{"id":75257,"date":"2023-03-27T15:59:37","date_gmt":"2023-03-27T14:59:37","guid":{"rendered":"https:\/\/www.iispv.cat\/?p=75257"},"modified":"2023-04-20T08:22:38","modified_gmt":"2023-04-20T07:22:38","slug":"discovered-a-new-mechanism-that-regulates-our-biological-clock-and-the-hormone-that-controls-appetite","status":"publish","type":"post","link":"https:\/\/www.iispv.cat\/en\/discovered-a-new-mechanism-that-regulates-our-biological-clock-and-the-hormone-that-controls-appetite\/","title":{"rendered":"Discovered a new mechanism that regulates our biological clock and the hormone that controls appetite"},"content":{"rendered":"\n<ul class=\"wp-block-list\"><li><strong>It is the result of a study by the DIAMET research group of the IISPV, which focuses on the role of the succinate metabolite and its relationship with leptin, a hormone that regulates satiety<\/strong><\/li><li><strong>In the case of obese people, this satiety mechanism is altered since, despite having high blood leptin levels, their body does not respond to its signal<\/strong><\/li><\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.iispv.cat\/wp-content\/uploads\/2023\/03\/Foto-1024x746.jpg\" alt=\"D\u2019esquerra a dreta: Part de l\u2019equip d\u2019investigadors i investigadores del Grup de Recerca DIAMET de l\u2019IISPV que ha participat en l\u2019estudi: L\u00eddia Ced\u00f3 Gin\u00e9, Teresa Villanueva Carmona, Sonia Fern\u00e1ndez-Veledo i Joan Vendrell. \" class=\"wp-image-75251\" width=\"739\" height=\"537\" srcset=\"https:\/\/www.iispv.cat\/wp-content\/uploads\/2023\/03\/Foto-1024x746.jpg 1024w, https:\/\/www.iispv.cat\/wp-content\/uploads\/2023\/03\/Foto-300x219.jpg 300w, https:\/\/www.iispv.cat\/wp-content\/uploads\/2023\/03\/Foto.jpg 1201w\" sizes=\"auto, (max-width: 739px) 100vw, 739px\" \/><figcaption><strong>From left to right<\/strong>: Part of the team of researchers from the DIAMET Research Group of the IISPV that has participated in the study: L\u00eddia Ced\u00f3 Gin\u00e9, Teresa Villanueva Carmona, Sonia Fern\u00e1ndez-Veledo and Joan Vendrell.<\/figcaption><\/figure><\/div>\n\n\n<p>A study published in the prestigious Cell Metabolism journal and led by the Diabetes and<br>Associated Metabolic Diseases (DIAMET) research group of the Pere Virgili Health Research<br>Institute (IIPSV) and linked to the Joan XXIII University Hospital of Tarragona, has made it<br>possible to discover the mechanism through which adipocytes (the cells that primarily compose<br>adipose tissue) produce leptin, one of the main hormones that regulates appetite. It has also<br>been identified that this new mechanism regulates the biological clock of fat cells. In fact, today<br>it is known that adipocytes have their own internal clock (independent of external factors such<br>as light), which is essential for adipose tissue to perform its functions correctly.<\/p>\n\n\n\n<p>The historical discovery of leptin as a hormone secreted by adipocytes in the 1990s led to a<br>paradigm shift, as it showed that the body fat must be considered an active endocrine organ<br>that regulates satiety and body weight. From that moment, even though numerous scientific<br>papers have studied how leptin acts in the central nervous system (it inhibits the intake by<br>producing the feeling of satiety) and why in obese people this mechanism does not work<br>correctly, no significant advances had been made regarding the production process of this<br>hormone in adipose tissue.<\/p>\n\n\n\n<p>This research, which has received more than one million euros from the Fundaci\u00f3n \u201cla Caixa\u201d<br>and from the Agencia Estatal de Investigaci\u00f3n (Ministerio de Ciencia e Innovaci\u00f3n), represents a very significant milestone not only from the physiological point of view (since it helps to improve<br>understanding of the biological processes that control body weight), but also for addressing<br>metabolic diseases such as obesity.<\/p>\n\n\n\n<p>In the words of Sonia Fern\u00e1ndez-Veledo, researcher at the IIPSV and head of DIAMET: &#8220;If<br>everything works correctly, when we eat, the levels of leptin in the blood increase. This hormone<br>is responsible for sending the satiety signal to our brain. Obese people produce more leptin than<br>thin people, but in turn, a phenomenon known as leptin resistance develops, which means that<br>the body does not respond to this hormone. Therefore, people with obesity have the mechanism<br>of satiety altered. Our study not only demonstrates the mechanism by which adipocytes produce<br>leptin, but also why obese people\u2019s fat does so excessively.&#8221;<br>According to the World Health Organization (WHO), more than one billion people worldwide are<br>obese, data that continues an upward trend. WHO also warns that obesity is directly associated<br>with type 2 diabetes, cardiovascular diseases and those related to mental health, hypertension,<br>stroke and various forms of cancer.<\/p>\n\n\n\n<p><strong>Succinate, key in this process<\/strong><\/p>\n\n\n\n<p>Succinate, an energetic metabolite that can also act as a hormone through its SUCNR1 receptor,<br>plays a very important role in all these processes. The DIAMET group is an international<br>benchmark in the study of this metabolite in the context of inflammatory and metabolic diseases<br>(such as obesity and diabetes). For many years, a mainly inflammatory role has been attributed<br>to this metabolite, in addition to being identified as a biomarker of metabolic dysfunction in<br>diseases such as obesity and diabetes (in this type of patients its levels are chronically elevated).<br>However, in recent years, the DIAMET group has shown that this is a complex system, since<br>succinate levels also increase (although transiently) in some physiological situations, such as<br>when we eat food. <\/p>\n\n\n\n<p>In the words of Sonia Fern\u00e1ndez-Veledo: &#8220;It is in this context where we believe that succinate &#8211;<br>through its receptor SUCNR1- naturally regulates energy homeostasis, that is, the internal<br>functions of our organism that control the balance between energy intake and its expenditure.<br>In this study we demonstrated that one of the mechanisms is through the production of leptin<br>and, therefore, through the feeling of satiety, but we anticipate that it will have other<br>physiological functions acting on other tissues. In addition, we demonstrate that succinate<br>would determine leptin oscillations throughout the day by controlling the biological clock of adipocytes. In obese people, this mechanism is hyperactivated, which would partly explain the<br>elevated leptin levels.&#8221;<\/p>\n\n\n\n<p>This scientific advance represents a turning point in the treatment of obesity and opens the<br>doors to future studies aimed at investigating not only other metabolic functions of succinate,<br>but also at exploring therapies that allow restoring this mechanism, thus achieving that its levels,<br>as well like those of the hormone leptin, can be stabilized and it can recover its role in regulating<br>the feeling of satiety.<\/p>\n\n\n\n<p>The study has received funding from the CaixaResearch Health Research Call (Fundaci\u00f3n \u201dla<br>Caixa\u201d) and from the Agencia Estatal de Investigaci\u00f3n (Ministerio de Ciencia e Innovaci\u00f3n). It has<br>been possible thanks to the joint effort and commitment of several institutions: the Centro de<br>Investigaci\u00f3n Biom\u00e9dica en Red &#8211; Diabetes y Enfermedades Metab\u00f3licas (CIBERDEM), the CIBER<br>de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), the Centres de Recerca de Catalunya<br>(CERCA), the Rovira i Virgili University, Joan XXIII University Hospital of Tarragona, the Instituto<br>de Investigaciones Biom\u00e9dicas Alberto Sols, the Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge<br>(IDIBELL), the Institut d\u2019Investigacions Biom\u00e8diques (IBI) Sant Pau, the Universitat Aut\u00f2noma de<br>Barcelona (UAB), the Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona (IDIBGI), the Universitat de<br>Girona and the Universitat de Barcelona.<\/p>\n\n\n\n<p><strong>Bibliographic reference<\/strong>: SUCNR1 signaling in adipocytes controls energy metabolism by<br>modulating circadian clock and leptin expression. Villanueva-Carmona T, Ced\u00f3 l, Madeira A,<br>Ceperuelo-Mallafr\u00e9 V, Rodr\u00edguez-Pe\u00f1a M-M, N\u00fa\u00f1ez-Roa C, Maym\u00f3-Masip E, Repoll\u00e9s-De-<br>Dalmau E, Badia J, Keiran N, Mirasierra M, Pimenta-Lopes C, Sabadell-Basallote J, Bosch R,<br>Caubet L , Carles Escol\u00e0-Gil J, Fernandez-Real JM, Vilarrasa N, Ventura F, Vallejo M, Vendrell J,<br>Fern\u00e1ndez-Veledo S. 2023, Cell Metabolism 35, 1\u201319 April 4, 2023.<br>https:\/\/doi.org\/10.1016\/j.cmet.2023.03.004<\/p>\n\n\n\n<p>Nature Reviews Endocrinology has published a \u201cResearch Highlight\u201d on this article:<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41574-023-00838-z\">https:\/\/www.nature.com\/articles\/s41574-023-00838-z<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is the result of a study by the DIAMET research group of the IISPV, which focuses on the role of the succinate metabolite and its relationship with leptin, a hormone that regulates satiety In the case of obese people, this satiety mechanism is altered since, despite having high blood leptin levels, their body does [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":75251,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1477,1026,1831],"tags":[],"class_list":["post-75257","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovacio-en","category-noticies-iispv-en","category-press-releases"],"_links":{"self":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts\/75257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/comments?post=75257"}],"version-history":[{"count":3,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts\/75257\/revisions"}],"predecessor-version":[{"id":80111,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts\/75257\/revisions\/80111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/media\/75251"}],"wp:attachment":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/media?parent=75257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/categories?post=75257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/tags?post=75257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}