Metabolic fatty liver disease is a common condition where fat builds up in the liver and affects the body\u2019s metabolism. It is known that men and women experience this disease differently, but the reasons are still not fully understood.<\/p>\n
A study from the Biomedical Research Institute CatSud (IRB CatSud, formerly IISPV), published in the journal Biology of Sex Differences<\/em>, shows that the disease develops in different ways depending on sex.<\/p>\n To study this, researchers from the DIAMET group at IRB CatSud used an experimental model with mice that reproduces the early stages of the disease. This model helps to understand what happens before serious liver damage appears.<\/p>\n The results show that females have more severe liver changes than males at early stages, even though they are usually thought to be better protected in the long term. Females also showed signs of a weaker intestinal barrier, which suggests higher stress in the body.<\/p>\n In contrast, males lost weight, had better blood sugar control, and showed fewer liver problems, meaning they adapted better to the diet. These differences were also linked to changes in brain areas that control appetite, energy use, and inflammation.<\/p>\n Researchers also found that, over time, these results may change, with males becoming more affected in later stages of the disease.<\/p>\n Overall, the study shows that sex differences appear very early and follow different paths. Understanding these patterns can help develop better and more personalised treatments for both men and women.<\/p>\n The results also highlight the importance of including both sexes in biomedical research to improve prevention and treatment of this increasingly common disease.<\/p>\n Reference\u00a0<\/strong><\/p>\n Repoll\u00e9s-de-Dalmau, M., Marsal-Beltran, A., N\u00fa\u00f1ez-Roa, C., Vendrell, J., Ceperuelo-Mallafr\u00e9, V., & Fern\u00e1ndez-Veledo, S. (2026). Sex-specific dynamics of MASLD reveal early hepatic and extrahepatic metabolic deterioration in females despite long-term protection<\/em>.\u00a0Biology of sex differences,\u00a017<\/em>(1), 92. https:\/\/doi.org\/10.1186\/s13293-026-00876-y<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":" Metabolic fatty liver disease is a common condition where fat builds up in the liver and affects the body\u2019s metabolism. It is known that men and women experience this disease differently, but the reasons are still not fully understood. A study from the Biomedical Research Institute CatSud (IRB CatSud, formerly IISPV), published in the journal […]<\/p>\n","protected":false},"author":36,"featured_media":114147,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1883,1026,1478,1479,2092],"tags":[2971,2359,2804,2970,2969],"class_list":["post-114154","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualitat-en","category-noticies-iispv-en","category-publicacions-en","category-recerca-en","category-temes-de-salut-en","tag-common-liver-disorder","tag-diamet-en","tag-irb-catsud-en","tag-metabolic-fatty-liver","tag-sex"],"_links":{"self":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts\/114154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/comments?post=114154"}],"version-history":[{"count":0,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/posts\/114154\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/media\/114147"}],"wp:attachment":[{"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/media?parent=114154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/categories?post=114154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iispv.cat\/en\/wp-json\/wp\/v2\/tags?post=114154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}