, MulderCJ, Lundin KEA
    United EuropeanGastroenterol J
    DOI: 10.1177/2050640619844125

    Lung ultrasound in children: What does it give us?

    Bobillo-Perez S, Girona-Alarcon M, Rodriguez-Fanjul J, Jordan I, Balaguer
    Gargallo M.
    Paediatr Respir Rev.
    DOI: 10.1016/j.prrv.2019.09.006

    Lung ultrasound in the follow-up of primary ciliary dyskinesia.

    Guitart C, Del Rey Hurtado de Mendoza B, Camprubi Camprubi M, Rodriguez-Fanjul J.
    J Matern Fetal Neonatal Med.
    DOI: 10.1080/14767058.2019.1636027

    Lung Ultrasound to Assess the Etiology of Persistent Pulmonary Hypertension of the Newborn (LUPPHYN Study): A Pilot Study.

    Del Rey Hurtado de Mendoza B, Sánchez-de-Toledo J, Bobillo Perez S, Girona M, Balaguer Gargallo M, Rodríguez-Fanjul J.
    Neonatology
    DOI: 10.1159/000499047

    Neonatal Marfan Syndrome: A Rare, Severe, and Life-Threatening Genetic Disease.

    Solé-Ribalta A, Rodríguez-Fanjul X, Carretero-Bellon JM, Pascual-Sala C, Martorell-Sampol L, Bobillo-Pérez S, Morillo-Palomo AM.
    J Pediatr.
    DOI: 10.1016/j.jpeds.2019.03.033

    Nutritionduring pregnancy, lactation and early childhood and its implications for maternal and long-term child health: The Early Nutrition Project recommendations.

    Koletzko B, Godfrey KM, Poston L, Szajewska H, van Goudoever JB, de Waard M, Brands B, Grivell RM, Deussen AR, Dodd JM, Patro-Golab B, Zalewski BM; EarlyNutrition Project Systematic Review Group
    Ann Nutr Metab
    DOI: 10.1159/000496471

    Physical activity and sedentary behavior from 6 to 11 years

    Schwarzfischer P, Gruszfeld D, Stolarczyk A, Ferre N, Escribano J, RousseauxD, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Pediatrics
    DOI: 10.1542/peds.2018-0994

    Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten-free diet.

    Comino I, Segura V, Ortigosa L, Espín B, Castillejo G, Garrote JA, Sierra C, Millán A, Ribes-Koninckx C, Román E, Rodríguez-Herrera A, Díaz J, Silvester JA, Cebolla Á, Sousa C.
    Aliment Pharmacol Ther
    DOI: 10.1111/apt.15277

    Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus.

    Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J, Kurepa D, Feng X, Cattaross L, Zhang H, Hwang M, Yeh TF, Lipener Y, Lodha A, Wang JQ, Cao HY, Hu CB, Lyu GR, Qiu XR, Jia LQ, Wang XM, Ren XL, Guo JY, Gao YQ, Li JJ, Liu Y, Fu W, Wang Y, Lu ZL, Wang HW, Shang LL.
    J Vis Exp.
    DOI: 10.3791/58990

    Refractory Cardiogenic Shock due to Enterovirus Myocarditis: Experience at one Institution.

    Bobillo-Perez S, Sanchez-de-Toledo J, Matute SS, Balaguer M, Jordan I, Rodriguez-Fanjul J.
    Med Intensiva.
    DOI: 10.1016/j.medin.2019.03.006

    Should abdominal ultrasound be the first image choice test in necrotizing enterocolitis?

    Batista Muñoz A, Otero Vaccarello O, Rodriguez-Fanjul J
    Med Intensiva.
    DOI: 10.1016/j.medin.2019.09.014

    The Obemat2.0 Study: A clinical trial of a motivational intervention for childhood obesity treatment

    Luque V, Feliu A, Escribano J, Ferré N, Flores G, Monné R, Gutiérrez-MarínD, Guillen N, Muñoz-Hernando J, Zaragoza-Jordana M, Gispert-Llauradó M,Rubio-Torrents C, Núñez-Roig M, Alcázar M, Ferré R, Basora JM, Hsu P,Alegret-Basora C, Arasa F, Venables M, Singh P, Closa-Monasterolo R
    Nutrients
    DOI: 10.3390/nu11020419

    Ultrasound-guided recruitment maneuvers in pediatric acute chest syndrome due to sickle cell disease.

    Bobillo-Perez S, Rodriguez-Fanjul J, Girona-Alarcon M, Cambra FJ, Jordan I, Balaguer M.
    Med Intensiva.
    DOI: 10.1016/j.medin.2019.06.002

    Variation and interdependencies of human milk macronutrients, fatty acids, adiponectin, insulin, and IGF-II in the European Prevent CD Cohort

    Grunewald M, Hellmuth C, Kirchberg FF, Mearin ML, Auricchio R, Castillejo G,Korponay-Szabo IR, Polanco I, Roca M, Vriezinga SL, Werkstetter K, Koletzko B,Demmelmair H
    Nutrients
    DOI: 10.3390/nu11092034

    Longitudinal analysis of physical activity, sedentary behaviour and anthropometric measures from ages 6 to 11 years.

    Schwarzfischer P, Gruszfeld D, Socha P, Luque V, Closa-Monasterolo R, Rousseaux D, Moretti M, Mariani B, Verduci E, Koletzko B, Grote V
    Int J Behav Nutr Phys Act
    DOI: 10.1186/s12966-018-0756-3

Membres De L’equip

  • Responsable de grup

    • Ricardo Closa Monasterolo
    • Joaquín Escribano Subias
  • Investigador/a Post-doctoral

    • Ester Parada Ricart
    • Verònica Luque Moreno
    • Albert Feliu Rovira
    • Rosa Collell Hernández
    • M. Carmen Rubio Torrents
    • Marta Zaragoza Jordana
    • Mariona Gispert Llauradó
    • Natàlia Ferré Pallàs
    • Javier Rodríguez Fanjul
  • Doctorant

    • Gemma Castillejo de Villasante
    • Judit Muñoz Hernando
    • Mireia Alcázar López
    • Mercè Nuñez Roig
    • Neus Rius Gordillo
    • Susana Larrosa Capaces
    • Elisabet Camprubí Tubella
    • David Medina Santamaria
  • Assistencial

    • Adolfo Gómez Papi