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Synuclein Therapeutic Acceleration Program (SynTAP 2013)


The Michael J. Fox Foundation for Parkinson’s Research (MJFF) seeks to fund mid- to late-stage development of therapeutics targeting alpha-synuclein consisting of preclinical efficacy, target engagement, pharmacokinetics/pharmacodynamic evaluation, and/or safety & toxicology studies. These studies should be designed to obtain data required for IND submission and future clinical testing of the therapeutic. Applicants may submit a proposal for consideration of up to two-years, and a maximum of $1M award.


MJFF has made significant investments in research to understand alpha-synuclein and to translate it into therapeutic strategies for advancing a cure for Parkinson’s disease. Through the SynTAP 2013 program, MJFF seeks to aggressively move therapeutic compounds and biologics targeting alpha-synuclein into clinical testing. MJFF seeks proposals for obtaining additional preclinical efficacy data, confirmation of target engagement, evaluation of pharmacokinetics/pharmacodynamics (PK/PD), dose-formulation, safety pharmacology and toxicology studies, which would provide supporting data to enable first-in-human (IND-enabling) studies.


FUNDING AVAILABLE: MJFF intends to fund multiple proposals as part of this initiative. Applicants may request up to two years and a maximum of $1,000,000 in total costs, inclusive of both direct and indirect costs. No more than 25% (Academic institutions) or 10% (for-profit organizations) of the direct costs may go to indirect costs. For details on MJFF’s indirect cost policy, please see the program instructions, Administrative Guidelines and our FAQ.

ELIGIBILITY REQUIREMENTS Applications may be submitted by:

  • U.S. and non-U.S. biotechnology/pharmaceutical companies or other for-profit entities, either publicly or privately held,
  • U.S. and non-U.S. entities, public and private non-profit entities, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government.

Post-doctoral fellows are NOT eligible to apply as Principal Investigators to this program.


Termini oficial

Informational Conference Call*: March 13, 2013, 12:00 pm (EST)
Pre-Proposals Due: April 3, 2013
Full Proposal Invitations: April 24, 2013
Full Proposals Due: June 12, 2013
Anticipated Award Announcement: September 2013
Anticipated Funding: October 2013

*MJFF will hold a 45-minute conference call at the time listed above to clarify and explain the goals of this funding initiative and answer applicant questions. To participate in the call and receive call-in details, please RSVP via email to conferencecalls@michaeljfox.org.

Termini IISPV

Cal comunicar abans del 4 de març de 2013 que es vol participar a la convocatòria, enviant un e-mail a europa@iispv.cat . Termini: 25 de març de 2013

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