Obesity and Metabolic Surgery


A surgery research group is a group that currently combines clinical research and experimental research, interacting at the same time with other groups and disciplines. Her main line of research is bariatric and metabolic surgery. The main objective of the research is to analyze the weight, intake, and hormonal response after this type of surgery. The training of our team in this field is ongoing, while we are part of the statewide network of trainers for young residents and surgeons. We also participate as teachers in the master’s degree in bariatric surgery. Various competitive projects have supported our research as well as publications in high-impact scientific journals.

  • Dr. Daniel del Castillo Déjardin

  • Research lines
  • Group members
  • Publications
  • Projects
  • Contact
  • Obesity surgery and clinical metabolism.
  • Obesity surgery and experimental metabolism (experimental animals).
  • Surgical pathophysiology of gastrointestinal hormones.
  • Nonalcoholic hepatic steatosis (NAFLD) and bariatric surgery.
  • Changes in the intestinal microbiota and bariatric surgery.
  • Pathophysiology of intestinal absorption and bariatric surgery.
  • Abdominal wall pathology and bariatric surgery.
  • Nutritional assessment and bariatric surgery.


    Circulating microbiota-derived metabolites: a "liquid biopsy?

    Aragonès G, Colom-Pellicer M, Aguilar C, Guiu-Jurado E, Martínez S, Sabench F, Antonio Porras J, Riesco D, Del Castillo D, Richart C, Auguet T.
    Int J Obes (Lond). 2020 Apr;44(4):875-885.

    DOI: 10.1038/s41366-019-0430-0

    Insights into the treatment of postsleeve gastrectomy leak: analysis of the results of 105 cases on a national register

    Balagué C, Ruiz de Adana JC, Ibarzabal A, Del Castillo D, Puche JJ, Vilallonga R.
    Surg Obes Relat Dis. 2021 Jan;17(1):36-43.

    DOI: 10.1016/j.soard.2020.09.001

    Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD

    Binetti J, Bertran L, Riesco D, Aguilar C, Martínez S, Sabench F, Porras JA, Camaron J, Castillo DD, Richart C, Auguet T.
    Life (Basel). 2020 Oct 16;10(10):245.

    DOI: 10.3390/life10100245

    Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver

    Auguet T, Bertran L, Binetti J, Aguilar C, Martínez S, Guiu-Jurado E, Sabench F, Adalid L, Porras JA, Riesco D, Del Castillo D, Richart C.
    Obesity (Silver Spring). 2020 Aug;28(8):1487-1493.

    DOI: 10.1002/oby.22873

    Quantitative and Topographic Analysis by Immunohistochemical Expression of Ghrelin Gastric Cells in Patients with Morbid Obesity

    Parada D D, Peña G KB, Vives M, Molina A, Mayayo E, Riu F, Sabench F, Del Castillo D.
    Diabetes Metab Syndr Obes. 2020 Aug 18;13:2855-2864.

    DOI: 10.2147/DMSO.S260483

    Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis

    Auguet T, Bertran L, Binetti J, Aguilar C, Martínez S, Sabench F, Lopez-Dupla JM, Porras JA, Riesco D, Del Castillo D, Richart C.
    Int J Mol Sci. 2020 Jun 11;21(11):4189.

    DOI: 10.3390/ijms21114189

    Analysis of mid-term weight loss after Roux-en-Y gastric bypass and sleeve gastrectomy: Proposed percentile charts for total weight loss percentages to be used in daily clinical practice

    Sabench Pereferrer F, Molina López A, Acín Gándara D, Arroyo Martín JJ, Baltar Boileve J, Barranco Moreno A, Cassinello Fernández N, Del Castillo Déjardin D, Fernández Alsina E, Ferrer-Márquez M, Mans Muntwyler E, Martín García-Almenta E, García Ruiz de Gordejuela A.
    Cir Esp (Engl Ed). 2020 Feb;98(2):72-78. English, Spanish.

    DOI: 10.1016/j.ciresp.2019.09.008

    Intestinal obstruction caused by Anisakis

    Bartra Balcells È, Domenech Calvet J, Del Castillo Déjardin D.
    2020 Nov 27 [Epub ahead of print].Rev Esp Enferm Dig.

    DOI: 10.17235/reed.2020.7409/2020

  • Title: PI18/00081 Cambios en las isoformas de grelina y la microbiota en relación a la gastrectomía vertical y a la presencia de helicobácter pylory: análisis metabolómico, metagenómico e inmunohistoquímico.

    Funding entity: Instituto Carlos III

    Duration: 2019 – 2021

    Principal Investigator: Daniel Del Castillo Déjardin

  • Title: ¿Modifica la cirugía bariátrica la enfermedad del hígado graso no alcohólico (EHGNA) a través de los cambios inducidos en la microbiota?

    Funding entity: Sociedad Española de Cirugía de la Obesidad Mórbida y de las enfermedades metabólicas (S.E.C.O)

    Duration: 2017 – 2020

    Principal Investigator: Daniel Del Castillo Déjardin

Team Members

  • Group manager

    • Dr. Daniel del Castillo Déjardin
  • Senior researcher

    • Fàtima Sabench Pereferrer
  • Post-doctoral Researcher

    • Margarida Vives Espelta
    • Alicia Molina López
  • Welfare

    • Esther Raga Carceller
    • Joan Domènech Calvet
    • Antonio Sánchez Marín
  • Inv. Predoctoral

    • Amada Culebradas Barrera
    • Marta París Sans