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Birth, life and death of dopaminergic neurons: from developmental studies to Parkinson’s disease and in vitro disease modelling of psychiatric disorders

  • Dates and times: 24 de març de 2015 - Hora: 13.30h
  • Location: Institut d'Investigació Sanitària Pere Virgili (IISPV), Edifici d'R+D+I en Nutrició i Salut, Sala Polivalent, planta baixa; Avda. de la Universitat, 1 Reus

Purpose

Dopamine neurons play a central role in the modulation of several brain functions, and they are associated with major neurological and psychiatric disorders, such as Parkinson’s disease and schizophrenia. The development of regenerative strategies for the treatment of Parkinson’s disease critically depends on our capacity to identify novel genetic factors implicated in the development and survival of dopaminergic neurons. Human pluripotent cells offer a novel source for the in vitro generation of dopaminergic neurons for cell replacement therapy for the treatment of Parkinson’s disease, but they also offer an in vitro system for disease modelling at the cellular and network levels of dopamine related psychiatric disorders. Moreover, as many patients suffering of major psychiatric disorders present sleep disturbances, we will also discuss about retinal dopaminergic neurons, which contribute to the synchronization of the external environment with the circadian clock that controls sleep in our bodies.

El Dr. J. Carlos Villaescusa, Laboratory of Molecular Neurobiology, Department of Medical Biochemistry & Biophysics - Karolinska Institute - Stockholm (Sweden).

Organizes

Cicle de Seminaris 2014/2015 IISPV

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IISPV

IISPVInstitut d'Investigació Sanitària Pere Virgili (IISPV)

Work Center for R&D&I in Nutrition and Health
Avda. de la Universitat, 1 - Second floor
E-43204 Reus (Tarragona)

Tel. Work+34 977 75 93 94 http://www.iispv.cathttp://www.iispv.cat

Generalitat de Catalunya

Universitat Rovira i Virgili (URV)

ICS - Institut Català de la Salut

Hospital Universitari Sant Joan de Reus

Centre de Recerca de Catalunya

Spain Excellence University - Universitat Rovira i Virgili, Excellence Research Spain, Excellence Postgraduate Spain

HR Excellence in Research

Institut Pere Mata, Hospital Psiquiàtric Universitari

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